The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Achraf Ammar
  • Khaled Trabelsi
  • Patrick Mueller
  • Bassem Bouaziz
  • Omar Boukhris
  • Jordan M Glenn
  • Nick Bott
  • Tarak Driss
  • Hamdi Chtourou
  • Notger Mueller
  • Anita Hoekelmann
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000527278800224&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3390/jcm9030835
eISSN
2077-0383
Externe Identifier
  • Clarivate Analytics Document Solution ID: LF2UT
  • PubMed Identifier: 32204500
Ausgabe der Veröffentlichung
3
Zeitschrift
JOURNAL OF CLINICAL MEDICINE
Schlüsselwörter
  • cognition
  • neuroplasticity
  • neuroinflammation
  • brain
  • polyphenols
  • meta-analysis
Artikelnummer
ARTN 835
Datum der Veröffentlichung
2020
Status
Published
Titel
The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis
Sub types
  • Review
Ausgabe der Zeitschrift
9

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:p>Context: As the food industry is continually involved in the development of new attractive alternative therapeutic agents, the evaluation of the beneficial impact of (poly)phenols on cognitive and brain function during aging has gained increasing interest. Objective: This systematic review and meta-analysis aimed to evaluate the acute and chronic effects of (poly)phenol-rich diet supplementation on cognitive function and brain health in aging adults. Data Sources: PubMed and Web of Science databases were searched for relevant randomized placebo-controlled trials (RCTs) published from inception to July 2019. Study Selection: Two researchers independently screened 4303 records, using the PICOS criteria: Participants were aging adults; Intervention was based on acute and/or chronic (poly)phenols-rich supplementation; Comparator was any comparator; Outcomes included cognitive function and neuroprotective measures; and Study design was RCTs. A third researcher was consulted when discrepancies arose. Fifteen high-quality (mean PEDro score = 8.8 ± 0.56) RCTs (total participants: 918 healthy older adults) were included in the final sample. Data Extraction: Information on study design, employed treatment, characteristics of participants, outcomes, and the correspondent assessing methods were extracted. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Data Analysis and Results: A random-effects meta-analysis was used to pool estimates across studies. Effect size (ES) and its 95% confidence interval (CI) was calculated. Pooled results yielded a trivial ES (−0.2 to 0.03) for brain-derived neurotrophic factor and neuroinflammatory parameters and small (0.36) to moderate (0.82) ES for executive functions. Conclusion: This meta-analysis failed to provide evidence regarding the neuroprotective and anti-inflammatory effect of (poly)phenols supplementation in aging adults. However, findings from individual studies, included in this systematic review, suggest polyphenol-rich supplementation may improve some cognitive and brain functions in older adults. The beneficial effect of polyphenols seems to depend on ingested dose and bioavailability. Results suggest at least an intermediate dose (≥500 mg), and intermediate (≈9%) to high (43%) bioavailability rates are needed to cross the brain blood barrier and to exert a significant effect on cognitive health.</jats:p>
Autoren
  • Achraf Ammar
  • Khaled Trabelsi
  • Patrick Müller
  • Bassem Bouaziz
  • Omar Boukhris
  • Jordan M Glenn
  • Nick Bott
  • Tarak Driss
  • Hamdi Chtourou
  • Notger Müller
  • Anita Hökelmann
DOI
10.3390/jcm9030835
eISSN
2077-0383
Ausgabe der Veröffentlichung
3
Zeitschrift
Journal of Clinical Medicine
Sprache
en
Online publication date
2020
Paginierung
835 - 835
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/jcm9030835
Datum der Datenerfassung
2020
Titel
The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis
Ausgabe der Zeitschrift
9

