Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax : a liver transcriptomics approach
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Hanno Schmidt
- Assaf Malik
- Anne Bicker
- Gesa Poetzsch
- Aaron Avivi
- Imad Shams
- Thomas Hankeln
- Sammlungen
- metadata
- ISSN
- 2045-2322
- Zeitschrift
- Scientific reports
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Paginierung
- Art. 14348
- Datum der Veröffentlichung
- 2017
- Herausgeber
- Nature Publ. Group
- Herausgeber URL
- http://dx.doi.org/10.1038/s41598-017-13905-z
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax : a liver transcriptomics approach
- Ausgabe der Zeitschrift
- 7
Datenquelle: METADATA.UB
- Andere Metadatenquellen:
-
- Autoren
- Hanno Schmidt
- Assaf Malik
- Anne Bicker
- Gesa Poetzsch
- Aaron Avivi
- Imad Shams
- Thomas Hankeln
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000414131700041&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1038/s41598-017-13905-z
- Externe Identifier
- Clarivate Analytics Document Solution ID: FL3OC
- PubMed Identifier: 29084988
- ISSN
- 2045-2322
- Zeitschrift
- SCIENTIFIC REPORTS
- Artikelnummer
- ARTN 14348
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Titel
- Hypoxia tolerance, longevity and cancer-resistance in the mole rat <i>Spalax</i> - a liver transcriptomics approach
- Sub types
- Article
- Ausgabe der Zeitschrift
- 7
Datenquelle: Web of Science (Lite)
- Abstract
- <jats:title>Abstract</jats:title><jats:p>The blind subterranean mole rat <jats:italic>Spalax</jats:italic> shows a remarkable tolerance to hypoxia, cancer-resistance and longevity. Unravelling the genomic basis of these adaptations will be important for biomedical applications. RNA-Seq gene expression data were obtained from normoxic and hypoxic <jats:italic>Spalax</jats:italic> and rat liver tissue. Hypoxic <jats:italic>Spalax</jats:italic> broadly downregulates genes from major liver function pathways. This energy-saving response is likely a crucial adaptation to low oxygen levels. In contrast, the hypoxia-sensitive rat shows massive upregulation of energy metabolism genes. Candidate genes with plausible connections to the mole rat’s phenotype, such as important key genes related to hypoxia-tolerance, DNA damage repair, tumourigenesis and ageing, are substantially higher expressed in <jats:italic>Spalax</jats:italic> than in rat. Comparative liver transcriptomics highlights the importance of molecular adaptations at the gene regulatory level in <jats:italic>Spalax</jats:italic> and pinpoints a variety of starting points for subsequent functional studies.</jats:p>
- Autoren
- Hanno Schmidt
- Assaf Malik
- Anne Bicker
- Gesa Poetzsch
- Aaron Avivi
- Imad Shams
- Thomas Hankeln
- DOI
- 10.1038/s41598-017-13905-z
- eISSN
- 2045-2322
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Scientific Reports
- Sprache
- en
- Artikelnummer
- 14348
- Online publication date
- 2017
- Status
- Published online
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/s41598-017-13905-z
- Datum der Datenerfassung
- 2022
- Titel
- Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax – a liver transcriptomics approach
- Ausgabe der Zeitschrift
- 7
Datenquelle: Crossref
- Abstract
- The blind subterranean mole rat Spalax shows a remarkable tolerance to hypoxia, cancer-resistance and longevity. Unravelling the genomic basis of these adaptations will be important for biomedical applications. RNA-Seq gene expression data were obtained from normoxic and hypoxic Spalax and rat liver tissue. Hypoxic Spalax broadly downregulates genes from major liver function pathways. This energy-saving response is likely a crucial adaptation to low oxygen levels. In contrast, the hypoxia-sensitive rat shows massive upregulation of energy metabolism genes. Candidate genes with plausible connections to the mole rat's phenotype, such as important key genes related to hypoxia-tolerance, DNA damage repair, tumourigenesis and ageing, are substantially higher expressed in Spalax than in rat. Comparative liver transcriptomics highlights the importance of molecular adaptations at the gene regulatory level in Spalax and pinpoints a variety of starting points for subsequent functional studies.
