tRNA Stabilization by Modified Nucleotides

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Yuri Motorin
  • Mark Helm
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000278684400002&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1021/bi100408z
Externe Identifier
  • Clarivate Analytics Document Solution ID: 609VA
  • PubMed Identifier: 20459084
ISSN
0006-2960
Ausgabe der Veröffentlichung
24
Zeitschrift
BIOCHEMISTRY
Paginierung
4934 - 4944
Datum der Veröffentlichung
2010
Status
Published
Titel
tRNA Stabilization by Modified Nucleotides
Sub types
  • Article
Ausgabe der Zeitschrift
49

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Yuri Motorin
  • Mark Helm
DOI
10.1021/bi100408z
eISSN
1520-4995
ISSN
0006-2960
Ausgabe der Veröffentlichung
24
Zeitschrift
Biochemistry
Sprache
en
Online publication date
2010
Paginierung
4934 - 4944
Datum der Veröffentlichung
2010
Status
Published
Herausgeber
American Chemical Society (ACS)
Herausgeber URL
http://dx.doi.org/10.1021/bi100408z
Datum der Datenerfassung
2023
Titel
tRNA Stabilization by Modified Nucleotides
Ausgabe der Zeitschrift
49

Datenquelle: Crossref

Abstract
Post-transcriptional ribonucleotide modification is a phenomenon best studied in tRNA, where it occurs most frequently and in great chemical diversity. This paper reviews the intrinsic network of modifications in the structural core of the tRNA, which governs structural flexibility and rigidity to fine-tune the molecule to peak performance and to regulate its steady-state level. Structural effects of RNA modifications range from nanometer-scale rearrangements to subtle restrictions of conformational space on the angstrom scale. Structural stabilization resulting from nucleotide modification results in increased thermal stability and translates into protection against unspecific degradation by bases and nucleases. Several mechanisms of specific degradation of hypomodified tRNA, which were only recently discovered, provide a link between structural and metabolic stability.
Addresses
  • Laboratoire ARN-RNP Maturation-Structure-Fonction, Enzymologie Moléculaire et Structurale (AREMS), UMR 7214 CNRS-UHP Faculté des Sciences et Techniques, Université Henri Poincaré, Nancy 1, Bld des Aiguillettes, BP 70239, 54506 Vandoeuvre-les-Nancy, France.
Autoren
  • Yuri Motorin
  • Mark Helm
DOI
10.1021/bi100408z
eISSN
1520-4995
Externe Identifier
  • PubMed Identifier: 20459084
Open access
false
ISSN
0006-2960
Ausgabe der Veröffentlichung
24
Zeitschrift
Biochemistry
Schlüsselwörter
  • Animals
  • Humans
  • Nucleotides
  • RNA, Transfer
  • RNA Processing, Post-Transcriptional
  • Nucleic Acid Conformation
  • RNA Stability
  • Models, Molecular
Sprache
eng
Medium
Print
Paginierung
4934 - 4944
Datum der Veröffentlichung
2010
Status
Published
Datum der Datenerfassung
2010
Titel
tRNA stabilization by modified nucleotides.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
49

Datenquelle: Europe PubMed Central

Abstract
Post-transcriptional ribonucleotide modification is a phenomenon best studied in tRNA, where it occurs most frequently and in great chemical diversity. This paper reviews the intrinsic network of modifications in the structural core of the tRNA, which governs structural flexibility and rigidity to fine-tune the molecule to peak performance and to regulate its steady-state level. Structural effects of RNA modifications range from nanometer-scale rearrangements to subtle restrictions of conformational space on the angstrom scale. Structural stabilization resulting from nucleotide modification results in increased thermal stability and translates into protection against unspecific degradation by bases and nucleases. Several mechanisms of specific degradation of hypomodified tRNA, which were only recently discovered, provide a link between structural and metabolic stability.
Autoren
  • Yuri Motorin
  • Mark Helm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/20459084
DOI
10.1021/bi100408z
eISSN
1520-4995
Ausgabe der Veröffentlichung
24
Zeitschrift
Biochemistry
Schlüsselwörter
  • Animals
  • Humans
  • Models, Molecular
  • Nucleic Acid Conformation
  • Nucleotides
  • RNA Processing, Post-Transcriptional
  • RNA Stability
  • RNA, Transfer
Sprache
eng
Country
United States
Paginierung
4934 - 4944
Datum der Veröffentlichung
2010
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2010
Titel
tRNA stabilization by modified nucleotides.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
49

Datenquelle: PubMed

Beziehungen:
Eigentum von

Werkzeuge