RNA modifications in physiology and disease: towards clinical applications
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Sylvain Delaunay
- Mark Helm
- Michaela Frye
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:001066757000002&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1038/s41576-023-00645-2
- eISSN
- 1471-0064
- Externe Identifier
- Clarivate Analytics Document Solution ID: FP9B0
- PubMed Identifier: 37714958
- ISSN
- 1471-0056
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- NATURE REVIEWS GENETICS
- Paginierung
- 104 - 122
- Datum der Veröffentlichung
- 2024
- Status
- Published
- Titel
- RNA modifications in physiology and disease: towards clinical applications
- Sub types
- Review
- Ausgabe der Zeitschrift
- 25
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Sylvain Delaunay
- Mark Helm
- Michaela Frye
- DOI
- 10.1038/s41576-023-00645-2
- eISSN
- 1471-0064
- ISSN
- 1471-0056
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Nature Reviews Genetics
- Sprache
- en
- Online publication date
- 2023
- Paginierung
- 104 - 122
- Datum der Veröffentlichung
- 2024
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/s41576-023-00645-2
- Datum der Datenerfassung
- 2024
- Titel
- RNA modifications in physiology and disease: towards clinical applications
- Ausgabe der Zeitschrift
- 25
Datenquelle: Crossref
- Abstract
- The ability of chemical modifications of single nucleotides to alter the electrostatic charge, hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of stable artificial RNAs such as mRNA vaccines and synthetic small RNA molecules - to increase or decrease the expression of therapeutic proteins. Furthermore, naturally occurring biochemical modifications of nucleotides regulate RNA metabolism and function to modulate crucial cellular processes. Studies showing the mechanisms by which RNA modifications regulate basic cell functions in higher organisms have led to greater understanding of how aberrant RNA modification profiles can cause disease in humans. Together, these basic science discoveries have unravelled the molecular and cellular functions of RNA modifications, have provided new prospects for therapeutic manipulation and have led to a range of innovative clinical approaches.
- Addresses
- Deutsches Krebsforschungszentrum (DKFZ), Division of Mechanisms Regulating Gene Expression, Heidelberg, Germany.
- Autoren
- Sylvain Delaunay
- Mark Helm
- Michaela Frye
- DOI
- 10.1038/s41576-023-00645-2
- eISSN
- 1471-0064
- Externe Identifier
- PubMed Identifier: 37714958
- Open access
- false
- ISSN
- 1471-0056
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Nature reviews. Genetics
- Schlüsselwörter
- Humans
- Nucleotides
- RNA
- RNA Processing, Post-Transcriptional
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2023
- Paginierung
- 104 - 122
- Datum der Veröffentlichung
- 2024
- Status
- Published
- Datum der Datenerfassung
- 2023
- Titel
- RNA modifications in physiology and disease: towards clinical applications.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 25
Datenquelle: Europe PubMed Central
- Abstract
- The ability of chemical modifications of single nucleotides to alter the electrostatic charge, hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of stable artificial RNAs such as mRNA vaccines and synthetic small RNA molecules - to increase or decrease the expression of therapeutic proteins. Furthermore, naturally occurring biochemical modifications of nucleotides regulate RNA metabolism and function to modulate crucial cellular processes. Studies showing the mechanisms by which RNA modifications regulate basic cell functions in higher organisms have led to greater understanding of how aberrant RNA modification profiles can cause disease in humans. Together, these basic science discoveries have unravelled the molecular and cellular functions of RNA modifications, have provided new prospects for therapeutic manipulation and have led to a range of innovative clinical approaches.
- Date of acceptance
- 2023
- Autoren
- Sylvain Delaunay
- Mark Helm
- Michaela Frye
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/37714958
- DOI
- 10.1038/s41576-023-00645-2
- eISSN
- 1471-0064
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Nat Rev Genet
- Schlüsselwörter
- Humans
- RNA
- Nucleotides
- RNA Processing, Post-Transcriptional
- Sprache
- eng
- Country
- England
- Paginierung
- 104 - 122
- PII
- 10.1038/s41576-023-00645-2
- Datum der Veröffentlichung
- 2024
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2024
- Titel
- RNA modifications in physiology and disease: towards clinical applications.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 25
Datenquelle: PubMed
- Beziehungen:
- Eigentum von