- Addresses
- Molecular Genetics and Genome Analysis, Institute of Organismic and Molecular Evolution, Johannes Gutenberg-University, Johann Joachim Becher-Weg 30 A, D-55128, Mainz, Germany.
- Autoren
- Hanno Schmidt
- Assaf Malik
- Anne Bicker
- Gesa Poetzsch
- Aaron Avivi
- Imad Shams
- Thomas Hankeln
- DOI
- 10.1038/s41598-017-13905-z
- eISSN
- 2045-2322
- Externe Identifier
- PubMed Identifier: 29084988
- PubMed Central ID: PMC5662568
- Open access
- true
- ISSN
- 2045-2322
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Scientific reports
- Schlüsselwörter
- Liver
- Animals
- Mole Rats
- Spalax
- Rats
- Sequence Analysis, RNA
- Adaptation, Physiological
- Species Specificity
- Immune Tolerance
- DNA Repair
- Energy Metabolism
- Aging
- Longevity
- Drug Tolerance
- Transcriptome
- Hypoxia
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2017
- Open access status
- Open Access
- Paginierung
- 14348
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2017
- Titel
- Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax - a liver transcriptomics approach.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 7
Files
https://www.nature.com/articles/s41598-017-13905-z.pdf https://europepmc.org/articles/PMC5662568?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- The blind subterranean mole rat Spalax shows a remarkable tolerance to hypoxia, cancer-resistance and longevity. Unravelling the genomic basis of these adaptations will be important for biomedical applications. RNA-Seq gene expression data were obtained from normoxic and hypoxic Spalax and rat liver tissue. Hypoxic Spalax broadly downregulates genes from major liver function pathways. This energy-saving response is likely a crucial adaptation to low oxygen levels. In contrast, the hypoxia-sensitive rat shows massive upregulation of energy metabolism genes. Candidate genes with plausible connections to the mole rat's phenotype, such as important key genes related to hypoxia-tolerance, DNA damage repair, tumourigenesis and ageing, are substantially higher expressed in Spalax than in rat. Comparative liver transcriptomics highlights the importance of molecular adaptations at the gene regulatory level in Spalax and pinpoints a variety of starting points for subsequent functional studies.
- Date of acceptance
- 2017
- Autoren
- Hanno Schmidt
- Assaf Malik
- Anne Bicker
- Gesa Poetzsch
- Aaron Avivi
- Imad Shams
- Thomas Hankeln
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/29084988
- DOI
- 10.1038/s41598-017-13905-z
- eISSN
- 2045-2322
- Externe Identifier
- PubMed Central ID: PMC5662568
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Sci Rep
- Schlüsselwörter
- Adaptation, Physiological
- Aging
- Animals
- DNA Repair
- Drug Tolerance
- Energy Metabolism
- Hypoxia
- Immune Tolerance
- Liver
- Longevity
- Mole Rats
- Rats
- Sequence Analysis, RNA
- Spalax
- Species Specificity
- Transcriptome
- Sprache
- eng
- Country
- England
- Paginierung
- 14348
- PII
- 10.1038/s41598-017-13905-z
- Datum der Veröffentlichung
- 2017
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2019
- Titel
- Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax - a liver transcriptomics approach.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 7
Datenquelle: PubMed
- Author's licence
- CC-BY
- Autoren
- Hanno Schmidt
- Assaf Malik
- Anne Bicker
- Gesa Poetzsch
- Aaron Avivi
- Imad Shams
- Thomas Hankeln
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- DFG-OA-Publizieren (2012 - 2017)
- Resource version
- Published version
- DOI
- 10.1038/s41598-017-13905-z
- Funding acknowledgements
- DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 2045-2322
- Zeitschrift
- Scientific reports
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- Art. 14348
- Datum der Veröffentlichung
- 2017
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/7364
- Herausgeber
- Nature Publ. Group
- Herausgeber URL
- http://dx.doi.org/10.1038/s41598-017-13905-z
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax : a liver transcriptomics approach
- Ausgabe der Zeitschrift
- 7
Files
hypoxia_tolerance_longevity_a-20220710210813470.pdf
Datenquelle: OPENSCIENCE.UB
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