Effects of clopidogrel, prasugrel and ticagrelor on endothelial function, inflammatory and oxidative stress parameters and platelet function in patients undergoing coronary artery stenting for an acute coronary syndrome : a randomised, prospective, controlled study
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Boris Schnorbus
- Andreas Daiber
- Kerstin Jurk
- Silke Warnke
- Jochem König
- Ulrike Krahn
- Karl J Lackner
- Thomas Münzel
- Tommaso Gori
- Sammlungen
- metadata
- ISSN
- 2044-6055
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- BMJ open
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Paginierung
- e005268
- Datum der Veröffentlichung
- 2014
- Herausgeber
- BMJ Publishing Group
- Herausgeber URL
- http://dx.doi.org/10.1136/bmjopen-2014-005268
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Effects of clopidogrel, prasugrel and ticagrelor on endothelial function, inflammatory and oxidative stress parameters and platelet function in patients undergoing coronary artery stenting for an acute coronary syndrome : a randomised, prospective, controlled study
- Ausgabe der Zeitschrift
- 4
Datenquelle: METADATA.UB
- Andere Metadatenquellen:
-
- Abstract
- <jats:sec><jats:title>Introduction</jats:title><jats:p>Particularly in the setting of acute coronary syndromes, the interplay between vascular and platelet function has been postulated to have direct clinical implications. The present trial is designed to test the effect of clopidogrel, prasugrel and ticagrelor on multiple parameters of vascular function, platelet aggregation, oxidative and inflammatory stress before and up to 4 weeks after coronary artery stenting.</jats:p></jats:sec><jats:sec><jats:title>Methods and analysis</jats:title><jats:p>The study is designed as a three-arm, parallel design, randomised, investigator-blinded study. Patients with unstable angina or non-ST elevation myocardial infarction undergoing coronary intervention with a drug-eluting stent will be randomised to receive 600 mg clopidogrel, 60 mg prasugrel or 180 mg ticagrelor followed by oral therapy with the same drug. The primary endpoint of the trial is the impact of antiplatelet treatments on endothelial function as assessed by flow-mediated dilation at 1 day, 1 week and 1 month in patients who have undergone stenting. Secondary endpoints include the impact of study medications on parameters of macrovascular and microvascular function, platelet reactivity, oxidative and inflammatory stress. The study recruitment is currently ongoing and, after an interim analysis which was performed at 50% of the initially planned population, it is planned to continue until July 2015.</jats:p></jats:sec><jats:sec><jats:title>Ethics and dissemination</jats:title><jats:p>The protocol was approved by the local ethics committee. The trial will provide important pathophysiological insight on the relationship between platelet aggregation and endothelial function, two parameters that have been shown to influence patients’ prognosis.</jats:p></jats:sec><jats:sec><jats:title>Trial registration number</jats:title><jats:p>ClinicalTrials.gov Identifier:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="clintrialgov" xlink:href="NCT01700322">NCT01700322</jats:ext-link>; EudraCT-Nr.: 2011-005305-73. Current V.1.3, from 24 February 2014.</jats:p></jats:sec>
- Date of acceptance
- 2014
- Autoren
- Boris Schnorbus
- Andreas Daiber
- Kerstin Jurk
- Silke Warnke
- Jochem König
- Ulrike Krahn
- Karl Lackner
- Thomas Munzel
- Tommaso Gori
- DOI
- 10.1136/bmjopen-2014-005268
- eISSN
- 2044-6055
- ISSN
- 2044-6055
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- BMJ Open
- Sprache
- en
- Online publication date
- 2014
- Paginierung
- e005268 - e005268
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Herausgeber
- BMJ
- Herausgeber URL
- http://dx.doi.org/10.1136/bmjopen-2014-005268
- Datum der Datenerfassung
- 2024
- Titel
- Effects of clopidogrel, prasugrel and ticagrelor on endothelial function, inflammatory and oxidative stress parameters and platelet function in patients undergoing coronary artery stenting for an acute coronary syndrome. A randomised, prospective, controlled study
- Ausgabe der Zeitschrift
- 4
Datenquelle: Crossref
- Author's licence
- CC-BY-NC
- Autoren
- Boris Schnorbus
- Andreas Daiber
- Kerstin Jurk
- Silke Warnke
- Jochem König
- Ulrike Krahn
- Karl J Lackner
- Thomas Münzel
- Tommaso Gori
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- DFG-OA-Publizieren (2012 - 2017)
- Resource version
- Published version
- DOI
- 10.1136/bmjopen-2014-005268
- Funding acknowledgements
- DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 2044-6055
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- BMJ open
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- e005268
- Datum der Veröffentlichung
- 2014
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/7767
- Herausgeber
- BMJ Publishing Group
- Herausgeber URL
- http://dx.doi.org/10.1136/bmjopen-2014-005268
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- Effects of clopidogrel, prasugrel and ticagrelor on endothelial function, inflammatory and oxidative stress parameters and platelet function in patients undergoing coronary artery stenting for an acute coronary syndrome : a randomised, prospective, controlled study
- Ausgabe der Zeitschrift
- 4
Files
effects_of_clopidogrel_prasug-20220913191746559.pdf
Datenquelle: OPENSCIENCE.UB