Centrins, gatekeepers for the light-dependent translocation of transducin through the photoreceptor cell connecting cilium
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Andreas Giessl
- Philipp Trojan
- Sebastian Rausch
- Alexander Pulvermueller
- Uwe Wolfrum
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000242674400010&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.visres.2006.07.029
- Externe Identifier
- Clarivate Analytics Document Solution ID: 114OB
- PubMed Identifier: 17027897
- ISSN
- 0042-6989
- Ausgabe der Veröffentlichung
- 27
- Zeitschrift
- VISION RESEARCH
- Schlüsselwörter
- centrin
- transducin
- photoreceptors
- light-dependent translocation
- connecting cilium
- Paginierung
- 4502 - 4509
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Titel
- Centrins, gatekeepers for the light-dependent translocation of transducin through the photoreceptor cell connecting cilium
- Sub types
- Article
- Ausgabe der Zeitschrift
- 46
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Andreas Gießl
- Philipp Trojan
- Sebastian Rausch
- Alexander Pulvermüller
- Uwe Wolfrum
- DOI
- 10.1016/j.visres.2006.07.029
- ISSN
- 0042-6989
- Ausgabe der Veröffentlichung
- 27
- Zeitschrift
- Vision Research
- Sprache
- en
- Paginierung
- 4502 - 4509
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.visres.2006.07.029
- Datum der Datenerfassung
- 2021
- Titel
- Centrins, gatekeepers for the light-dependent translocation of transducin through the photoreceptor cell connecting cilium
- Ausgabe der Zeitschrift
- 46
Datenquelle: Crossref
- Abstract
- Centrins are members of a highly conserved subgroup of the EF-hand superfamily of Ca(2+)-binding proteins commonly associated with centrosome-related structures. In the retina, centrins are also prominent components of the photoreceptor cell ciliary apparatus. Centrin isoforms are differentially localized at the basal body and in the lumen of the connecting cilium. All molecular exchanges between the inner and outer segments occur through this narrow connecting cilium. Ca(2+)-activated centrin isoforms bind to the visual heterotrimeric G-protein transducin via an interaction with the betagamma-subunit. Ca(2+)-dependent assemblies of centrin/G-protein complexes may regulate the transducin movement through the connecting cilium. Formation of this complex represents a novel mechanism in regulation of translocation of signaling proteins in sensory cells, as well as a potential link between molecular trafficking and signal transduction in general.
- Addresses
- Johannes Gutenberg-University, Institute of Zoology, Department of Cell and Matrix Biology, Mainz, Germany.
- Autoren
- Andreas Giessl
- Philipp Trojan
- Sebastian Rausch
- Alexander Pulvermüller
- Uwe Wolfrum
- DOI
- 10.1016/j.visres.2006.07.029
- eISSN
- 1878-5646
- Externe Identifier
- PubMed Identifier: 17027897
- Open access
- false
- ISSN
- 0042-6989
- Ausgabe der Veröffentlichung
- 27
- Zeitschrift
- Vision research
- Schlüsselwörter
- Cilia
- Centrosome
- Animals
- Vertebrates
- Transducin
- Calcium-Binding Proteins
- Photic Stimulation
- Protein Transport
- Phosphorylation
- Photoreceptor Cells
- Vision, Ocular
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2006
- Paginierung
- 4502 - 4509
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Datum der Datenerfassung
- 2006
- Titel
- Centrins, gatekeepers for the light-dependent translocation of transducin through the photoreceptor cell connecting cilium.
- Sub types
- Research Support, Non-U.S. Gov't
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 46
Datenquelle: Europe PubMed Central
- Abstract
- Centrins are members of a highly conserved subgroup of the EF-hand superfamily of Ca(2+)-binding proteins commonly associated with centrosome-related structures. In the retina, centrins are also prominent components of the photoreceptor cell ciliary apparatus. Centrin isoforms are differentially localized at the basal body and in the lumen of the connecting cilium. All molecular exchanges between the inner and outer segments occur through this narrow connecting cilium. Ca(2+)-activated centrin isoforms bind to the visual heterotrimeric G-protein transducin via an interaction with the betagamma-subunit. Ca(2+)-dependent assemblies of centrin/G-protein complexes may regulate the transducin movement through the connecting cilium. Formation of this complex represents a novel mechanism in regulation of translocation of signaling proteins in sensory cells, as well as a potential link between molecular trafficking and signal transduction in general.
- Date of acceptance
- 2006
- Autoren
- Andreas Giessl
- Philipp Trojan
- Sebastian Rausch
- Alexander Pulvermüller
- Uwe Wolfrum
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/17027897
- DOI
- 10.1016/j.visres.2006.07.029
- ISSN
- 0042-6989
- Ausgabe der Veröffentlichung
- 27
- Zeitschrift
- Vision Res
- Schlüsselwörter
- Animals
- Calcium-Binding Proteins
- Centrosome
- Cilia
- Phosphorylation
- Photic Stimulation
- Photoreceptor Cells
- Protein Transport
- Transducin
- Vertebrates
- Vision, Ocular
- Sprache
- eng
- Country
- England
- Paginierung
- 4502 - 4509
- PII
- S0042-6989(06)00359-2
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2007
- Titel
- Centrins, gatekeepers for the light-dependent translocation of transducin through the photoreceptor cell connecting cilium.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
- Ausgabe der Zeitschrift
- 46
Datenquelle: PubMed
- Beziehungen:
- Eigentum von