A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Amgad Droby
- Michail Panagoulias
- Philipp Albrecht
- Eva Reuter
- Thomas Duning
- Andreas Hildebrandt
- Heinz Wiendl
- Frauke Zipp
- Axel Methner
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000372469300009&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1136/bjophthalmol-2014-306015
- eISSN
- 1468-2079
- Externe Identifier
- Clarivate Analytics Document Solution ID: DH0JA
- PubMed Identifier: 26307452
- ISSN
- 0007-1161
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- BRITISH JOURNAL OF OPHTHALMOLOGY
- Paginierung
- 484 - 490
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis
- Sub types
- Article
- Ausgabe der Zeitschrift
- 100
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Amgad Droby
- Michail Panagoulias
- Philipp Albrecht
- Eva Reuter
- Thomas Duning
- Andreas Hildebrandt
- Heinz Wiendl
- Frauke Zipp
- Axel Methner
- DOI
- 10.1136/bjophthalmol-2014-306015
- eISSN
- 1468-2079
- ISSN
- 0007-1161
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- British Journal of Ophthalmology
- Sprache
- en
- Online publication date
- 2015
- Paginierung
- 484 - 490
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Herausgeber
- BMJ
- Herausgeber URL
- http://dx.doi.org/10.1136/bjophthalmol-2014-306015
- Datum der Datenerfassung
- 2020
- Titel
- A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis
- Ausgabe der Zeitschrift
- 100
Datenquelle: Crossref
- Abstract
- <h4>Aim</h4>The evaluation of inner retinal layer thickness can serve as a direct biomarker for monitoring the course of inflammatory diseases of the central nervous system such as multiple sclerosis (MS). Using optical coherence tomography (OCT), thinning of the retinal nerve fibre layer and changes in deeper retinal layers have been observed in patients with MS. Here, we first compare a novel method for automated segmentation of OCT images with manual segmentation using two cohorts of patients with MS. Using this method, we also aimed to reproduce previous findings showing retinal degeneration following optic neuritis (ON) in MS.<h4>Methods</h4>Based on a 5×5 expansion of the Prewitt operator to efficiently calculate the gradient of image intensity, we introduce an automated algorithm for the segmentation of intraretinal layers. We evaluated this algorithm by comparison to manually segmented two-dimensional OCT images at the macular level for 125 patients from two separate cohorts of patients with MS. Of these patients, 52 had suffered from unilateral ON+ within 6 months prior to measurement.<h4>Results</h4>When comparing ON+ eyes with ON- eyes, both manual and automated segmentation demonstrated a significant inter-eye thinning in the ganglion cell layer in ON+ eyes. We also observed an increased thickness of the inner nuclear (INL) and the outer segment-retinal pigment epithelium (OS-RPE) layers of ON+ eyes in both cohorts. These findings corroborate previous data, thus demonstrating the validity of our approach.<h4>Conclusions</h4>The algorithm presented here was found to be a valid tool for replacing cumbersome manual segmentation methods in the quantification of inner retinal layers in OCT. The observed increases in thickness of INL and OS-RPE may be attributed to primary retinal inflammation, repair and/or plasticity mechanisms following the immune attack.
- Addresses
- Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University, Mainz, Germany.
- Autoren
- Amgad Droby
- Michail Panagoulias
- Philipp Albrecht
- Eva Reuter
- Thomas Duning
- Andreas Hildebrandt
- Heinz Wiendl
- Frauke Zipp
- Axel Methner
- DOI
- 10.1136/bjophthalmol-2014-306015
- eISSN
- 1468-2079
- Externe Identifier
- PubMed Identifier: 26307452
- Open access
- false
- ISSN
- 0007-1161
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- The British journal of ophthalmology
- Schlüsselwörter
- Nerve Fibers
- Humans
- Multiple Sclerosis
- Optic Neuritis
- Retinal Degeneration
- Tomography, Optical Coherence
- Diagnostic Techniques, Ophthalmological
- Reproducibility of Results
- Algorithms
- Adult
- Middle Aged
- Female
- Male
- Retinal Neurons
- Young Adult
- Biomarkers
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2015
- Paginierung
- 484 - 490
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum der Datenerfassung
- 2015
- Titel
- A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis.
