A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Salifu Seidu-Larry
- Bettina Krieg
- Markus Hirsch
- Mark Helm
- Olwen Domingo
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000309840400024&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1039/c2cc34015a
- Externe Identifier
- Clarivate Analytics Document Solution ID: 020UP
- PubMed Identifier: 23037931
- ISSN
- 1359-7345
- Ausgabe der Veröffentlichung
- 89
- Zeitschrift
- CHEMICAL COMMUNICATIONS
- Paginierung
- 11014 - 11016
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge
- Sub types
- Article
- Ausgabe der Zeitschrift
- 48
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Salifu Seidu-Larry
- Bettina Krieg
- Markus Hirsch
- Mark Helm
- Olwen Domingo
- DOI
- 10.1039/c2cc34015a
- eISSN
- 1364-548X
- ISSN
- 1359-7345
- Ausgabe der Veröffentlichung
- 89
- Zeitschrift
- Chemical Communications
- Sprache
- en
- Paginierung
- 11014 - 11014
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Herausgeber
- Royal Society of Chemistry (RSC)
- Herausgeber URL
- http://dx.doi.org/10.1039/c2cc34015a
- Datum der Datenerfassung
- 2024
- Titel
- A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge
- Ausgabe der Zeitschrift
- 48
Datenquelle: Crossref
- Abstract
- A propargyl containing guanosine phosphoramidite was synthesized and incorporated into siRNA, enabling click-ligation with an azido fluorophore onto the nucleobase sugar edge. Duplex stability was not affected by labeling at this new site, which allowed deconvolution of the effects of label, structure and attachment site on RNAi activity.
- Addresses
- Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, 5 Staudinger Weg, Mainz, D-55128, Germany.
- Autoren
- Salifu Seidu-Larry
- Bettina Krieg
- Markus Hirsch
- Mark Helm
- Olwen Domingo
- DOI
- 10.1039/c2cc34015a
- eISSN
- 1364-548X
- Externe Identifier
- PubMed Identifier: 23037931
- Open access
- false
- ISSN
- 1359-7345
- Ausgabe der Veröffentlichung
- 89
- Zeitschrift
- Chemical communications (Cambridge, England)
- Schlüsselwörter
- Organophosphorus Compounds
- Carbohydrates
- RNA, Small Interfering
- RNA
- Guanosine
- Molecular Structure
- Click Chemistry
- Sprache
- eng
- Medium
- Paginierung
- 11014 - 11016
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum der Datenerfassung
- 2012
- Titel
- A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 48
Datenquelle: Europe PubMed Central
- Abstract
- A propargyl containing guanosine phosphoramidite was synthesized and incorporated into siRNA, enabling click-ligation with an azido fluorophore onto the nucleobase sugar edge. Duplex stability was not affected by labeling at this new site, which allowed deconvolution of the effects of label, structure and attachment site on RNAi activity.
- Autoren
- Salifu Seidu-Larry
- Bettina Krieg
- Markus Hirsch
- Mark Helm
- Olwen Domingo
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/23037931
- DOI
- 10.1039/c2cc34015a
- eISSN
- 1364-548X
- Ausgabe der Veröffentlichung
- 89
- Zeitschrift
- Chem Commun (Camb)
- Schlüsselwörter
- Carbohydrates
- Click Chemistry
- Guanosine
- Molecular Structure
- Organophosphorus Compounds
- RNA
- RNA, Small Interfering
- Sprache
- eng
- Country
- England
- Paginierung
- 11014 - 11016
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2013
- Titel
- A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 48
Datenquelle: PubMed
- Beziehungen:
- Eigentum von