Effects of Polyphenol-Rich Interventions on Cognition and Brain Health in Healthy Young and Middle-Aged Adults: Systematic Review and Meta-Analysis

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Achraf Ammar
  • Khaled Trabelsi
  • Omar Boukhris
  • Bassem Bouaziz
  • Patrick Mueller
  • Jordan M Glenn
  • Nicholas T Bott
  • Notger Mueller
  • Hamdi Chtourou
  • Tarak Driss
  • Anita Hokelmann
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000540223800355&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3390/jcm9051598
eISSN
2077-0383
Externe Identifier
  • Clarivate Analytics Document Solution ID: LY0OO
  • PubMed Identifier: 32466148
Ausgabe der Veröffentlichung
5
Zeitschrift
JOURNAL OF CLINICAL MEDICINE
Schlüsselwörter
  • cognition
  • neuroplasticity
  • brain
  • polyphenols
  • meta-analysis
Artikelnummer
ARTN 1598
Datum der Veröffentlichung
2020
Status
Published
Titel
Effects of Polyphenol-Rich Interventions on Cognition and Brain Health in Healthy Young and Middle-Aged Adults: Systematic Review and Meta-Analysis
Sub types
  • Review
Ausgabe der Zeitschrift
9

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:p>Context: Affecting older and even some younger adults, neurodegenerative disease represents a global public health concern and has been identified as a research priority. To date, most anti-aging interventions have examined older adults, but little is known about the effects of polyphenol interventions on brain-related aging processes in healthy young and middle-aged adults. Objective: This systematic review and meta-analysis aimed to evaluate the acute and chronic effects of (poly)phenol-rich diet supplementation on cognitive function and brain health in young and middle-aged adults. In July 2019, two electronic databases (PubMed and Web of Science) were used to search for relevant trials examining the effect of acute or chronic (poly)phenol-rich supplementation on cognitive function and neuroprotective measures in young and middle-aged adults (&lt;60 years old). A total of 4303 records were screened by two researchers using the PICOS criteria. Fifteen high quality (mean PEDro score = 8.8 ± 0.58) trials with 401 total participants were included in the final analyses. Information on treatment, study design, characteristics of participants, outcomes and used tools were extracted following PRISMA guidelines. When items were shown to be sufficiently comparable, a random-effects meta-analysis was used to pool estimates across studies. Effect size (ES) and its 95% confidence interval (CI) was calculated. The meta-analysis indicated that (poly)phenol supplementation significantly increased brain-derived neurotrophic factor (ES = 3.259, p = 0.033), which was accompanied by higher performance in serial (7s) subtraction (ES = 1.467, p = 0.001) and decreases in simple reaction time (ES = −0.926, p = 0.015) and mental fatigue (ES = −3.521, p = 0.010). Data related to cognitive function were skewed towards an effect from acute compared to chronic polyphenol intervention; data related to BDNF were skewed toward an effect from higher bioavailability phenolic components. Conclusion: This meta-analysis provides promising findings regarding the usefulness of polyphenol-rich intervention as an inexpensive approach for enhancing circulation of pro-cognitive neurotrophic factors. These beneficial effects appear to depend on the supplementation protocols. An early acute and/or chronic application of low- to high-dose phenolic components with high bioavailability rates (≥30%) at a younger age appear to provide more promising effects.</jats:p>
Autoren
  • Achraf Ammar
  • Khaled Trabelsi
  • Omar Boukhris
  • Bassem Bouaziz
  • Patrick Müller
  • Jordan M Glenn
  • Nicholas T Bott
  • Notger Müller
  • Hamdi Chtourou
  • Tarak Driss
  • Anita Hökelmann
DOI
10.3390/jcm9051598
eISSN
2077-0383
Ausgabe der Veröffentlichung
5
Zeitschrift
Journal of Clinical Medicine
Sprache
en
Online publication date
2020
Paginierung
1598 - 1598
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/jcm9051598
Datum der Datenerfassung
2020
Titel
Effects of Polyphenol-Rich Interventions on Cognition and Brain Health in Healthy Young and Middle-Aged Adults: Systematic Review and Meta-Analysis
Ausgabe der Zeitschrift
9

