The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients

Autoren

Amgad Droby
Vinzenz Fleischer
Marco Carnini
Hilga Zimmermann
Volker Siffrin
Joachim Gawehn
Michael Erb
Andreas Hildebrandt
Bernhard Baier
Frauke Zipp

DOI

10.1016/j.nicl.2015.03.003

ISSN

2213-1582

Zeitschrift

NeuroImage: Clinical

Sprache

en

Paginierung

110 - 116

Datum der Veröffentlichung

2015

Status

Published

Herausgeber

Elsevier BV

Herausgeber URL

http://dx.doi.org/10.1016/j.nicl.2015.03.003

Datum der Datenerfassung

2019

Titel

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients

Ausgabe der Zeitschrift

8

Datenquelle: Crossref

Abstract

Infratentorial lesions have been assigned an equivalent weighting to supratentorial plaques in the new McDonald criteria for diagnosing multiple sclerosis. Moreover, their presence has been shown to have prognostic value for disability. However, their spatial distribution and impact on network damage is not well understood. As a preliminary step in this study, we mapped the overall infratentorial lesion pattern in relapsing-remitting multiple sclerosis patients (N = 317) using MRI, finding the pons (lesion density, 14.25/cm(3)) and peduncles (13.38/cm(3)) to be predilection sites for infratentorial lesions. Based on these results, 118 fiber bundles from 15 healthy controls and a subgroup of 23 patients showing lesions unilaterally at the predilection sites were compared using diffusion tensor imaging to analyze the impact of an isolated infratentorial lesion on the affected fiber tracts. Fractional anisotropy, mean diffusion as well as axial and radial diffusivity were investigated at the lesion site and along the entire fiber tract. Infratentorial lesions were found to have an impact on the fractional anisotropy and radial diffusivity not only at the lesion site itself but also along the entire affected fiber tract. As previously found in animal experiments, inflammatory attack in the posterior fossa in multiple sclerosis impacts the whole affected fiber tract. Here, this damaging effect, reflected by changes in diffusivity measures, was detected in vivo in multiple sclerosis patients in early stages of the disease, thus demonstrating the influence of a focal immune attack on more distant networks, and emphasizing the pathophysiological role of Wallerian degeneration in multiple sclerosis.

Addresses

Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany ; Neuroimage Center (NIC) of the Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University, Mainz, Germany.

Autoren

Amgad Droby
Vinzenz Fleischer
Marco Carnini
Hilga Zimmermann
Volker Siffrin
Joachim Gawehn
Michael Erb
Andreas Hildebrandt
Bernhard Baier
Frauke Zipp

DOI

10.1016/j.nicl.2015.03.003

eISSN

2213-1582

Externe Identifier

PubMed Identifier: 26106534
PubMed Central ID: PMC4473264

Funding acknowledgements

German Research Council (DFG: CRC-TR 128, B5
German Research Council (DFG: BA 4097/1-1
the Ministry of Science and Education (BMBF/KKNMS: B7.3

Open access

true

ISSN

2213-1582

Zeitschrift

NeuroImage. Clinical

Schlüsselwörter

Brain Stem
Nerve Fibers
Humans
Multiple Sclerosis, Relapsing-Remitting
Adult
Middle Aged
Diffusion Tensor Imaging
White Matter

Sprache

eng

Medium

Electronic-eCollection

Online publication date

2015

Open access status

Open Access

Paginierung

110 - 116

Datum der Veröffentlichung

2015

Status

Published

Publisher licence

CC BY-NC-ND

Datum der Datenerfassung

2015

Titel

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients.

Sub types

Research Support, Non-U.S. Gov't
research-article
Journal Article

Ausgabe der Zeitschrift

8

Files

https://europepmc.org/articles/PMC4473264?pdf=render

Datenquelle: Europe PubMed Central

Abstract

Infratentorial lesions have been assigned an equivalent weighting to supratentorial plaques in the new McDonald criteria for diagnosing multiple sclerosis. Moreover, their presence has been shown to have prognostic value for disability. However, their spatial distribution and impact on network damage is not well understood. As a preliminary step in this study, we mapped the overall infratentorial lesion pattern in relapsing-remitting multiple sclerosis patients (N = 317) using MRI, finding the pons (lesion density, 14.25/cm(3)) and peduncles (13.38/cm(3)) to be predilection sites for infratentorial lesions. Based on these results, 118 fiber bundles from 15 healthy controls and a subgroup of 23 patients showing lesions unilaterally at the predilection sites were compared using diffusion tensor imaging to analyze the impact of an isolated infratentorial lesion on the affected fiber tracts. Fractional anisotropy, mean diffusion as well as axial and radial diffusivity were investigated at the lesion site and along the entire fiber tract. Infratentorial lesions were found to have an impact on the fractional anisotropy and radial diffusivity not only at the lesion site itself but also along the entire affected fiber tract. As previously found in animal experiments, inflammatory attack in the posterior fossa in multiple sclerosis impacts the whole affected fiber tract. Here, this damaging effect, reflected by changes in diffusivity measures, was detected in vivo in multiple sclerosis patients in early stages of the disease, thus demonstrating the influence of a focal immune attack on more distant networks, and emphasizing the pathophysiological role of Wallerian degeneration in multiple sclerosis.

Date of acceptance

2015

Autoren

Amgad Droby
Vinzenz Fleischer
Marco Carnini
Hilga Zimmermann
Volker Siffrin
Joachim Gawehn
Michael Erb
Andreas Hildebrandt
Bernhard Baier
Frauke Zipp

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/26106534

DOI

10.1016/j.nicl.2015.03.003

eISSN

2213-1582

Externe Identifier

PubMed Central ID: PMC4473264

Zeitschrift

Neuroimage Clin

Schlüsselwörter

AD, axial diffusivity
Brainstem
Diffusion tensor imaging
EAE, experimental autoimmune encephalomyelitis
FA, fractional anisotropy
Fractional anisotropy
ICP, inferior cerebellar peduncle
LD, lesion density
LSAF, left superior arcuate fasciculus
MD, mean diffusivity
Multiple sclerosis
NAWM, normal-appearing white matter
RD, radial diffusivity
White matter
Adult
Brain Stem
Diffusion Tensor Imaging
Humans
Middle Aged
Multiple Sclerosis, Relapsing-Remitting
Nerve Fibers
White Matter

Sprache

eng

Country

Netherlands

Paginierung

110 - 116

PII

S2213-1582(15)00045-5

Datum der Veröffentlichung

2015

Status

Published online

Datum, an dem der Datensatz öffentlich gemacht wurde

2016

Titel

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

8

Datenquelle: PubMed

Autoren

Amgad Droby
Vinzenz Fleischer
Marco Carnini
Hilga Zimmermann
Volker Siffrin
Joachim Gawehn
Michael Erb
Andreas Hildebrandt
Bernhard Baier
Frauke Zipp

Zeitschrift

NeuroImage: Clinical

Paginierung

110 - 116

Datum der Veröffentlichung

2015

Herausgeber

Elsevier

Datum der Datenerfassung

2020

Titel

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients

Sub types

article

Ausgabe der Zeitschrift

8

Datenquelle: Manual

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients

Files

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