Altered functional connectivity between emotional and cognitive resting state networks in euthymic bipolar I disorder patients

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
Sammlungen
  • metadata
ISSN
1932-6203
Ausgabe der Veröffentlichung
10
Zeitschrift
PLoS one
Schlüsselwörter
  • 150 Psychologie
  • 150 Psychology
Sprache
eng
Paginierung
e107829
Datum der Veröffentlichung
2014
Herausgeber
PLoS
Herausgeber URL
http://dx.doi.org/10.1371/journal.pone.0107829
Datum der Datenerfassung
2020
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Zugang
Public
Titel
Altered functional connectivity between emotional and cognitive resting state networks in euthymic bipolar I disorder patients
Ausgabe der Zeitschrift
9

Datenquelle: METADATA.UB

Andere Metadatenquellen:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000343943500003&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1371/journal.pone.0107829
Externe Identifier
  • Clarivate Analytics Document Solution ID: AS0BL
  • PubMed Identifier: 25343370
ISSN
1932-6203
Ausgabe der Veröffentlichung
10
Zeitschrift
PLOS ONE
Artikelnummer
ARTN e107829
Datum der Veröffentlichung
2014
Status
Published
Titel
Altered Functional Connectivity between Emotional and Cognitive Resting State Networks in Euthymic Bipolar I Disorder Patients
Sub types
  • Article
Ausgabe der Zeitschrift
9

Datenquelle: Web of Science (Lite)

Autoren
DOI
10.1371/journal.pone.0107829
Editoren
  • Andreas Reif
eISSN
1932-6203
Ausgabe der Veröffentlichung
10
Zeitschrift
PLoS ONE
Sprache
en
Online publication date
2014
Paginierung
e107829 - e107829
Status
Published online
Herausgeber
Public Library of Science (PLoS)
Herausgeber URL
http://dx.doi.org/10.1371/journal.pone.0107829
Datum der Datenerfassung
2023
Titel
Altered Functional Connectivity between Emotional and Cognitive Resting State Networks in Euthymic Bipolar I Disorder Patients
Ausgabe der Zeitschrift
9

Datenquelle: Crossref

Abstract
Bipolar disorder is characterized by a functional imbalance between hyperactive ventral/limbic areas and hypoactive dorsal/cognitive brain regions potentially contributing to affective and cognitive symptoms. Resting-state studies in bipolar disorder have identified abnormal functional connectivity between these brain regions. However, most of these studies used a seed-based approach, thus restricting the number of regions that were analyzed. Using data-driven approaches, researchers identified resting state networks whose spatial maps overlap with frontolimbic areas such as the default mode network, the frontoparietal networks, the salient network, and the meso/paralimbic network. These networks are specifically engaged during affective and cognitive tasks and preliminary evidence suggests that functional connectivity within and between some of these networks is impaired in bipolar disorder. The present study used independent component analysis and functional network connectivity approaches to investigate functional connectivity within and between these resting state networks in bipolar disorder. We compared 30 euthymic bipolar I disorder patients and 35 age- and gender-matched healthy controls. Inter-network connectivity analysis revealed increased functional connectivity between the meso/paralimbic and the right frontoparietal network in bipolar disorder. This abnormal connectivity pattern did not correlate with variables related to the clinical course of the disease. The present finding may reflect abnormal integration of affective and cognitive information in ventral-emotional and dorsal-cognitive networks in euthymic bipolar patients. Furthermore, the results provide novel insights into the role of the meso/paralimbic network in bipolar disorder.
Addresses
  • Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg-University Mainz, Mainz, Germany.
Autoren
DOI
10.1371/journal.pone.0107829
eISSN
1932-6203
Externe Identifier
  • PubMed Identifier: 25343370
  • PubMed Central ID: PMC4208743
Open access
true
ISSN
1932-6203
Ausgabe der Veröffentlichung
10
Zeitschrift
PloS one
Schlüsselwörter
  • Amygdala
  • Prefrontal Cortex
  • Nerve Net
  • Humans
  • Magnetic Resonance Imaging
  • Radiography
  • Depression
  • Emotions
  • Cognition
  • Bipolar Disorder
  • Adult
  • Middle Aged
  • Female
  • Male
  • Cognitive Dysfunction
Sprache
eng
Medium
Electronic-eCollection
Online publication date
2014
Open access status
Open Access
Paginierung
e107829
Datum der Veröffentlichung
2014
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2014
Titel
Altered functional connectivity between emotional and cognitive resting state networks in euthymic bipolar I disorder patients.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
9

