Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targets

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Nicole Comtesse
  • Andrea Zippel
  • Sascha Walle
  • Dominik Monz
  • Christina Backes
  • Ulrike Fischer
  • Jens Mayer
  • Nicole Ludwig
  • Andreas Hildebrandt
  • Andreas Keller
  • Wolf-Ingo Steudel
  • Hans-Peter Lenhof
  • Eckart Meese
Sammlungen
  • metadata
ISSN
1091-6490
Ausgabe der Veröffentlichung
27
Zeitschrift
Proceedings of the National Academy of Sciences of the United States of America
Schlüsselwörter
  • 004 Informatik
  • 004 Data processing
Sprache
eng
Paginierung
Seiten: 9601 - 9606
Datum der Veröffentlichung
2005
Herausgeber
National Acad. of Sciences
Herausgeber URL
http://dx.doi.org/10.1073/pnas.0500404102
Datum der Datenerfassung
2020
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Zugang
Public
Titel
Complex humoral immune response against a benign tumor : frequent antibody response against specific antigens as diagnostic targets
Ausgabe der Zeitschrift
102

Datenquelle: METADATA.UB

Andere Metadatenquellen:
Autoren
  • N Comtesse
  • A Zippel
  • S Walle
  • D Monz
  • C Backes
  • U Fischer
  • J Mayer
  • N Ludwig
  • A Hildebrandt
  • A Keller
  • WI Steudel
  • HP Lenhof
  • E Meese
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000230406000030&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1073/pnas.0500404102
Externe Identifier
  • Clarivate Analytics Document Solution ID: 944DN
  • PubMed Identifier: 15983380
ISSN
0027-8424
Ausgabe der Veröffentlichung
27
Zeitschrift
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Schlüsselwörter
  • meningioma
Paginierung
9601 - 9606
Datum der Veröffentlichung
2005
Status
Published
Titel
Complex humoral immune response against a benign tumor: Frequent antibody response against specific antigens as diagnostic targets
Sub types
  • Article
Ausgabe der Zeitschrift
102

Datenquelle: Web of Science (Lite)

Abstract
<jats:p> There are numerous studies on the immune response against malignant human tumors. This study was aimed to address the complexity and specificity of humoral immune response against a benign human tumor. We assembled a panel of 62 meningioma-expressed antigens that show reactivity with serum antibodies of meningioma patients, including 41 previously uncharacterized antigens by screening of a fetal brain expression library. We tested the panel for reactivity with 48 sera, including sera of patients with common-type, atypical, and anaplastic meningioma, respectively. Meningioma sera detected an average of 14.6 antigens per serum and normal sera an average of 7.8 antigens per serum ( <jats:italic>P</jats:italic> = 0.0001). We found a decline of seroreactivity with malignancy with a statistical significant difference between common-type and anaplastic meningioma ( <jats:italic>P</jats:italic> &lt; 0.05). We detected 17 antigens exclusively with patient sera, including 12 sera that were reactive against KIAA1344, 9 against natural killer tumor recognition (NKTR), and 7 against SRY (sex determining region Y)-box2 (SOX2). More than 80% of meningioma patients had antibodies against at least one of the antigens KIAA1344, SC65, SOX2, and C6orf153. Our results show a highly complex but specific humoral immune response against a benign tumor with a distinct serum reactivity pattern and a decline of complexity with malignancy. The frequent antibody response against specific antigens offers new diagnostic and therapeutic targets for meningioma. We developed a statistical learning method to differentiate sera of meningioma patients from sera of healthy donors. </jats:p>
Autoren
  • Nicole Comtesse
  • Andrea Zippel
  • Sascha Walle
  • Dominik Monz
  • Christina Backes
  • Ulrike Fischer
  • Jens Mayer
  • Nicole Ludwig
  • Andreas Hildebrandt
  • Andreas Keller
  • Wolf-Ingo Steudel
  • Hans-Peter Lenhof
  • Eckart Meese
DOI
10.1073/pnas.0500404102
eISSN
1091-6490
ISSN
0027-8424
Ausgabe der Veröffentlichung
27
Zeitschrift
Proceedings of the National Academy of Sciences
Sprache
en
Online publication date
2005
Paginierung
9601 - 9606
Datum der Veröffentlichung
2005
Status
Published
Herausgeber
Proceedings of the National Academy of Sciences
Herausgeber URL
http://dx.doi.org/10.1073/pnas.0500404102
Datum der Datenerfassung
2022
Titel
Complex humoral immune response against a benign tumor: Frequent antibody response against specific antigens as diagnostic targets
Ausgabe der Zeitschrift
102

