A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Fabian Herold
- Berit K Labott
- Bernhard Graessler
- Nicole Halfpaap
- Corinna Langhans
- Patrick Mueller
- Achraf Ammar
- Milos Dordevic
- Anita Hoekelmann
- Notger G Mueller
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000976091900001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/healthcare10020230
- eISSN
- 2227-9032
- Externe Identifier
- Clarivate Analytics Document Solution ID: E5QS6
- PubMed Identifier: 35206845
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- HEALTHCARE
- Schlüsselwörter
- MCI
- hippocampal-prefrontal network
- handgrip strength
- exercise cognition
- aging
- brain health
- Artikelnummer
- ARTN 230
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls
- Sub types
- Article
- Ausgabe der Zeitschrift
- 10
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.</jats:p>
- Autoren
- Fabian Herold
- Berit K Labott
- Bernhard Grässler
- Nicole Halfpaap
- Corinna Langhans
- Patrick Müller
- Achraf Ammar
- Milos Dordevic
- Anita Hökelmann
- Notger G Müller
- DOI
- 10.3390/healthcare10020230
- eISSN
- 2227-9032
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Healthcare
- Sprache
- en
- Online publication date
- 2022
- Paginierung
- 230 - 230
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/healthcare10020230
- Datum der Datenerfassung
- 2022
- Titel
- A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls
- Ausgabe der Zeitschrift
- 10
Datenquelle: Crossref
- Abstract
- Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; <i>p</i> = 0.063) and left nHGS (rp (22) = 0.420; <i>p</i> = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.
- Addresses
- Department of Neurology, Medical Faculty, Otto von Guericke University, 39120 Magdeburg, Germany.
- Autoren
- Fabian Herold
- Berit K Labott
- Bernhard Grässler
- Nicole Halfpaap
- Corinna Langhans
- Patrick Müller
- Achraf Ammar
- Milos Dordevic
- Anita Hökelmann
- Notger G Müller
- DOI
- 10.3390/healthcare10020230
- eISSN
- 2227-9032
- Externe Identifier
- PubMed Identifier: 35206845
- PubMed Central ID: PMC8872145
- Funding acknowledgements
- Autonomy in Old Age (AiA): ZS/2018/08/94206; ZS/2019/07/99755
- Autonomy in Old Age: ZS/2018/08/94206; ZS/2019/07/99755
- Open access
- true
- ISSN
- 2227-9032
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Healthcare (Basel, Switzerland)
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2022
- Open access status
- Open Access
- Paginierung
- 230
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls.
- Sub types
- brief-report
- Journal Article
- Ausgabe der Zeitschrift
- 10
Files
https://www.mdpi.com/2227-9032/10/2/230/pdf?version=1644223269 https://europepmc.org/articles/PMC8872145?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.
- Date of acceptance
- 2022
- Autoren
- Fabian Herold
- Berit K Labott
- Bernhard Grässler
- Nicole Halfpaap
- Corinna Langhans
- Patrick Müller
- Achraf Ammar
- Milos Dordevic
- Anita Hökelmann
- Notger G Müller
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/35206845
- DOI
- 10.3390/healthcare10020230
- Externe Identifier
- PubMed Central ID: PMC8872145
- Funding acknowledgements
- Autonomy in Old Age (AiA): ZS/2018/08/94206; ZS/2019/07/99755
- ISSN
- 2227-9032
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Healthcare (Basel)
- Schlüsselwörter
- MCI
- aging
- brain health
- exercise cognition
- handgrip strength
- hippocampal-prefrontal network
- Sprache
- eng
- Country
- Switzerland
- PII
- healthcare10020230
- Datum der Veröffentlichung
- 2022
- Status
- Published online
- Titel
- A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 10
Datenquelle: PubMed
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- Eigentum von