Detecting RNA modifications in the epitranscriptome: predict and validate
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Mark Helm
- Yuri Motorin
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000398894200009&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1038/nrg.2016.169
- eISSN
- 1471-0064
- Externe Identifier
- Clarivate Analytics Document Solution ID: ER6DD
- PubMed Identifier: 28216634
- ISSN
- 1471-0056
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- NATURE REVIEWS GENETICS
- Paginierung
- 275 - 291
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Titel
- Detecting RNA modifications in the epitranscriptome: predict and validate
- Sub types
- Review
- Ausgabe der Zeitschrift
- 18
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Mark Helm
- Yuri Motorin
- DOI
- 10.1038/nrg.2016.169
- eISSN
- 1471-0064
- ISSN
- 1471-0056
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Nature Reviews Genetics
- Sprache
- en
- Online publication date
- 2017
- Paginierung
- 275 - 291
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/nrg.2016.169
- Datum der Datenerfassung
- 2023
- Titel
- Detecting RNA modifications in the epitranscriptome: predict and validate
- Ausgabe der Zeitschrift
- 18
Datenquelle: Crossref
- Abstract
- RNA modifications are emerging players in the field of post-transcriptional regulation of gene expression, and are attracting a comparable degree of research interest to DNA and histone modifications in the field of epigenetics. We now know of more than 150 RNA modifications and the true potential of a few of these is currently emerging as the consequence of a leap in detection technology, principally associated with high-throughput sequencing. This Review outlines the major developments in this field through a structured discussion of detection principles, lays out advantages and drawbacks of new high-throughput methods and presents conventional biophysical identification of modifications as meaningful ways for validation.
- Addresses
- Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.
- Autoren
- Mark Helm
- Yuri Motorin
- DOI
- 10.1038/nrg.2016.169
- eISSN
- 1471-0064
- Externe Identifier
- PubMed Identifier: 28216634
- Open access
- false
- ISSN
- 1471-0056
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Nature reviews. Genetics
- Schlüsselwörter
- Animals
- Humans
- RNA
- Gene Expression Regulation
- Epigenesis, Genetic
- RNA Processing, Post-Transcriptional
- Epigenomics
- Transcriptome
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2017
- Paginierung
- 275 - 291
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Datum der Datenerfassung
- 2017
- Titel
- Detecting RNA modifications in the epitranscriptome: predict and validate.
- Sub types
- Research Support, Non-U.S. Gov't
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 18
Datenquelle: Europe PubMed Central
- Abstract
- RNA modifications are emerging players in the field of post-transcriptional regulation of gene expression, and are attracting a comparable degree of research interest to DNA and histone modifications in the field of epigenetics. We now know of more than 150 RNA modifications and the true potential of a few of these is currently emerging as the consequence of a leap in detection technology, principally associated with high-throughput sequencing. This Review outlines the major developments in this field through a structured discussion of detection principles, lays out advantages and drawbacks of new high-throughput methods and presents conventional biophysical identification of modifications as meaningful ways for validation.
- Autoren
- Mark Helm
- Yuri Motorin
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/28216634
- DOI
- 10.1038/nrg.2016.169
- eISSN
- 1471-0064
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Nat Rev Genet
- Schlüsselwörter
- Animals
- Epigenesis, Genetic
- Epigenomics
- Gene Expression Regulation
- Humans
- RNA
- RNA Processing, Post-Transcriptional
- Transcriptome
- Sprache
- eng
- Country
- England
- Paginierung
- 275 - 291
- PII
- nrg.2016.169
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2017
- Titel
- Detecting RNA modifications in the epitranscriptome: predict and validate.
- Sub types
- Journal Article
- Review
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 18
Datenquelle: PubMed
- Beziehungen:
- Eigentum von