Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Jiancai Li
  • Rayko Halitschke
  • Dapeng Li
  • Christian Paetz
  • Haichao Su
  • Sven Heiling
  • Shuqing Xu
  • Ian T Baldwin
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000607782500047&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1126/science.abe4713
eISSN
1095-9203
Externe Identifier
  • Clarivate Analytics Document Solution ID: PS2UI
  • PubMed Identifier: 33446550
ISSN
0036-8075
Ausgabe der Veröffentlichung
6526
Zeitschrift
SCIENCE
Paginierung
255 - +
Datum der Veröffentlichung
2021
Status
Published
Titel
Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity
Sub types
  • Article
Ausgabe der Zeitschrift
371

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:title>Diterpenoids inhibit lipid biosynthesis</jats:title> <jats:p> Plants make a variety of molecules that serve to protect them against hungry insects. Li <jats:italic>et al.</jats:italic> analyzed the balance between plants defending themselves and plants poisoning themselves. In wild tobacco ( <jats:italic>Nicotiana attenuata</jats:italic> ), two cytochrome P450 enzymes work within the biosynthetic pathway of 17-hydroxygeranyllinalool diterpene glycosides to help prevent the accumulation of toxic diterpene derivatives. Those same diterpene derivatives are formed in an insect herbivore after ingestion and cause toxicity by inhibiting sphingolipid biosynthesis in both plant and insect. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6526" page="255" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abe4713">255</jats:related-article> </jats:p>
Autoren
  • Jiancai Li
  • Rayko Halitschke
  • Dapeng Li
  • Christian Paetz
  • Haichao Su
  • Sven Heiling
  • Shuqing Xu
  • Ian T Baldwin
DOI
10.1126/science.abe4713
eISSN
1095-9203
ISSN
0036-8075
Ausgabe der Veröffentlichung
6526
Zeitschrift
Science
Sprache
en
Paginierung
255 - 260
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
American Association for the Advancement of Science (AAAS)
Herausgeber URL
http://dx.doi.org/10.1126/science.abe4713
Datum der Datenerfassung
2024
Titel
Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity
Ausgabe der Zeitschrift
371

Datenquelle: Crossref

Abstract
Many plant specialized metabolites function in herbivore defense, and abrogating particular steps in their biosynthetic pathways frequently causes autotoxicity. However, the molecular mechanisms underlying their defense and autotoxicity remain unclear. Here, we show that silencing two cytochrome P450s involved in diterpene biosynthesis in the wild tobacco <i>Nicotiana attenuata</i> causes severe autotoxicity symptoms that result from the inhibition of sphingolipid biosynthesis by noncontrolled hydroxylated diterpene derivatives. Moreover, the diterpenes' defensive function is achieved by inhibiting herbivore sphingolipid biosynthesis through postingestive backbone hydroxylation products. Thus, by regulating metabolic modifications, tobacco plants avoid autotoxicity and gain herbivore defense. The postdigestive duet that occurs between plants and their insect herbivores can reflect the plant's solutions to the "toxic waste dump" problem of using potent chemical defenses.
Addresses
  • Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, D-07745 Jena, Germany.
Autoren
  • Jiancai Li
  • Rayko Halitschke
  • Dapeng Li
  • Christian Paetz
  • Haichao Su
  • Sven Heiling
  • Shuqing Xu
  • Ian T Baldwin
DOI
10.1126/science.abe4713
eISSN
1095-9203
Externe Identifier
  • PubMed Identifier: 33446550
Funding acknowledgements
  • Max-Planck-Gesellschaft:
  • University of Münster:
  • European Research Council: 293926
  • Deutsche Forschungsgemeinschaft: 239748522
Open access
false
ISSN
0036-8075
Ausgabe der Veröffentlichung
6526
Zeitschrift
Science (New York, N.Y.)
Schlüsselwörter
  • Animals
  • Manduca
  • Diterpenes
  • Cytochrome P-450 Enzyme System
  • Oxidoreductases
  • Glucosides
  • Sphingolipids
  • Hydroxylation
  • Herbivory
  • Nicotiana
Sprache
eng
Medium
Print
Paginierung
255 - 260
Datum der Veröffentlichung
2021
Status
Published
Datum der Datenerfassung
2021
Titel
Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
371

Datenquelle: Europe PubMed Central

Abstract
Many plant specialized metabolites function in herbivore defense, and abrogating particular steps in their biosynthetic pathways frequently causes autotoxicity. However, the molecular mechanisms underlying their defense and autotoxicity remain unclear. Here, we show that silencing two cytochrome P450s involved in diterpene biosynthesis in the wild tobacco Nicotiana attenuata causes severe autotoxicity symptoms that result from the inhibition of sphingolipid biosynthesis by noncontrolled hydroxylated diterpene derivatives. Moreover, the diterpenes' defensive function is achieved by inhibiting herbivore sphingolipid biosynthesis through postingestive backbone hydroxylation products. Thus, by regulating metabolic modifications, tobacco plants avoid autotoxicity and gain herbivore defense. The postdigestive duet that occurs between plants and their insect herbivores can reflect the plant's solutions to the "toxic waste dump" problem of using potent chemical defenses.
Date of acceptance
2020
Autoren
  • Jiancai Li
  • Rayko Halitschke
  • Dapeng Li
  • Christian Paetz
  • Haichao Su
  • Sven Heiling
  • Shuqing Xu
  • Ian T Baldwin
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/33446550
DOI
10.1126/science.abe4713
eISSN
1095-9203
Ausgabe der Veröffentlichung
6526
Zeitschrift
Science
Schlüsselwörter
  • Animals
  • Cytochrome P-450 Enzyme System
  • Diterpenes
  • Glucosides
  • Herbivory
  • Hydroxylation
  • Manduca
  • Oxidoreductases
  • Sphingolipids
  • Nicotiana
Sprache
eng
Country
United States
Paginierung
255 - 260
PII
371/6526/255
Datum der Veröffentlichung
2021
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
371

Datenquelle: PubMed

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