- Sub types
- Validation Study
- Journal Article
- Ausgabe der Zeitschrift
- 100
Datenquelle: Europe PubMed Central
- Abstract
- AIM: The evaluation of inner retinal layer thickness can serve as a direct biomarker for monitoring the course of inflammatory diseases of the central nervous system such as multiple sclerosis (MS). Using optical coherence tomography (OCT), thinning of the retinal nerve fibre layer and changes in deeper retinal layers have been observed in patients with MS. Here, we first compare a novel method for automated segmentation of OCT images with manual segmentation using two cohorts of patients with MS. Using this method, we also aimed to reproduce previous findings showing retinal degeneration following optic neuritis (ON) in MS. METHODS: Based on a 5×5 expansion of the Prewitt operator to efficiently calculate the gradient of image intensity, we introduce an automated algorithm for the segmentation of intraretinal layers. We evaluated this algorithm by comparison to manually segmented two-dimensional OCT images at the macular level for 125 patients from two separate cohorts of patients with MS. Of these patients, 52 had suffered from unilateral ON+ within 6 months prior to measurement. RESULTS: When comparing ON+ eyes with ON- eyes, both manual and automated segmentation demonstrated a significant inter-eye thinning in the ganglion cell layer in ON+ eyes. We also observed an increased thickness of the inner nuclear (INL) and the outer segment-retinal pigment epithelium (OS-RPE) layers of ON+ eyes in both cohorts. These findings corroborate previous data, thus demonstrating the validity of our approach. CONCLUSIONS: The algorithm presented here was found to be a valid tool for replacing cumbersome manual segmentation methods in the quantification of inner retinal layers in OCT. The observed increases in thickness of INL and OS-RPE may be attributed to primary retinal inflammation, repair and/or plasticity mechanisms following the immune attack.
- Date of acceptance
- 2015
- Autoren
- Amgad Droby
- Michail Panagoulias
- Philipp Albrecht
- Eva Reuter
- Thomas Duning
- Andreas Hildebrandt
- Heinz Wiendl
- Frauke Zipp
- Axel Methner
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/26307452
- DOI
- 10.1136/bjophthalmol-2014-306015
- eISSN
- 1468-2079
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Br J Ophthalmol
- Schlüsselwörter
- Imaging
- Immunology
- Optic Nerve
- Pathology
- Retina
- Adult
- Algorithms
- Biomarkers
- Diagnostic Techniques, Ophthalmological
- Female
- Humans
- Male
- Middle Aged
- Multiple Sclerosis
- Nerve Fibers
- Optic Neuritis
- Reproducibility of Results
- Retinal Degeneration
- Retinal Neurons
- Tomography, Optical Coherence
- Young Adult
- Sprache
- eng
- Country
- England
- Paginierung
- 484 - 490
- PII
- bjophthalmol-2014-306015
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2016
- Titel
- A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis.
- Sub types
- Journal Article
- Validation Study
- Ausgabe der Zeitschrift
- 100
Datenquelle: PubMed
- Autoren
- Amgad Droby
- Michail Panagoulias
- Philipp Albrecht
- Eva Reuter
- Thomas Duning
- Andreas Hildebrandt
- Heinz Wiendl
- Frauke Zipp
- Axel Methner
- Zeitschrift
- British Journal of Ophthalmology
- Artikelnummer
- 4
- Paginierung
- 484 - 490
- Datum der Veröffentlichung
- 2016
- Herausgeber
- BMJ Publishing Group Ltd.
- Datum der Datenerfassung
- 2020
- Titel
- A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis
- Sub types
- article
- Ausgabe der Zeitschrift
- 100
Datenquelle: Manual
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