Development and Phenotype of Heart Failure in Long‐Term Survivors of Childhood Cancer: The CVSS Study

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Abstract
<jats:sec sec-type="background" xml:lang="en"> <jats:title>Background</jats:title> <jats:p xml:lang="en">The CVSS (Cardiac and Vascular Late Sequelae in Long‐Term Survivors of Childhood Cancer) study aimed to investigate the prevalence of different stages of heart failure (HF) in childhood cancer survivors (CCSs) compared with the general population.</jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Methods and Results</jats:title> <jats:p xml:lang="en"> A total of 1002 CCSs (age range, 23–48 years) diagnosed with neoplasia before an age of 15 years underwent a comprehensive cardiovascular screening. An age‐ and sex‐matched sample from the population‐based GHS (Gutenberg Health Study) served as a comparison group. Although prevalence of HF was significantly higher in CCSs, prevalence of different HF stages varied strongly by specific tumor history. Compared with the population, the prevalence ratio was 2.6 (95% CI, 2.4–2.8) for HF stage A and 4.6 (95% CI, 4.1–5.1) for the composite of HF stage B to D in an age‐ and sex‐adjusted Poisson regression model. Multivariable linear regression, adjusting for tumor entities, age, sex, and cardiovascular risk factors, revealed a lower left ventricular ejection fraction in patients with history of bone tumors ( <jats:italic>β,</jats:italic> −4.30 [95% CI, −5.70 to −2.80]), soft tissue sarcoma ( <jats:italic>β,</jats:italic> −1.60 [95% CI, −2.90 to −0.30]), and renal tumors ( <jats:italic>β,</jats:italic> −1.60 [95% CI, −2.80 to −0.29]) compared with the population. The same model for the diastolic marker, ratio of the peak early diastolic filling velocity/lateral mitral annular early diastolic velocity, showed an association only with cardiovascular risk factors but not with tumor entities. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Conclusions</jats:title> <jats:p xml:lang="en">The prevalence of HF stage A to D was significantly higher among long‐term CCSs compared with the population and varied strongly by tumor entity. Systolic dysfunction was primarily associated with tumor entities, whereas diastolic dysfunction was associated with a higher burden of cardiovascular risk factors in CCSs.</jats:p> </jats:sec>
Autoren
  • Sebastian Göbel
  • Arthur Wingerter
  • Jürgen H Prochaska
  • Andreas Schulz
  • Marie A Neu
  • Nicole Henninger
  • Claudia Spix
  • Manfred Beutel
  • Karl Lackner
  • Thomas Münzel
  • Carolyn S Lam
  • Hiltrud Merzenich
  • Jörg Faber
  • Philipp S Wild
DOI
10.1161/jaha.123.030020
eISSN
2047-9980
Ausgabe der Veröffentlichung
19
Zeitschrift
Journal of the American Heart Association
Sprache
en
Datum der Veröffentlichung
2023
Status
Published
Herausgeber
Ovid Technologies (Wolters Kluwer Health)
Herausgeber URL
http://dx.doi.org/10.1161/jaha.123.030020
Datum der Datenerfassung
2024
Titel
Development and Phenotype of Heart Failure in Long‐Term Survivors of Childhood Cancer: The CVSS Study
Ausgabe der Zeitschrift
12

Datenquelle: Crossref

Andere Metadatenquellen:
Author's licence
CC-BY-NC-ND
Autoren
  • Sebastian Göbel
  • Arthur Wingerter
  • Jürgen H Prochaska
  • Andreas Schulz
  • Marie A Neu
  • Nicole Henninger
  • Claudia Spix
  • Manfred Beutel
  • Karl Lackner
  • Thomas Münzel
  • Carolyn S Lam
  • Hiltrud Merzenich
  • Jörg Faber
  • Philipp S Wild
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-G
Resource version
Published version
DOI
10.1161/JAHA.123.030020
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft (DFG)|491381577|Open-Access-Publikationskosten 2022–2024 Universität Mainz - Universitätsmedizin
File(s) embargoed
false
Open access
true
ISSN
2047-9980
Ausgabe der Veröffentlichung
19
Zeitschrift
Journal of the American Heart Association
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
e030020
Datum der Veröffentlichung
2023
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/9996
Herausgeber
Association
Datum der Datenerfassung
2024
Datum, an dem der Datensatz öffentlich gemacht wurde
2024
Zugang
Public
Titel
Development and phenotype of heart failure in long-term survivors of childhood cancer : the CVSS study
Ausgabe der Zeitschrift
12

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development_and_phenotype_of_-20240123171432013.pdf

Datenquelle: OPENSCIENCE.UB

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