3 '-demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory Diaryl ethers from a steganospora species

Autoren

Dominik Schreiber
Mathias Jung
Louis P Sandjo
Johannes C Liermann
Till Opatz
Gerhard Erkel

Autoren-URL

https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000309519600006&DestLinkType=FullRecord&DestApp=WOS_CPL

DOI

10.1038/ja.2012.46

eISSN

1881-1469

Externe Identifier

Clarivate Analytics Document Solution ID: 016LJ
PubMed Identifier: 22692347

ISSN

0021-8820

Ausgabe der Veröffentlichung

9

Zeitschrift

JOURNAL OF ANTIBIOTICS

Schlüsselwörter

CXCL10
3 '-demethyldihydromaldoxin
inhibitor

Paginierung

473 - 477

Datum der Veröffentlichung

2012

Status

Published

Titel

3′-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a <i>Steganospora</i> species

Sub types

Article

Ausgabe der Zeitschrift

65

Datenquelle: Web of Science (Lite)

Autoren

Dominik Schreiber
Mathias Jung
Louis P Sandjo
Johannes C Liermann
Till Opatz
Gerhard Erkel

DOI

10.1038/ja.2012.46

eISSN

1881-1469

ISSN

0021-8820

Ausgabe der Veröffentlichung

9

Zeitschrift

The Journal of Antibiotics

Sprache

en

Online publication date

2012

Paginierung

473 - 477

Datum der Veröffentlichung

2012

Status

Published

Herausgeber

Springer Science and Business Media LLC

Herausgeber URL

http://dx.doi.org/10.1038/ja.2012.46

Datum der Datenerfassung

2023

Titel

3′-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a Steganospora species

Ausgabe der Zeitschrift

65

Datenquelle: Crossref

Abstract

CXCL10 (IP-10) is a highly inducible chemoattractant, which contributes to the recruitment of inflammatory cells such as macrophages and T-lymphocytes and thereby has important roles in chronic inflammatory conditions. In a search for new inhibitors of CXCL10 expression in MonoMac6 (MM6) cells, the new diaryl ether 3'-demethyldihydromaldoxin (1) along with the known compound dihydromaldoxin (2), were isolated from fermentations of a Steganospora species. The structures of the compounds were elucidated by a combination of one- and two-dimensional NMR spectroscopy and mass spectrometry. Compounds (1) and (2) inhibited lipopolysaccharide (LPS)/interferon-γ (IFN-γ)-induced CXCL10 promoter activity in transiently transfected MM6 cells in a dose-dependent manner with IC(50) values of 39-41 μM and also reduced LPS/IFN-γ-induced CXCL10 protein synthesis and excretion.

Addresses

Department of Molecular Biotechnology and Systems Biology, University of Kaiserslautern, Kaiserslautern, Germany.

Autoren

Dominik Schreiber
Mathias Jung
Louis P Sandjo
Johannes C Liermann
Till Opatz
Gerhard Erkel

DOI

10.1038/ja.2012.46

eISSN

1881-1469

Externe Identifier

PubMed Identifier: 22692347

Open access

false

ISSN

0021-8820

Ausgabe der Veröffentlichung

9

Zeitschrift

The Journal of antibiotics

Schlüsselwörter

Cell Line
Animals
Humans
Fungi
Phenyl Ethers
Lactones
Spiro Compounds
Anti-Inflammatory Agents
Nuclear Magnetic Resonance, Biomolecular
Spectrometry, Mass, Electrospray Ionization
Transfection
Inhibitory Concentration 50
Cell Survival
Molecular Structure
Dose-Response Relationship, Drug
Chemokine CXCL10

Sprache

eng

Medium

Print-Electronic

Online publication date

2012

Paginierung

473 - 477

Datum der Veröffentlichung

2012

Status

Published

Datum der Datenerfassung

2012

Titel

3'-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a Steganospora species.

Sub types

Research Support, Non-U.S. Gov't
Journal Article

Ausgabe der Zeitschrift

65

Datenquelle: Europe PubMed Central

Abstract

CXCL10 (IP-10) is a highly inducible chemoattractant, which contributes to the recruitment of inflammatory cells such as macrophages and T-lymphocytes and thereby has important roles in chronic inflammatory conditions. In a search for new inhibitors of CXCL10 expression in MonoMac6 (MM6) cells, the new diaryl ether 3'-demethyldihydromaldoxin (1) along with the known compound dihydromaldoxin (2), were isolated from fermentations of a Steganospora species. The structures of the compounds were elucidated by a combination of one- and two-dimensional NMR spectroscopy and mass spectrometry. Compounds (1) and (2) inhibited lipopolysaccharide (LPS)/interferon-γ (IFN-γ)-induced CXCL10 promoter activity in transiently transfected MM6 cells in a dose-dependent manner with IC(50) values of 39-41 μM and also reduced LPS/IFN-γ-induced CXCL10 protein synthesis and excretion.

Autoren

Dominik Schreiber
Mathias Jung
Louis P Sandjo
Johannes C Liermann
Till Opatz
Gerhard Erkel

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/22692347

DOI

10.1038/ja.2012.46

eISSN

1881-1469

Ausgabe der Veröffentlichung

9

Zeitschrift

J Antibiot (Tokyo)

Schlüsselwörter

Animals
Anti-Inflammatory Agents
Cell Line
Cell Survival
Chemokine CXCL10
Dose-Response Relationship, Drug
Fungi
Humans
Inhibitory Concentration 50
Lactones
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Phenyl Ethers
Spectrometry, Mass, Electrospray Ionization
Spiro Compounds
Transfection

Sprache

eng

Country

England

Paginierung

473 - 477

PII

ja201246

Datum der Veröffentlichung

2012

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2013

Titel

3'-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a Steganospora species.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

65

Datenquelle: PubMed

3 '-demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory Diaryl ethers from a steganospora species

Werkzeuge