Datenquelle: Crossref

Abstract
<h4>Context</h4>As the food industry is continually involved in the development of new attractive alternative therapeutic agents, the evaluation of the beneficial impact of (poly)phenols on cognitive and brain function during aging has gained increasing interest.<h4>Objective</h4>This systematic review and meta-analysis aimed to evaluate the acute and chronic effects of (poly)phenol-rich diet supplementation on cognitive function and brain health in aging adults.<h4>Data sources</h4>PubMed and Web of Science databases were searched for relevant randomized placebo-controlled trials (RCTs) published from inception to July 2019.<h4>Study selection</h4>Two researchers independently screened 4303 records, using the PICOS criteria: Participants were aging adults; Intervention was based on acute and/or chronic (poly)phenols-rich supplementation; Comparator was any comparator; Outcomes included cognitive function and neuroprotective measures; and Study design was RCTs. A third researcher was consulted when discrepancies arose. Fifteen high-quality (mean PEDro score = 8.8 ± 0.56) RCTs (total participants: 918 healthy older adults) were included in the final sample.<h4>Data extraction</h4>Information on study design, employed treatment, characteristics of participants, outcomes, and the correspondent assessing methods were extracted. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Data Analysis and Results: A random-effects meta-analysis was used to pool estimates across studies. Effect size (ES) and its 95% confidence interval (CI) was calculated. Pooled results yielded a trivial ES (-0.2 to 0.03) for brain-derived neurotrophic factor and neuroinflammatory parameters and small (0.36) to moderate (0.82) ES for executive functions.<h4>Conclusion</h4>This meta-analysis failed to provide evidence regarding the neuroprotective and anti-inflammatory effect of (poly)phenols supplementation in aging adults. However, findings from individual studies, included in this systematic review, suggest polyphenol-rich supplementation may improve some cognitive and brain functions in older adults. The beneficial effect of polyphenols seems to depend on ingested dose and bioavailability. Results suggest at least an intermediate dose (≥500 mg), and intermediate (≈9%) to high (43%) bioavailability rates are needed to cross the brain blood barrier and to exert a significant effect on cognitive health.
Addresses
  • Institute of Sport Sciences, Otto-von-Guericke University, 39104 Magdeburg, Germany.
Autoren
  • Achraf Ammar
  • Khaled Trabelsi
  • Patrick Müller
  • Bassem Bouaziz
  • Omar Boukhris
  • Jordan M Glenn
  • Nick Bott
  • Tarak Driss
  • Hamdi Chtourou
  • Notger Müller
  • Anita Hökelmann
DOI
10.3390/jcm9030835
eISSN
2077-0383
Externe Identifier
  • PubMed Identifier: 32204500
  • PubMed Central ID: PMC7141326
Open access
true
ISSN
2077-0383
Ausgabe der Veröffentlichung
3
Zeitschrift
Journal of clinical medicine
Sprache
eng
Medium
Electronic
Online publication date
2020
Open access status
Open Access
Paginierung
E835
Datum der Veröffentlichung
2020
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2020
Titel
The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis.
Sub types
  • review-article
  • Review
  • Journal Article
Ausgabe der Zeitschrift
9

Files

https://www.mdpi.com/2077-0383/9/3/835/pdf?version=1584623697 https://europepmc.org/articles/PMC7141326?pdf=render

Datenquelle: Europe PubMed Central

Abstract
CONTEXT: As the food industry is continually involved in the development of new attractive alternative therapeutic agents, the evaluation of the beneficial impact of (poly)phenols on cognitive and brain function during aging has gained increasing interest. OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the acute and chronic effects of (poly)phenol-rich diet supplementation on cognitive function and brain health in aging adults. DATA SOURCES: PubMed and Web of Science databases were searched for relevant randomized placebo-controlled trials (RCTs) published from inception to July 2019. STUDY SELECTION: Two researchers independently screened 4303 records, using the PICOS criteria: Participants were aging adults; Intervention was based on acute and/or chronic (poly)phenols-rich supplementation; Comparator was any comparator; Outcomes included cognitive function and neuroprotective measures; and Study design was RCTs. A third researcher was consulted when discrepancies arose. Fifteen high-quality (mean PEDro score = 8.8 ± 0.56) RCTs (total participants: 918 healthy older adults) were included in the final sample. DATA EXTRACTION: Information on study design, employed treatment, characteristics of participants, outcomes, and the correspondent assessing methods were extracted. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Data Analysis and Results: A random-effects meta-analysis was used to pool estimates across studies. Effect size (ES) and its 95% confidence interval (CI) was calculated. Pooled results yielded a trivial ES (-0.2 to 0.03) for brain-derived neurotrophic factor and neuroinflammatory parameters and small (0.36) to moderate (0.82) ES for executive functions. CONCLUSION: This meta-analysis failed to provide evidence regarding the neuroprotective and anti-inflammatory effect of (poly)phenols supplementation in aging adults. However, findings from individual studies, included in this systematic review, suggest polyphenol-rich supplementation may improve some cognitive and brain functions in older adults. The beneficial effect of polyphenols seems to depend on ingested dose and bioavailability. Results suggest at least an intermediate dose (≥500 mg), and intermediate (≈9%) to high (43%) bioavailability rates are needed to cross the brain blood barrier and to exert a significant effect on cognitive health.
Date of acceptance
2020
Autoren
  • Achraf Ammar
  • Khaled Trabelsi
  • Patrick Müller
  • Bassem Bouaziz
  • Omar Boukhris
  • Jordan M Glenn
  • Nick Bott
  • Tarak Driss
  • Hamdi Chtourou
  • Notger Müller
  • Anita Hökelmann
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/32204500
DOI
10.3390/jcm9030835
Externe Identifier
  • PubMed Central ID: PMC7141326
ISSN
2077-0383
Ausgabe der Veröffentlichung
3
Zeitschrift
J Clin Med
Schlüsselwörter
  • brain
  • cognition
  • meta-analysis
  • neuroinflammation
  • neuroplasticity
  • polyphenols
Sprache
eng
Country
Switzerland
PII
jcm9030835
Datum der Veröffentlichung
2020
Status
Published online
Titel
The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
9

Datenquelle: PubMed

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