Lessons from Viruses: Controlling the Function of Transmembrane Proteins by Interfering Transmembrane Helices
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- F Cymer
- D Schneider
- DOI
- 10.2174/092986708783955545
- ISSN
- 0929-8673
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Current Medicinal Chemistry
- Sprache
- en
- Paginierung
- 779 - 785
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Herausgeber
- Bentham Science Publishers Ltd.
- Herausgeber URL
- http://dx.doi.org/10.2174/092986708783955545
- Datum der Datenerfassung
- 2015
- Titel
- Lessons from Viruses: Controlling the Function of Transmembrane Proteins by Interfering Transmembrane Helices
- Ausgabe der Zeitschrift
- 15
Datenquelle: Crossref
- Andere Metadatenquellen:
-
- Abstract
- Viral proteins sometimes interfere with human transmembrane receptors to gain access into a cell or they use transmembrane domains to interfere with cellular signal cascades in human cells. Such interference can lead to a deregulation of tightly regulated processes and eventually to different forms of cancer. There is still little knowledge about how proteins act and interact in biological membranes but the membrane environment restricts the fold and composition of membrane proteins when compared to water soluble proteins. These restrictions and a sometimes related functional principle of different viral transmembrane proteins for gaining access to a host cell or to intervene with cellular processes may offer a great opportunity to interfere with those processes in a simplified manner. A close collaboration of various disciplines may result in the development of drugs that specifically target membranes and interfere with viral transmembrane domains or even regulate the function of cellular membrane proteins. In this review we describe the function of interactions between human and viral membrane proteins in a cellular membrane, and perspectives to intervene with those processes are discussed.
- Addresses
- Institut für Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Freiburg, Germany.
- Autoren
- F Cymer
- D Schneider
- DOI
- 10.2174/092986708783955545
- eISSN
- 1875-533X
- Externe Identifier
- PubMed Identifier: 18393847
- Open access
- false
- ISSN
- 0929-8673
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Current medicinal chemistry
- Schlüsselwörter
- Cell Membrane
- Animals
- Humans
- Viruses
- Viral Matrix Proteins
- Protein Conformation
- Sprache
- eng
- Medium
- Paginierung
- 779 - 785
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Datum der Datenerfassung
- 2008
- Titel
- Lessons from viruses: controlling the function of transmembrane proteins by interfering transmembrane helices.
- Sub types
- Research Support, Non-U.S. Gov't
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 15
Datenquelle: Europe PubMed Central
- Abstract
- Viral proteins sometimes interfere with human transmembrane receptors to gain access into a cell or they use transmembrane domains to interfere with cellular signal cascades in human cells. Such interference can lead to a deregulation of tightly regulated processes and eventually to different forms of cancer. There is still little knowledge about how proteins act and interact in biological membranes but the membrane environment restricts the fold and composition of membrane proteins when compared to water soluble proteins. These restrictions and a sometimes related functional principle of different viral transmembrane proteins for gaining access to a host cell or to intervene with cellular processes may offer a great opportunity to interfere with those processes in a simplified manner. A close collaboration of various disciplines may result in the development of drugs that specifically target membranes and interfere with viral transmembrane domains or even regulate the function of cellular membrane proteins. In this review we describe the function of interactions between human and viral membrane proteins in a cellular membrane, and perspectives to intervene with those processes are discussed.
- Autoren
- F Cymer
- D Schneider
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/18393847
- DOI
- 10.2174/092986708783955545
- ISSN
- 0929-8673
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Curr Med Chem
- Schlüsselwörter
- Animals
- Cell Membrane
- Humans
- Protein Conformation
- Viral Matrix Proteins
- Viruses
- Sprache
- eng
- Country
- United Arab Emirates
- Paginierung
- 779 - 785
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2008
- Titel
- Lessons from viruses: controlling the function of transmembrane proteins by interfering transmembrane helices.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
- Ausgabe der Zeitschrift
- 15
Datenquelle: PubMed
- Beziehungen:
- Eigentum von