RNA mediated Toll-like receptor stimulation in health and disease

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Alexander H Dalpke
  • Mark Helm
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000307077500013&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.4161/rna.20206
eISSN
1555-8584
Externe Identifier
  • Clarivate Analytics Document Solution ID: 982XA
  • PubMed Identifier: 22617878
ISSN
1547-6286
Ausgabe der Veröffentlichung
6
Zeitschrift
RNA BIOLOGY
Schlüsselwörter
  • Toll-like receptor
  • Innate Immunity
  • Nucleic acids
  • autoimmunity
  • infections
  • modifications
Paginierung
828 - 842
Datum der Veröffentlichung
2012
Status
Published
Titel
RNA mediated Toll-like receptor stimulation in health and disease
Sub types
  • Review
Ausgabe der Zeitschrift
9

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Alexander H Dalpke
  • Mark Helm
DOI
10.4161/rna.20206
eISSN
1555-8584
ISSN
1547-6286
Ausgabe der Veröffentlichung
6
Zeitschrift
RNA Biology
Sprache
en
Online publication date
2014
Paginierung
828 - 842
Datum der Veröffentlichung
2012
Status
Published
Herausgeber
Informa UK Limited
Herausgeber URL
http://dx.doi.org/10.4161/rna.20206
Datum der Datenerfassung
2017
Titel
RNA mediated toll-like receptor stimulation in health and disease
Ausgabe der Zeitschrift
9

Datenquelle: Crossref

Abstract
Besides their well known functions in storage and translation of information nucleic acids have emerged as a target of pattern recognition receptors that drive activation of innate immunity. Due to the paucity of building block monomers used in nucleic acids, discrimination of host and microbial nucleic acids as a means of self/foreign discrimination is a complicated task. Pattern recognition receptors rely on discrimination by sequence, structural features and spatial compartmentalization to differentiate microbial derived nucleic acids from host ones. Microbial nucleic acid detection is important for the sensing of infectious danger and initiating an immune response to microbial attack. Failures in the underlying recognitions systems can have severe consequences: thus, inefficient recognition of microbial nucleic acids may increase susceptibility to infectious diseases. On the other hand, excessive immune responses as a result of failed self/foreign discrimination are associated with autoimmune diseases. This review gives a general overview over the underlying concepts of nucleic acid sensing by Toll-like receptors. Within this general framework, we focus on bacterial RNA and synthetic RNA oligomers.
Addresses
  • Heidelberg University, Department of Infectious Diseases - Medical Microbiology and Hygiene, Im Neuenheimer Feld 324, Heidelberg 69120, Germany.
Autoren
  • Alexander Dalpke
  • Mark Helm
DOI
10.4161/rna.20206
eISSN
1555-8584
Externe Identifier
  • PubMed Identifier: 22617878
  • PubMed Central ID: PMC3495747
Open access
true
ISSN
1547-6286
Ausgabe der Veröffentlichung
6
Zeitschrift
RNA biology
Schlüsselwörter
  • Animals
  • Humans
  • Bacteria
  • Bacterial Infections
  • Autoimmune Diseases
  • RNA, Small Interfering
  • DNA, Bacterial
  • RNA, Bacterial
  • Base Sequence
  • Nucleic Acid Conformation
  • Protein Binding
  • Toll-Like Receptors
  • Immunity, Innate
Sprache
eng
Medium
Print-Electronic
Online publication date
2012
Open access status
Open Access
Paginierung
828 - 842
Datum der Veröffentlichung
2012
Status
Published
Publisher licence
CC BY-NC
Datum der Datenerfassung
2012
Titel
RNA mediated Toll-like receptor stimulation in health and disease.
Sub types
  • Research Support, Non-U.S. Gov't
  • review-article
  • Review
  • Journal Article
Ausgabe der Zeitschrift
9

Files

https://www.tandfonline.com/doi/pdf/10.4161/rna.20206?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22617878/pdf/?tool=EBI https://europepmc.org/articles/PMC3495747?pdf=render

Datenquelle: Europe PubMed Central

Abstract
Besides their well known functions in storage and translation of information nucleic acids have emerged as a target of pattern recognition receptors that drive activation of innate immunity. Due to the paucity of building block monomers used in nucleic acids, discrimination of host and microbial nucleic acids as a means of self/foreign discrimination is a complicated task. Pattern recognition receptors rely on discrimination by sequence, structural features and spatial compartmentalization to differentiate microbial derived nucleic acids from host ones. Microbial nucleic acid detection is important for the sensing of infectious danger and initiating an immune response to microbial attack. Failures in the underlying recognitions systems can have severe consequences: thus, inefficient recognition of microbial nucleic acids may increase susceptibility to infectious diseases. On the other hand, excessive immune responses as a result of failed self/foreign discrimination are associated with autoimmune diseases. This review gives a general overview over the underlying concepts of nucleic acid sensing by Toll-like receptors. Within this general framework, we focus on bacterial RNA and synthetic RNA oligomers.
Autoren
  • Alexander Dalpke
  • Mark Helm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/22617878
DOI
10.4161/rna.20206
eISSN
1555-8584
Externe Identifier
  • PubMed Central ID: PMC3495747
Ausgabe der Veröffentlichung
6
Zeitschrift
RNA Biol
Schlüsselwörter
  • Animals
  • Autoimmune Diseases
  • Bacteria
  • Bacterial Infections
  • Base Sequence
  • DNA, Bacterial
  • Humans
  • Immunity, Innate
  • Nucleic Acid Conformation
  • Protein Binding
  • RNA, Bacterial
  • RNA, Small Interfering
  • Toll-Like Receptors
Sprache
eng
Country
United States
Paginierung
828 - 842
PII
20206
Datum der Veröffentlichung
2012
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2013
Titel
RNA mediated Toll-like receptor stimulation in health and disease.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
9

Datenquelle: PubMed

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