An epigenetic 'extreme makeover': the methylation of flaviviral RNA (and beyond)
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Alessia Ruggieri
- Mark Helm
- Laurent Chatel-Chaix
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000608342100001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1080/15476286.2020.1868150
- eISSN
- 1555-8584
- Externe Identifier
- Clarivate Analytics Document Solution ID: RQ1OE
- PubMed Identifier: 33356825
- ISSN
- 1547-6286
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- RNA BIOLOGY
- Schlüsselwörter
- Flavivirus
- viral RNA
- RNA modification
- RNA methylation
- (N6)-methyladenosine
- 2 '-O-methylation
- cap
- dengue virus
- Zika virus
- West Nile virus
- Paginierung
- 696 - 708
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- An epigenetic 'extreme makeover': the methylation of flaviviral RNA (and beyond)
- Sub types
- Review
- Ausgabe der Zeitschrift
- 18
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Alessia Ruggieri
- Mark Helm
- Laurent Chatel-Chaix
- DOI
- 10.1080/15476286.2020.1868150
- eISSN
- 1555-8584
- ISSN
- 1547-6286
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- RNA Biology
- Sprache
- en
- Online publication date
- 2021
- Paginierung
- 696 - 708
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- Informa UK Limited
- Herausgeber URL
- http://dx.doi.org/10.1080/15476286.2020.1868150
- Datum der Datenerfassung
- 2022
- Titel
- An epigenetic ‘extreme makeover’: the methylation of flaviviral RNA (and beyond)
- Ausgabe der Zeitschrift
- 18
Datenquelle: Crossref
- Abstract
- Beyond their high clinical relevance worldwide, flaviviruses (comprising dengue and Zika viruses) are of particular interest to understand the spatiotemporal control of RNA metabolism. Indeed, their positive single-stranded viral RNA genome (vRNA) undergoes in the cytoplasm replication, translation and encapsidation, three steps of the flavivirus life cycle that are coordinated through a fine-tuned equilibrium. Over the last years, RNA methylation has emerged as a powerful mechanism to regulate messenger RNA metabolism at the posttranscriptional level. Not surprisingly, flaviviruses exploit RNA epigenetic strategies to control crucial steps of their replication cycle as well as to evade sensing by the innate immune system. This review summarizes the current knowledge about vRNA methylation events and their impacts on flavivirus replication and pathogenesis. We also address the important challenges that the field of epitranscriptomics faces in reliably and accurately identifying RNA methylation sites, which should be considered in future studies on viral RNA modifications.
- Addresses
- Department of Infectious Diseases, Molecular Virology, Centre for Integrative Infectious Disease Research University of Heidelberg, Heidelberg, Germany.
- Autoren
- Alessia Ruggieri
- Mark Helm
- Laurent Chatel-Chaix
- DOI
- 10.1080/15476286.2020.1868150
- eISSN
- 1555-8584
- Externe Identifier
- PubMed Identifier: 33356825
- PubMed Central ID: PMC8078509
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft:
- Fonds de Recherche du Québec - Santé:
- Fonds de Recherche du Québec - Nature et Technologies: 2018-NC-205593
- Natural Sciences and Engineering Research Council of Canada: RGPIN-2016-05584
- Open access
- false
- ISSN
- 1547-6286
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- RNA biology
- Schlüsselwörter
- Animals
- Humans
- Flavivirus
- RNA, Viral
- Virus Replication
- Epigenesis, Genetic
- Methylation
- Genome, Viral
- Zika Virus
- Zika Virus Infection
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2021
- Paginierung
- 696 - 708
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum der Datenerfassung
- 2020
- Titel
- An epigenetic 'extreme makeover': the methylation of flaviviral RNA (and beyond).
- Sub types
- Research Support, Non-U.S. Gov't
- review-article
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 18
Files
https://www.tandfonline.com/doi/pdf/10.1080/15476286.2020.1868150?needAccess=true https://europepmc.org/articles/PMC8078509?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Beyond their high clinical relevance worldwide, flaviviruses (comprising dengue and Zika viruses) are of particular interest to understand the spatiotemporal control of RNA metabolism. Indeed, their positive single-stranded viral RNA genome (vRNA) undergoes in the cytoplasm replication, translation and encapsidation, three steps of the flavivirus life cycle that are coordinated through a fine-tuned equilibrium. Over the last years, RNA methylation has emerged as a powerful mechanism to regulate messenger RNA metabolism at the posttranscriptional level. Not surprisingly, flaviviruses exploit RNA epigenetic strategies to control crucial steps of their replication cycle as well as to evade sensing by the innate immune system. This review summarizes the current knowledge about vRNA methylation events and their impacts on flavivirus replication and pathogenesis. We also address the important challenges that the field of epitranscriptomics faces in reliably and accurately identifying RNA methylation sites, which should be considered in future studies on viral RNA modifications.
- Autoren
- Alessia Ruggieri
- Mark Helm
- Laurent Chatel-Chaix
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/33356825
- DOI
- 10.1080/15476286.2020.1868150
- eISSN
- 1555-8584
- Externe Identifier
- PubMed Central ID: PMC8078509
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- RNA Biol
- Schlüsselwörter
- 2ʹ-O-methylation
- Flavivirus
- N6-methyladenosine
- RNA methylation
- RNA modification
- West Nile virus
- Zika virus
- cap
- dengue virus
- viral RNA
- Animals
- Epigenesis, Genetic
- Flavivirus
- Genome, Viral
- Humans
- Methylation
- RNA, Viral
- Virus Replication
- Zika Virus
- Zika Virus Infection
- Sprache
- eng
- Country
- United States
- Paginierung
- 696 - 708
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- An epigenetic 'extreme makeover': the methylation of flaviviral RNA (and beyond).
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
- Ausgabe der Zeitschrift
- 18
Datenquelle: PubMed
- Beziehungen:
- Eigentum von