Files

https://europepmc.org/articles/pmc4208743?pdf=render

Datenquelle: Europe PubMed Central

Abstract
Bipolar disorder is characterized by a functional imbalance between hyperactive ventral/limbic areas and hypoactive dorsal/cognitive brain regions potentially contributing to affective and cognitive symptoms. Resting-state studies in bipolar disorder have identified abnormal functional connectivity between these brain regions. However, most of these studies used a seed-based approach, thus restricting the number of regions that were analyzed. Using data-driven approaches, researchers identified resting state networks whose spatial maps overlap with frontolimbic areas such as the default mode network, the frontoparietal networks, the salient network, and the meso/paralimbic network. These networks are specifically engaged during affective and cognitive tasks and preliminary evidence suggests that functional connectivity within and between some of these networks is impaired in bipolar disorder. The present study used independent component analysis and functional network connectivity approaches to investigate functional connectivity within and between these resting state networks in bipolar disorder. We compared 30 euthymic bipolar I disorder patients and 35 age- and gender-matched healthy controls. Inter-network connectivity analysis revealed increased functional connectivity between the meso/paralimbic and the right frontoparietal network in bipolar disorder. This abnormal connectivity pattern did not correlate with variables related to the clinical course of the disease. The present finding may reflect abnormal integration of affective and cognitive information in ventral-emotional and dorsal-cognitive networks in euthymic bipolar patients. Furthermore, the results provide novel insights into the role of the meso/paralimbic network in bipolar disorder.
Date of acceptance
2014
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/25343370
DOI
10.1371/journal.pone.0107829
eISSN
1932-6203
Externe Identifier
  • PubMed Central ID: PMC4208743
Ausgabe der Veröffentlichung
10
Zeitschrift
PLoS One
Schlüsselwörter
  • Adult
  • Amygdala
  • Bipolar Disorder
  • Cognition
  • Cognitive Dysfunction
  • Depression
  • Emotions
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nerve Net
  • Prefrontal Cortex
  • Radiography
Sprache
eng
Country
United States
Paginierung
e107829
PII
PONE-D-13-41277
Datum der Veröffentlichung
2014
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2015
Titel
Altered functional connectivity between emotional and cognitive resting state networks in euthymic bipolar I disorder patients.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
9

Datenquelle: PubMed

Author's licence
CC-BY
Autoren
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-OA-Publizieren (2012 - 2017)
Resource version
Published version
DOI
10.1371/journal.pone.0107829
Funding acknowledgements
  • DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
File(s) embargoed
false
Open access
true
ISSN
1932-6203
Ausgabe der Veröffentlichung
10
Zeitschrift
PLoS one
Schlüsselwörter
  • 150 Psychologie
  • 150 Psychology
Sprache
eng
Open access status
Open Access
Paginierung
e107829
Datum der Veröffentlichung
2014
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/7598
Herausgeber
PLoS
Herausgeber URL
http://dx.doi.org/10.1371/journal.pone.0107829
Datum der Datenerfassung
2022
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Zugang
Public
Titel
Altered functional connectivity between emotional and cognitive resting state networks in euthymic bipolar I disorder patients
Ausgabe der Zeitschrift
9

Files

altered_functional_connectivi-20220817172355514.pdf

Datenquelle: OPENSCIENCE.UB

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