High Altitude Adaptation and Phylogenetic Analysis of Tibetan Horse Based on the Mitochondrial Genome

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Shuqing Xu
  • Jiangbai Luosang
  • Sang Hua
  • Jian He
  • Asan Ciren
  • Wei Wang
  • Xiaomei Tong
  • Yu Liang
  • Jian Wang
  • Xiaoguang Zheng
DOI
10.1016/s1673-8527(07)60081-2
ISSN
1673-8527
Ausgabe der Veröffentlichung
8
Zeitschrift
Journal of Genetics and Genomics
Sprache
en
Paginierung
720 - 729
Datum der Veröffentlichung
2007
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/s1673-8527(07)60081-2
Datum der Datenerfassung
2019
Titel
High Altitude Adaptation and Phylogenetic Analysis of Tibetan Horse Based on the Mitochondrial Genome
Ausgabe der Zeitschrift
34

Datenquelle: Crossref

Andere Metadatenquellen:
Abstract
To investigate genetic mechanisms of high altitude adaptations of animals living in the Tibetan Plateau, three mitochondrial genomes (mt-genome) of Tibetan horses living in Naqu (4,500 m) of Tibetan, Zhongdian (3,300 m) and Deqin (3,100 m) of Yunnan province were sequenced. The structures and lengths of these three mt-genomes are similar to the Cheju horse, which is related to Tibetan horses, but little shorter than the Swedish horse. The pair-wise identity of these three horses on nucleotide level is more than 99.3%. When the gene encoding the mitochondrial protein of Tibetan horses was analyzed, we found that NADH6 has higher non-synonymous mutation rate in all of three Tibetan horses. This implies that NADH6 may play a role in Tibetan horses' high altitude adaptation. NADH6 is one of the subunits of the complex I in the respiratory chain. Furthermore, 7 D-loop sequences of Tibetan horse from different areas were sequenced, and the phylogeny tree was constructed to study the origin and evolutionary history of Tibetan horses. The result showed that the genetic diverse was high among Tibetan horses. All of Tibetan horses from Naqu were clustered into one clade, and Tibetan horses from Zhongdian and Deqin were clustered into others clades. The first molecular evidence of Tibetan horses indicated in this study is that Tibetan horse population might have multiple origins.
Addresses
  • Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Autoren
  • Shuqing Xu
  • Jiangbai Luosang
  • Sang Hua
  • Jian He
  • Asan Ciren
  • Wei Wang
  • Xiaomei Tong
  • Yu Liang
  • Jian Wang
  • Xiaoguang Zheng
DOI
10.1016/s1673-8527(07)60081-2
Externe Identifier
  • PubMed Identifier: 17707216
Open access
false
ISSN
1673-8527
Ausgabe der Veröffentlichung
8
Zeitschrift
Journal of genetics and genomics = Yi chuan xue bao
Schlüsselwörter
  • Animals
  • Horses
  • DNA, Mitochondrial
  • Sequence Analysis, DNA
  • Altitude
  • Adaptation, Biological
  • Evolution, Molecular
  • Phylogeny
  • Base Composition
  • Mutation
  • Open Reading Frames
  • Tibet
  • Genome, Mitochondrial
  • Genetic Variation
Sprache
eng
Medium
Print
Paginierung
720 - 729
Datum der Veröffentlichung
2007
Status
Published
Datum der Datenerfassung
2007
Titel
High altitude adaptation and phylogenetic analysis of Tibetan horse based on the mitochondrial genome.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
34

Datenquelle: Europe PubMed Central

Abstract
To investigate genetic mechanisms of high altitude adaptations of animals living in the Tibetan Plateau, three mitochondrial genomes (mt-genome) of Tibetan horses living in Naqu (4,500 m) of Tibetan, Zhongdian (3,300 m) and Deqin (3,100 m) of Yunnan province were sequenced. The structures and lengths of these three mt-genomes are similar to the Cheju horse, which is related to Tibetan horses, but little shorter than the Swedish horse. The pair-wise identity of these three horses on nucleotide level is more than 99.3%. When the gene encoding the mitochondrial protein of Tibetan horses was analyzed, we found that NADH6 has higher non-synonymous mutation rate in all of three Tibetan horses. This implies that NADH6 may play a role in Tibetan horses' high altitude adaptation. NADH6 is one of the subunits of the complex I in the respiratory chain. Furthermore, 7 D-loop sequences of Tibetan horse from different areas were sequenced, and the phylogeny tree was constructed to study the origin and evolutionary history of Tibetan horses. The result showed that the genetic diverse was high among Tibetan horses. All of Tibetan horses from Naqu were clustered into one clade, and Tibetan horses from Zhongdian and Deqin were clustered into others clades. The first molecular evidence of Tibetan horses indicated in this study is that Tibetan horse population might have multiple origins.
Date of acceptance
2006
Autoren
  • Shuqing Xu
  • Jiangbai Luosang
  • Sang Hua
  • Jian He
  • Asan Ciren
  • Wei Wang
  • Xiaomei Tong
  • Yu Liang
  • Jian Wang
  • Xiaoguang Zheng
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/17707216
DOI
10.1016/S1673-8527(07)60081-2
ISSN
1673-8527
Ausgabe der Veröffentlichung
8
Zeitschrift
J Genet Genomics
Schlüsselwörter
  • Adaptation, Biological
  • Altitude
  • Animals
  • Base Composition
  • DNA, Mitochondrial
  • Evolution, Molecular
  • Genetic Variation
  • Genome, Mitochondrial
  • Horses
  • Mutation
  • Open Reading Frames
  • Phylogeny
  • Sequence Analysis, DNA
  • Tibet
Sprache
eng
Country
China
Paginierung
720 - 729
PII
S1673-8527(07)60081-2
Datum der Veröffentlichung
2007
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
High altitude adaptation and phylogenetic analysis of Tibetan horse based on the mitochondrial genome.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
34

Datenquelle: PubMed

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