Datenquelle: Crossref

Abstract
<h4>Context</h4>Affecting older and even some younger adults, neurodegenerative disease represents a global public health concern and has been identified as a research priority. To date, most anti-aging interventions have examined older adults, but little is known about the effects of polyphenol interventions on brain-related aging processes in healthy young and middle-aged adults.<h4>Objective</h4>This systematic review and meta-analysis aimed to evaluate the acute and chronic effects of (poly)phenol-rich diet supplementation on cognitive function and brain health in young and middle-aged adults. In July 2019, two electronic databases (PubMed and Web of Science) were used to search for relevant trials examining the effect of acute or chronic (poly)phenol-rich supplementation on cognitive function and neuroprotective measures in young and middle-aged adults (<60 years old). A total of 4303 records were screened by two researchers using the PICOS criteria. Fifteen high quality (mean PEDro score = 8.8 ± 0.58) trials with 401 total participants were included in the final analyses. Information on treatment, study design, characteristics of participants, outcomes and used tools were extracted following PRISMA guidelines. When items were shown to be sufficiently comparable, a random-effects meta-analysis was used to pool estimates across studies. Effect size (ES) and its 95% confidence interval (CI) was calculated. The meta-analysis indicated that (poly)phenol supplementation significantly increased brain-derived neurotrophic factor (ES = 3.259, <i>p</i> = 0.033), which was accompanied by higher performance in serial (7s) subtraction (ES = 1.467, <i>p</i> = 0.001) and decreases in simple reaction time (ES = -0.926, <i>p</i> = 0.015) and mental fatigue (ES = -3.521 <i>p</i> = 0.010). Data related to cognitive function were skewed towards an effect from acute compared to chronic polyphenol intervention; data related to BDNF were skewed toward an effect from higher bioavailability phenolic components.<h4>Conclusion</h4>This meta-analysis provides promising findings regarding the usefulness of polyphenol-rich intervention as an inexpensive approach for enhancing circulation of pro-cognitive neurotrophic factors. These beneficial effects appear to depend on the supplementation protocols. An early acute and/or chronic application of low- to high-dose phenolic components with high bioavailability rates (≥30%) at a younger age appear to provide more promising effects.
Addresses
  • Institute of Sport Sciences, Otto-von-Guericke University, 39104 Magdeburg, Germany.
Autoren
  • Achraf Ammar
  • Khaled Trabelsi
  • Omar Boukhris
  • Bassem Bouaziz
  • Patrick Müller
  • Jordan M Glenn
  • Nicholas T Bott
  • Notger Müller
  • Hamdi Chtourou
  • Tarak Driss
  • Anita Hökelmann
DOI
10.3390/jcm9051598
eISSN
2077-0383
Externe Identifier
  • PubMed Identifier: 32466148
  • PubMed Central ID: PMC7290428
Open access
true
ISSN
2077-0383
Ausgabe der Veröffentlichung
5
Zeitschrift
Journal of clinical medicine
Sprache
eng
Medium
Electronic
Online publication date
2020
Open access status
Open Access
Paginierung
E1598
Datum der Veröffentlichung
2020
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2020
Titel
Effects of Polyphenol-Rich Interventions on Cognition and Brain Health in Healthy Young and Middle-Aged Adults: Systematic Review and Meta-Analysis.
Sub types
  • review-article
  • Review
  • Journal Article
Ausgabe der Zeitschrift
9

Files

https://www.mdpi.com/2077-0383/9/5/1598/pdf?version=1590645884 https://europepmc.org/articles/PMC7290428?pdf=render

Datenquelle: Europe PubMed Central

Abstract
CONTEXT: Affecting older and even some younger adults, neurodegenerative disease represents a global public health concern and has been identified as a research priority. To date, most anti-aging interventions have examined older adults, but little is known about the effects of polyphenol interventions on brain-related aging processes in healthy young and middle-aged adults. OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the acute and chronic effects of (poly)phenol-rich diet supplementation on cognitive function and brain health in young and middle-aged adults. In July 2019, two electronic databases (PubMed and Web of Science) were used to search for relevant trials examining the effect of acute or chronic (poly)phenol-rich supplementation on cognitive function and neuroprotective measures in young and middle-aged adults (<60 years old). A total of 4303 records were screened by two researchers using the PICOS criteria. Fifteen high quality (mean PEDro score = 8.8 ± 0.58) trials with 401 total participants were included in the final analyses. Information on treatment, study design, characteristics of participants, outcomes and used tools were extracted following PRISMA guidelines. When items were shown to be sufficiently comparable, a random-effects meta-analysis was used to pool estimates across studies. Effect size (ES) and its 95% confidence interval (CI) was calculated. The meta-analysis indicated that (poly)phenol supplementation significantly increased brain-derived neurotrophic factor (ES = 3.259, p = 0.033), which was accompanied by higher performance in serial (7s) subtraction (ES = 1.467, p = 0.001) and decreases in simple reaction time (ES = -0.926, p = 0.015) and mental fatigue (ES = -3.521 p = 0.010). Data related to cognitive function were skewed towards an effect from acute compared to chronic polyphenol intervention; data related to BDNF were skewed toward an effect from higher bioavailability phenolic components. CONCLUSION: This meta-analysis provides promising findings regarding the usefulness of polyphenol-rich intervention as an inexpensive approach for enhancing circulation of pro-cognitive neurotrophic factors. These beneficial effects appear to depend on the supplementation protocols. An early acute and/or chronic application of low- to high-dose phenolic components with high bioavailability rates (≥30%) at a younger age appear to provide more promising effects.
Date of acceptance
2020
Autoren
  • Achraf Ammar
  • Khaled Trabelsi
  • Omar Boukhris
  • Bassem Bouaziz
  • Patrick Müller
  • Jordan M Glenn
  • Nicholas T Bott
  • Notger Müller
  • Hamdi Chtourou
  • Tarak Driss
  • Anita Hökelmann
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/32466148
DOI
10.3390/jcm9051598
Externe Identifier
  • PubMed Central ID: PMC7290428
ISSN
2077-0383
Ausgabe der Veröffentlichung
5
Zeitschrift
J Clin Med
Schlüsselwörter
  • brain
  • cognition
  • meta-analysis
  • neuroplasticity
  • polyphenols
Sprache
eng
Country
Switzerland
PII
jcm9051598
Datum der Veröffentlichung
2020
Status
Published online
Titel
Effects of Polyphenol-Rich Interventions on Cognition and Brain Health in Healthy Young and Middle-Aged Adults: Systematic Review and Meta-Analysis.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
9

Datenquelle: PubMed

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