Datenquelle: Crossref

Abstract
There are numerous studies on the immune response against malignant human tumors. This study was aimed to address the complexity and specificity of humoral immune response against a benign human tumor. We assembled a panel of 62 meningioma-expressed antigens that show reactivity with serum antibodies of meningioma patients, including 41 previously uncharacterized antigens by screening of a fetal brain expression library. We tested the panel for reactivity with 48 sera, including sera of patients with common-type, atypical, and anaplastic meningioma, respectively. Meningioma sera detected an average of 14.6 antigens per serum and normal sera an average of 7.8 antigens per serum (P = 0.0001). We found a decline of seroreactivity with malignancy with a statistical significant difference between common-type and anaplastic meningioma (P < 0.05). We detected 17 antigens exclusively with patient sera, including 12 sera that were reactive against KIAA1344, 9 against natural killer tumor recognition (NKTR), and 7 against SRY (sex determining region Y)-box2 (SOX2). More than 80% of meningioma patients had antibodies against at least one of the antigens KIAA1344, SC65, SOX2, and C6orf153. Our results show a highly complex but specific humoral immune response against a benign tumor with a distinct serum reactivity pattern and a decline of complexity with malignancy. The frequent antibody response against specific antigens offers new diagnostic and therapeutic targets for meningioma. We developed a statistical learning method to differentiate sera of meningioma patients from sera of healthy donors.
Addresses
  • Department of Human Genetics, Medical School, University of Saarland, Building 60, 66421 Homburg/Saar, Germany.
Autoren
  • Nicole Comtesse
  • Andrea Zippel
  • Sascha Walle
  • Dominik Monz
  • Christina Backes
  • Ulrike Fischer
  • Jens Mayer
  • Nicole Ludwig
  • Andreas Hildebrandt
  • Andreas Keller
  • Wolf-Ingo Steudel
  • Hans-Peter Lenhof
  • Eckart Meese
DOI
10.1073/pnas.0500404102
eISSN
1091-6490
Externe Identifier
  • PubMed Identifier: 15983380
  • PubMed Central ID: PMC1172238
Open access
false
ISSN
0027-8424
Ausgabe der Veröffentlichung
27
Zeitschrift
Proceedings of the National Academy of Sciences of the United States of America
Schlüsselwörter
  • Brain
  • Meninges
  • Humans
  • Meningioma
  • DNA Primers
  • Antibodies, Neoplasm
  • Antigens, Neoplasm
  • Serologic Tests
  • Discriminant Analysis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Antibody Formation
  • Antibody Specificity
  • Gene Library
Sprache
eng
Medium
Print-Electronic
Online publication date
2005
Paginierung
9601 - 9606
Datum der Veröffentlichung
2005
Status
Published
Datum der Datenerfassung
2005
Titel
Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targets.
Sub types
  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
102

Files

https://europepmc.org/articles/PMC1172238?pdf=render

Datenquelle: Europe PubMed Central

Abstract
There are numerous studies on the immune response against malignant human tumors. This study was aimed to address the complexity and specificity of humoral immune response against a benign human tumor. We assembled a panel of 62 meningioma-expressed antigens that show reactivity with serum antibodies of meningioma patients, including 41 previously uncharacterized antigens by screening of a fetal brain expression library. We tested the panel for reactivity with 48 sera, including sera of patients with common-type, atypical, and anaplastic meningioma, respectively. Meningioma sera detected an average of 14.6 antigens per serum and normal sera an average of 7.8 antigens per serum (P = 0.0001). We found a decline of seroreactivity with malignancy with a statistical significant difference between common-type and anaplastic meningioma (P < 0.05). We detected 17 antigens exclusively with patient sera, including 12 sera that were reactive against KIAA1344, 9 against natural killer tumor recognition (NKTR), and 7 against SRY (sex determining region Y)-box2 (SOX2). More than 80% of meningioma patients had antibodies against at least one of the antigens KIAA1344, SC65, SOX2, and C6orf153. Our results show a highly complex but specific humoral immune response against a benign tumor with a distinct serum reactivity pattern and a decline of complexity with malignancy. The frequent antibody response against specific antigens offers new diagnostic and therapeutic targets for meningioma. We developed a statistical learning method to differentiate sera of meningioma patients from sera of healthy donors.
Autoren
  • Nicole Comtesse
  • Andrea Zippel
  • Sascha Walle
  • Dominik Monz
  • Christina Backes
  • Ulrike Fischer
  • Jens Mayer
  • Nicole Ludwig
  • Andreas Hildebrandt
  • Andreas Keller
  • Wolf-Ingo Steudel
  • Hans-Peter Lenhof
  • Eckart Meese
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/15983380
DOI
10.1073/pnas.0500404102
Externe Identifier
  • PubMed Central ID: PMC1172238
ISSN
0027-8424
Ausgabe der Veröffentlichung
27
Zeitschrift
Proc Natl Acad Sci U S A
Schlüsselwörter
  • Antibodies, Neoplasm
  • Antibody Formation
  • Antibody Specificity
  • Antigens, Neoplasm
  • Brain
  • DNA Primers
  • Discriminant Analysis
  • Gene Library
  • Humans
  • Meninges
  • Meningioma
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Serologic Tests
Sprache
eng
Country
United States
Paginierung
9601 - 9606
PII
0500404102
Datum der Veröffentlichung
2005
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2005
Titel
Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targets.
Sub types
  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
102

Datenquelle: PubMed

Autoren
  • Nicole Comtesse
  • Andrea Zippel
  • Sascha Walle
  • Dominik Monz
  • Christina Backes
  • Ulrike Fischer
  • Jens Mayer
  • Nicole Ludwig
  • Andreas Hildebrandt
  • Andreas Keller
  • others
Zeitschrift
Proceedings of the National Academy of Sciences
Artikelnummer
27
Paginierung
9601 - 9606
Datum der Veröffentlichung
2005
Herausgeber
National Academy of Sciences
Datum der Datenerfassung
2020
Titel
Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targets
Sub types
  • article
Ausgabe der Zeitschrift
102

Datenquelle: Manual

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