Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Mark Helm
- Markus T Bohnsack
- Thomas Carell
- Alexander Dalpke
- Karl-Dieter Entian
- Ann Ehrenhofer-Murray
- Ralf Ficner
- Christian Hammann
- Claudia Ho''bartner
- Andres Ja''schke
- Albert Jeltsch
- Stefanie Kaiser
- Roland Klassen
- Sebastian A Leidel
- Andreas Marx
- Mario Mo''rl
- Jochen C Meier
- Gunter Meister
- Andrea Rentmeister
- Marina Rodnina
- Jean-Yves Roignant
- Raffael Schaffrath
- Peter Stadler
- Thorsten Stafforst
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:001126747800001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1021/acschembio.3c00586
- eISSN
- 1554-8937
- Externe Identifier
- Clarivate Analytics Document Solution ID: CQ6L6
- PubMed Identifier: 37962075
- ISSN
- 1554-8929
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- ACS CHEMICAL BIOLOGY
- Paginierung
- 2441 - 2449
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Titel
- Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications
- Sub types
- Article
- Ausgabe der Zeitschrift
- 18
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Mark Helm
- Markus T Bohnsack
- Thomas Carell
- Alexander Dalpke
- Karl-Dieter Entian
- Ann Ehrenhofer-Murray
- Ralf Ficner
- Christian Hammann
- Claudia Höbartner
- Andres Jäschke
- Albert Jeltsch
- Stefanie Kaiser
- Roland Klassen
- Sebastian A Leidel
- Andreas Marx
- Mario Mörl
- Jochen C Meier
- Gunter Meister
- Andrea Rentmeister
- Marina Rodnina
- Jean-Yves Roignant
- Raffael Schaffrath
- Peter Stadler
- Thorsten Stafforst
- DOI
- 10.1021/acschembio.3c00586
- eISSN
- 1554-8937
- ISSN
- 1554-8929
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- ACS Chemical Biology
- Sprache
- en
- Online publication date
- 2023
- Paginierung
- 2441 - 2449
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Herausgeber
- American Chemical Society (ACS)
- Herausgeber URL
- http://dx.doi.org/10.1021/acschembio.3c00586
- Datum der Datenerfassung
- 2023
- Titel
- Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications
- Ausgabe der Zeitschrift
- 18
Datenquelle: Crossref
- Abstract
- The chemical biology of native nucleic acid modifications has seen an intense upswing, first concerning DNA modifications in the field of epigenetics and then concerning RNA modifications in a field that was correspondingly rebaptized epitranscriptomics by analogy. The German Research Foundation (DFG) has funded several consortia with a scientific focus in these fields, strengthening the traditionally well-developed nucleic acid chemistry community and inciting it to team up with colleagues from the life sciences and data science to tackle interdisciplinary challenges. This Perspective focuses on the genesis, scientific outcome, and downstream impact of the DFG priority program SPP1784 and offers insight into how it fecundated further consortia in the field. Pertinent research was funded from mid-2015 to 2022, including an extension related to the coronavirus pandemic. Despite being a detriment to research activity in general, the pandemic has resulted in tremendously boosted interest in the field of RNA and RNA modifications as a consequence of their widespread and successful use in vaccination campaigns against SARS-CoV-2. Funded principal investigators published over 250 pertinent papers with a very substantial impact on the field. The program also helped to redirect numerous laboratories toward this dynamic field. Finally, SPP1784 spawned initiatives for several funded consortia that continue to drive the fields of nucleic acid modification.
- Addresses
- Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.
- Autoren
- Mark Helm
- Markus T Bohnsack
- Thomas Carell
- Alexander Dalpke
- Karl-Dieter Entian
- Ann Ehrenhofer-Murray
- Ralf Ficner
- Christian Hammann
- Claudia Höbartner
- Andres Jäschke
- Albert Jeltsch
- Stefanie Kaiser
- Roland Klassen
- Sebastian A Leidel
- Andreas Marx
- Mario Mörl
- Jochen C Meier
- Gunter Meister
- Andrea Rentmeister
- Marina Rodnina
- Jean-Yves Roignant
- Raffael Schaffrath
- Peter Stadler
- Thorsten Stafforst
- DOI
- 10.1021/acschembio.3c00586
- eISSN
- 1554-8937
- Externe Identifier
- PubMed Identifier: 37962075
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft: TRR 319 RMaP (439669440)
- Open access
- false
- ISSN
- 1554-8929
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- ACS chemical biology
- Schlüsselwörter
- Nucleic Acids
- RNA
- Biology
- Epigenesis, Genetic
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2023
- Paginierung
- 2441 - 2449
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Datum der Datenerfassung
- 2023
- Titel
- Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 18
Datenquelle: Europe PubMed Central
- Abstract
- The chemical biology of native nucleic acid modifications has seen an intense upswing, first concerning DNA modifications in the field of epigenetics and then concerning RNA modifications in a field that was correspondingly rebaptized epitranscriptomics by analogy. The German Research Foundation (DFG) has funded several consortia with a scientific focus in these fields, strengthening the traditionally well-developed nucleic acid chemistry community and inciting it to team up with colleagues from the life sciences and data science to tackle interdisciplinary challenges. This Perspective focuses on the genesis, scientific outcome, and downstream impact of the DFG priority program SPP1784 and offers insight into how it fecundated further consortia in the field. Pertinent research was funded from mid-2015 to 2022, including an extension related to the coronavirus pandemic. Despite being a detriment to research activity in general, the pandemic has resulted in tremendously boosted interest in the field of RNA and RNA modifications as a consequence of their widespread and successful use in vaccination campaigns against SARS-CoV-2. Funded principal investigators published over 250 pertinent papers with a very substantial impact on the field. The program also helped to redirect numerous laboratories toward this dynamic field. Finally, SPP1784 spawned initiatives for several funded consortia that continue to drive the fields of nucleic acid modification.
- Autoren
- Mark Helm
- Markus T Bohnsack
- Thomas Carell
- Alexander Dalpke
- Karl-Dieter Entian
- Ann Ehrenhofer-Murray
- Ralf Ficner
- Christian Hammann
- Claudia Höbartner
- Andres Jäschke
- Albert Jeltsch
- Stefanie Kaiser
- Roland Klassen
- Sebastian A Leidel
- Andreas Marx
- Mario Mörl
- Jochen C Meier
- Gunter Meister
- Andrea Rentmeister
- Marina Rodnina
- Jean-Yves Roignant
- Raffael Schaffrath
- Peter Stadler
- Thorsten Stafforst
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/37962075
- DOI
- 10.1021/acschembio.3c00586
- eISSN
- 1554-8937
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- ACS Chem Biol
- Schlüsselwörter
- Nucleic Acids
- RNA
- Epigenesis, Genetic
- Biology
- Sprache
- eng
- Country
- United States
- Paginierung
- 2441 - 2449
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2023
- Titel
- Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 18
Datenquelle: PubMed
- Beziehungen:
- Eigentum von