Ganodermycin, a novel inhibitor of cxcl10 expression from ganoderma applanatum
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Mathias Jung
- Johannes Liermann
- Till Opatz
- Gerhard Erkel
- Sammlungen
- metadata
- ISSN
- 0021-8820
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Journal of antibiotics
- Schlüsselwörter
- 540 Chemie
- 540 Chemistry and allied sciences
- Sprache
- eng
- Paginierung
- Seiten: 683 - 686
- Datum der Veröffentlichung
- 2011
- Herausgeber
- Nature Publ. Group
- Herausgeber URL
- http://dx.doi.org/10.1038/ja.2011.64
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Ganodermycin, a novel inhibitor of cxcl10 expression from ganoderma applanatum
- Ausgabe der Zeitschrift
- 64
Datenquelle: METADATA.UB
- Andere Metadatenquellen:
-
- Autoren
- Mathias Jung
- Johannes C Liermann
- Till Opatz
- Gerhard Erkel
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000296586400006&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1038/ja.2011.64
- Externe Identifier
- Clarivate Analytics Document Solution ID: 842HF
- PubMed Identifier: 21792205
- ISSN
- 0021-8820
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- JOURNAL OF ANTIBIOTICS
- Schlüsselwörter
- CXCL10
- Ganoderma
- inhibitor
- new metabolite
- Paginierung
- 683 - 686
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Titel
- Ganodermycin, a novel inhibitor of CXCL10 expression from <i>Ganoderma applanatum</i>
- Sub types
- Article
- Ausgabe der Zeitschrift
- 64
Datenquelle: Web of Science (Lite)
- Autoren
- Mathias Jung
- Johannes C Liermann
- Till Opatz
- Gerhard Erkel
- DOI
- 10.1038/ja.2011.64
- eISSN
- 1881-1469
- ISSN
- 0021-8820
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- The Journal of Antibiotics
- Sprache
- en
- Online publication date
- 2011
- Paginierung
- 683 - 686
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/ja.2011.64
- Datum der Datenerfassung
- 2023
- Titel
- Ganodermycin, a novel inhibitor of CXCL10 expression from Ganoderma applanatum
- Ausgabe der Zeitschrift
- 64
Datenquelle: Crossref
- Abstract
- CXCL10 (inducible protein-10) is a highly inducible chemoattractant, which contributes to the recruitment of inflammatory cells, such as macrophages and T-lymphocytes, and thereby has important roles in chronic inflammatory conditions. In a search for new inhibitors of CXCL10 expression in MonoMac6 cells, a novel compound, designated as Ganodermycin, was isolated from fermentations of the basidiomycete Ganoderma applanatum. The structure was determined by a combination of spectroscopic techniques. Ganodermycin inhibited the lipopolysaccharide (LPS)/interferon (IFN)-γ-induced CXCL10 promoter activity in transiently transfected MonoMac6 cells in a dose-dependent manner with IC(50) values of 15-20 μg ml(-1) (53-71 μM). Ganodermycin also reduced LPS/IFN-γ-induced CXCL10 protein synthesis and excretion.
- Addresses
- Institute of Biotechnology and Drug Research (IBWF), Kaiserslautern, Germany.
- Autoren
- Mathias Jung
- Johannes C Liermann
- Till Opatz
- Gerhard Erkel
- DOI
- 10.1038/ja.2011.64
- eISSN
- 1881-1469
- Externe Identifier
- PubMed Identifier: 21792205
- Open access
- false
- ISSN
- 0021-8820
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- The Journal of antibiotics
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2011
- Paginierung
- 683 - 686
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Datum der Datenerfassung
- 2011
- Titel
- Ganodermycin, a novel inhibitor of CXCL10 expression from Ganoderma applanatum.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 64
Datenquelle: Europe PubMed Central
- Abstract
- CXCL10 (inducible protein-10) is a highly inducible chemoattractant, which contributes to the recruitment of inflammatory cells, such as macrophages and T-lymphocytes, and thereby has important roles in chronic inflammatory conditions. In a search for new inhibitors of CXCL10 expression in MonoMac6 cells, a novel compound, designated as Ganodermycin, was isolated from fermentations of the basidiomycete Ganoderma applanatum. The structure was determined by a combination of spectroscopic techniques. Ganodermycin inhibited the lipopolysaccharide (LPS)/interferon (IFN)-γ-induced CXCL10 promoter activity in transiently transfected MonoMac6 cells in a dose-dependent manner with IC(50) values of 15-20 μg ml(-1) (53-71 μM). Ganodermycin also reduced LPS/IFN-γ-induced CXCL10 protein synthesis and excretion.
- Autoren
- Mathias Jung
- Johannes C Liermann
- Till Opatz
- Gerhard Erkel
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/21792205
- DOI
- 10.1038/ja.2011.64
- eISSN
- 1881-1469
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- J Antibiot (Tokyo)
- Sprache
- eng
- Country
- England
- Paginierung
- 683 - 686
- PII
- ja201164
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Titel
- Ganodermycin, a novel inhibitor of CXCL10 expression from Ganoderma applanatum.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 64
Datenquelle: PubMed
- Beziehungen:
- Eigentum von