RNA Modifications Modulate Activation of Innate Toll-Like Receptors
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Isabel Freund
- Tatjana Eigenbrod
- Mark Helm
- Alexander H Dalpke
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000460742800021&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/genes10020092
- Externe Identifier
- Clarivate Analytics Document Solution ID: HO2KE
- PubMed Identifier: 30699960
- ISSN
- 2073-4425
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- GENES
- Schlüsselwörter
- innate immunity
- methylation
- RNA modifications
- Toll-like receptors
- Artikelnummer
- ARTN 92
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Titel
- RNA Modifications Modulate Activation of Innate Toll-Like Receptors
- Sub types
- Review
- Ausgabe der Zeitschrift
- 10
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>Self/foreign discrimination by the innate immune system depends on receptors that identify molecular patterns as associated to pathogens. Among others, this group includes endosomal Toll-like receptors, among which Toll-like receptors (TLR) 3, 7, 8, and 13 recognize and discriminate mammalian from microbial, potentially pathogen-associated, RNA. One of the discriminatory principles is the recognition of endogenous RNA modifications. Previous work has identified a couple of RNA modifications that impede activation of TLR signaling when incorporated in synthetic RNA molecules. Of note, work that is more recent has now shown that RNA modifications in their naturally occurring context can have immune-modulatory functions: Gm, a naturally occurring ribose-methylation within tRNA resulted in a lack of TLR7 stimulation and within a defined sequence context acted as antagonist. Additional RNA modifications with immune-modulatory functions have now been identified and recent work also indicates that RNA modifications within the context of whole prokaryotic or eukaryotic cells are indeed used for immune-modulation. This review will discuss new findings and developments in the field of immune-modulatory RNA modifications.</jats:p>
- Autoren
- Isabel Freund
- Tatjana Eigenbrod
- Mark Helm
- Alexander Dalpke
- DOI
- 10.3390/genes10020092
- eISSN
- 2073-4425
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Genes
- Sprache
- en
- Online publication date
- 2019
- Paginierung
- 92 - 92
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/genes10020092
- Datum der Datenerfassung
- 2019
- Titel
- RNA Modifications Modulate Activation of Innate Toll-Like Receptors
- Ausgabe der Zeitschrift
- 10
Datenquelle: Crossref
- Abstract
- Self/foreign discrimination by the innate immune system depends on receptors that identify molecular patterns as associated to pathogens. Among others, this group includes endosomal Toll-like receptors, among which Toll-like receptors (TLR) 3, 7, 8, and 13 recognize and discriminate mammalian from microbial, potentially pathogen-associated, RNA. One of the discriminatory principles is the recognition of endogenous RNA modifications. Previous work has identified a couple of RNA modifications that impede activation of TLR signaling when incorporated in synthetic RNA molecules. Of note, work that is more recent has now shown that RNA modifications in their naturally occurring context can have immune-modulatory functions: Gm, a naturally occurring ribose-methylation within tRNA resulted in a lack of TLR7 stimulation and within a defined sequence context acted as antagonist. Additional RNA modifications with immune-modulatory functions have now been identified and recent work also indicates that RNA modifications within the context of whole prokaryotic or eukaryotic cells are indeed used for immune-modulation. This review will discuss new findings and developments in the field of immune-modulatory RNA modifications.
- Addresses
- Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany. isabel-freund@t-online.de.
- Autoren
- Isabel Freund
- Tatjana Eigenbrod
- Mark Helm
- Alexander H Dalpke
- DOI
- 10.3390/genes10020092
- eISSN
- 2073-4425
- Externe Identifier
- PubMed Identifier: 30699960
- PubMed Central ID: PMC6410116
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft: DA592/5, DA592/7
- Open access
- true
- ISSN
- 2073-4425
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Genes
- Schlüsselwörter
- Animals
- Humans
- RNA Processing, Post-Transcriptional
- Toll-Like Receptors
- Immunity, Innate
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2019
- Open access status
- Open Access
- Paginierung
- E92
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2019
- Titel
- RNA Modifications Modulate Activation of Innate Toll-Like Receptors.
- Sub types
- Research Support, Non-U.S. Gov't
- review-article
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 10
Files
https://www.mdpi.com/2073-4425/10/2/92/pdf?version=1548755721 https://europepmc.org/articles/PMC6410116?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Self/foreign discrimination by the innate immune system depends on receptors that identify molecular patterns as associated to pathogens. Among others, this group includes endosomal Toll-like receptors, among which Toll-like receptors (TLR) 3, 7, 8, and 13 recognize and discriminate mammalian from microbial, potentially pathogen-associated, RNA. One of the discriminatory principles is the recognition of endogenous RNA modifications. Previous work has identified a couple of RNA modifications that impede activation of TLR signaling when incorporated in synthetic RNA molecules. Of note, work that is more recent has now shown that RNA modifications in their naturally occurring context can have immune-modulatory functions: Gm, a naturally occurring ribose-methylation within tRNA resulted in a lack of TLR7 stimulation and within a defined sequence context acted as antagonist. Additional RNA modifications with immune-modulatory functions have now been identified and recent work also indicates that RNA modifications within the context of whole prokaryotic or eukaryotic cells are indeed used for immune-modulation. This review will discuss new findings and developments in the field of immune-modulatory RNA modifications.
- Date of acceptance
- 2019
- Autoren
- Isabel Freund
- Tatjana Eigenbrod
- Mark Helm
- Alexander H Dalpke
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/30699960
- DOI
- 10.3390/genes10020092
- Externe Identifier
- PubMed Central ID: PMC6410116
- ISSN
- 2073-4425
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Genes (Basel)
- Schlüsselwörter
- RNA modifications
- Toll-like receptors
- innate immunity
- methylation
- Animals
- Humans
- Immunity, Innate
- RNA Processing, Post-Transcriptional
- Toll-Like Receptors
- Sprache
- eng
- Country
- Switzerland
- PII
- genes10020092
- Datum der Veröffentlichung
- 2019
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2019
- Titel
- RNA Modifications Modulate Activation of Innate Toll-Like Receptors.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
- Ausgabe der Zeitschrift
- 10
Datenquelle: PubMed
- Beziehungen:
- Eigentum von