m6A modulates neuronal functions and sex determination in Drosophila
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Tina Lence
- Junaid Akhtar
- Marc Bayer
- Katharina Schmid
- Laura Spindler
- Cheuk Hei Ho
- Nastasja Kreim
- Miguel A Andrade-Navarro
- Burkhard Poeck
- Mark Helm
- Jean-Yves Roignant
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000389548700051&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1038/nature20568
- eISSN
- 1476-4687
- Externe Identifier
- Clarivate Analytics Document Solution ID: EE4CF
- PubMed Identifier: 27919077
- ISSN
- 0028-0836
- Ausgabe der Veröffentlichung
- 7632
- Zeitschrift
- NATURE
- Paginierung
- 242 - +
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- m<SUP>6</SUP>A modulates neuronal functions and sex determination in <i>Drosophila</i>
- Sub types
- Article
- Ausgabe der Zeitschrift
- 540
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Tina Lence
- Junaid Akhtar
- Marc Bayer
- Katharina Schmid
- Laura Spindler
- Cheuk Hei Ho
- Nastasja Kreim
- Miguel A Andrade-Navarro
- Burkhard Poeck
- Mark Helm
- Jean-Yves Roignant
- DOI
- 10.1038/nature20568
- eISSN
- 1476-4687
- ISSN
- 0028-0836
- Ausgabe der Veröffentlichung
- 7632
- Zeitschrift
- Nature
- Sprache
- en
- Online publication date
- 2016
- Paginierung
- 242 - 247
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/nature20568
- Datum der Datenerfassung
- 2023
- Titel
- m6A modulates neuronal functions and sex determination in Drosophila
- Ausgabe der Zeitschrift
- 540
Datenquelle: Crossref
- Abstract
- N<sup>6</sup>-methyladenosine RNA (m<sup>6</sup>A) is a prevalent messenger RNA modification in vertebrates. Although its functions in the regulation of post-transcriptional gene expression are beginning to be unveiled, the precise roles of m<sup>6</sup>A during development of complex organisms remain unclear. Here we carry out a comprehensive molecular and physiological characterization of the individual components of the methyltransferase complex, as well as of the YTH domain-containing nuclear reader protein in Drosophila melanogaster. We identify the member of the split ends protein family, Spenito, as a novel bona fide subunit of the methyltransferase complex. We further demonstrate important roles of this complex in neuronal functions and sex determination, and implicate the nuclear YT521-B protein as a main m<sup>6</sup>A effector in these processes. Altogether, our work substantially extends our knowledge of m<sup>6</sup>A biology, demonstrating the crucial functions of this modification in fundamental processes within the context of the whole animal.
- Addresses
- Institute of Molecular Biology (IMB), 55128 Mainz, Germany.
- Autoren
- Tina Lence
- Junaid Akhtar
- Marc Bayer
- Katharina Schmid
- Laura Spindler
- Cheuk Hei Ho
- Nastasja Kreim
- Miguel A Andrade-Navarro
- Burkhard Poeck
- Mark Helm
- Jean-Yves Roignant
- DOI
- 10.1038/nature20568
- eISSN
- 1476-4687
- Externe Identifier
- PubMed Identifier: 27919077
- Open access
- false
- ISSN
- 0028-0836
- Ausgabe der Veröffentlichung
- 7632
- Zeitschrift
- Nature
- Schlüsselwörter
- Nervous System
- Neurons
- Animals
- Drosophila melanogaster
- Methyltransferases
- RNA-Binding Proteins
- Drosophila Proteins
- Nuclear Proteins
- Protein Subunits
- Adenosine
- Behavior, Animal
- Alternative Splicing
- Phenotype
- Female
- Male
- Sex Determination Processes
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2016
- Paginierung
- 242 - 247
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum der Datenerfassung
- 2016
- Titel
- m<sup>6</sup>A modulates neuronal functions and sex determination in Drosophila.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 540
Datenquelle: Europe PubMed Central
- Abstract
- N6-methyladenosine RNA (m6A) is a prevalent messenger RNA modification in vertebrates. Although its functions in the regulation of post-transcriptional gene expression are beginning to be unveiled, the precise roles of m6A during development of complex organisms remain unclear. Here we carry out a comprehensive molecular and physiological characterization of the individual components of the methyltransferase complex, as well as of the YTH domain-containing nuclear reader protein in Drosophila melanogaster. We identify the member of the split ends protein family, Spenito, as a novel bona fide subunit of the methyltransferase complex. We further demonstrate important roles of this complex in neuronal functions and sex determination, and implicate the nuclear YT521-B protein as a main m6A effector in these processes. Altogether, our work substantially extends our knowledge of m6A biology, demonstrating the crucial functions of this modification in fundamental processes within the context of the whole animal.
- Date of acceptance
- 2016
- Autoren
- Tina Lence
- Junaid Akhtar
- Marc Bayer
- Katharina Schmid
- Laura Spindler
- Cheuk Hei Ho
- Nastasja Kreim
- Miguel A Andrade-Navarro
- Burkhard Poeck
- Mark Helm
- Jean-Yves Roignant
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/27919077
- DOI
- 10.1038/nature20568
- eISSN
- 1476-4687
- Ausgabe der Veröffentlichung
- 7632
- Zeitschrift
- Nature
- Schlüsselwörter
- Adenosine
- Alternative Splicing
- Animals
- Behavior, Animal
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Male
- Methyltransferases
- Nervous System
- Neurons
- Nuclear Proteins
- Phenotype
- Protein Subunits
- RNA-Binding Proteins
- Sex Determination Processes
- Sprache
- eng
- Country
- England
- Paginierung
- 242 - 247
- PII
- nature20568
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2017
- Titel
- m6A modulates neuronal functions and sex determination in Drosophila.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 540
Datenquelle: PubMed
- Beziehungen:
- Eigentum von