DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position

Publikationstyp:
Kapitel
Metadaten:
Autoren
  • Yuri Motorin
  • Salifu Seidu-Larry
  • Mark Helm
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000400691000003&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1007/978-3-319-43624-1_2
ISBN-13
978-3-319-43622-7
Paginierung
19 - 33
Buchtitel
DNA METHYLTRANSFERASES - ROLE AND FUNCTION
Datum der Veröffentlichung
2016
Status
Published
Titel
DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position
Ausgabe der Zeitschrift
945

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Yuri Motorin
  • Salifu Seidu-Larry
  • Mark Helm
DOI
10.1007/978-3-319-43624-1_2
ISBN-13
9783319436227
Online publication date
2016
Paginierung
19 - 33
Buchtitel
Advances in Experimental Medicine and Biology
Datum der Veröffentlichung
2016
Status
Published
Herausgeber
Springer International Publishing
Herausgeber URL
http://dx.doi.org/10.1007/978-3-319-43624-1_2
Datum der Datenerfassung
2022
Titel
DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position

Datenquelle: Crossref

Abstract
The carbon 5 of pyrimidine nucleobases is a privileged position in terms of nucleoside modification in both DNA and RNA. The simplest modification of uridine at this position is methylation leading to thymine. Thymine is an integral part of the standard nucleobase repertoire of DNA that is synthesized at the nucleotide level. However, it also occurs in RNA, where it is synthesized posttranscriptionally at the polynucleotide level. The cytidine analogue 5-methylcytidine also occurs in both DNA and RNA, but is introduced at the polynucleotide level in both cases. The same applies to a plethora of additional derivatives found in nature, resulting either from a direct modification of the 5-position by electrophiles or by further derivatization of the 5-methylpyrimidines. Here, we review the structural diversity of these modified bases, the variety of cofactors that serve as carbon donors, and the common principles shared by enzymatic mechanisms generating them.
Addresses
  • IMoPA UMR7365 CNRS-UL, BioPole de l'Université de Lorraine, 9 avenue de la Foret de Haye, 54505, Vandoeuvre-les-Nancy, France. motorine5@univ-lorraine.fr.
Autoren
  • Yuri Motorin
  • Salifu Seidu-Larry
  • Mark Helm
DOI
10.1007/978-3-319-43624-1_2
Open access
false
Schlüsselwörter
  • Carbon
  • Thymidylate Synthase
  • DNA
  • RNA
  • Pyrimidine Nucleosides
  • Cytidine
  • Uridine
  • DNA Methylation
  • Molecular Structure
  • Alkylation
Medium
Print
Paginierung
19 - 33
Datum der Veröffentlichung
2016
Status
Published
Datum der Datenerfassung
2016
Titel
DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position.
Ausgabe der Zeitschrift
945

Datenquelle: Europe PubMed Central

Abstract
The carbon 5 of pyrimidine nucleobases is a privileged position in terms of nucleoside modification in both DNA and RNA. The simplest modification of uridine at this position is methylation leading to thymine. Thymine is an integral part of the standard nucleobase repertoire of DNA that is synthesized at the nucleotide level. However, it also occurs in RNA, where it is synthesized posttranscriptionally at the polynucleotide level. The cytidine analogue 5-methylcytidine also occurs in both DNA and RNA, but is introduced at the polynucleotide level in both cases. The same applies to a plethora of additional derivatives found in nature, resulting either from a direct modification of the 5-position by electrophiles or by further derivatization of the 5-methylpyrimidines. Here, we review the structural diversity of these modified bases, the variety of cofactors that serve as carbon donors, and the common principles shared by enzymatic mechanisms generating them.
Autoren
  • Yuri Motorin
  • Salifu Seidu-Larry
  • Mark Helm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/27826833
DOI
10.1007/978-3-319-43624-1_2
Schlüsselwörter
  • Alkylation
  • Carbon
  • Cytidine
  • DNA
  • DNA Methylation
  • Molecular Structure
  • Pyrimidine Nucleosides
  • RNA
  • Thymidylate Synthase
  • Uridine
Paginierung
19 - 33
Datum der Veröffentlichung
2016
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2017
Titel
DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position.
Ausgabe der Zeitschrift
945

Datenquelle: PubMed

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