Adhesion GPCR-Related Protein Networks

Autoren

Barbara Knapp
Uwe Wolfrum

DOI

10.1007/978-3-319-41523-9_8

ISBN-13

9783319415215

Online publication date

2016

Paginierung

147 - 178

Buchtitel

Adhesion G Protein-coupled Receptors

Datum der Veröffentlichung

2016

Status

Published

Herausgeber

Springer International Publishing

Herausgeber URL

http://dx.doi.org/10.1007/978-3-319-41523-9_8

Datum der Datenerfassung

2019

Titel

Adhesion GPCR-Related Protein Networks

Datenquelle: Crossref

Abstract

Adhesion G protein-coupled receptors (aGPCRs/ADGRs) are unique receptors that combine cell adhesion and signaling functions. Protein networks related to ADGRs exert diverse functions, e.g., in tissue polarity, cell migration, nerve cell function, or immune response, and are regulated via different mechanisms. The large extracellular domain of ADGRs is capable of mediating cell-cell or cell-matrix protein interactions. Their intracellular surface and domains are coupled to downstream signaling pathways and often bind to scaffold proteins, organizing membrane-associated protein complexes. The cohesive interplay between ADGR-related network components is essential to prevent severe disease-causing damage in numerous cell types. Consequently, in recent years, attention has focused on the decipherment of the precise molecular composition of ADGR protein complexes and interactomes in various cellular modules. In this chapter, we discuss the affiliation of ADGR networks to cellular modules and how they can be regulated, pinpointing common features in the networks related to the diverse ADGRs. Detailed decipherment of the composition of protein networks should provide novel targets for the development of novel therapies with the aim to cure human diseases related to ADGRs.

Addresses

Cell and Matrix Biology, Institute of Zoology, Johannes Gutenberg University of Mainz, Johannes von Muellerweg 6, Mainz, 55099, Germany.

Autoren

Barbara Knapp
Uwe Wolfrum

DOI

10.1007/978-3-319-41523-9_8

Open access

false

Schlüsselwörter

Cell Membrane
Animals
Humans
Receptors, G-Protein-Coupled
Protein Interaction Mapping
Proteomics
Cell Adhesion
Signal Transduction
Binding Sites
Protein Binding
Structure-Activity Relationship
Models, Molecular
Protein Interaction Domains and Motifs
Protein Interaction Maps

Medium

Print

Paginierung

147 - 178

Datum der Veröffentlichung

2016

Status

Published

Datum der Datenerfassung

2016

Titel

Adhesion GPCR-Related Protein Networks.

Ausgabe der Zeitschrift

234

Datenquelle: Europe PubMed Central

Abstract

Adhesion G protein-coupled receptors (aGPCRs/ADGRs) are unique receptors that combine cell adhesion and signaling functions. Protein networks related to ADGRs exert diverse functions, e.g., in tissue polarity, cell migration, nerve cell function, or immune response, and are regulated via different mechanisms. The large extracellular domain of ADGRs is capable of mediating cell-cell or cell-matrix protein interactions. Their intracellular surface and domains are coupled to downstream signaling pathways and often bind to scaffold proteins, organizing membrane-associated protein complexes. The cohesive interplay between ADGR-related network components is essential to prevent severe disease-causing damage in numerous cell types. Consequently, in recent years, attention has focused on the decipherment of the precise molecular composition of ADGR protein complexes and interactomes in various cellular modules. In this chapter, we discuss the affiliation of ADGR networks to cellular modules and how they can be regulated, pinpointing common features in the networks related to the diverse ADGRs. Detailed decipherment of the composition of protein networks should provide novel targets for the development of novel therapies with the aim to cure human diseases related to ADGRs.

Autoren

Barbara Knapp
Uwe Wolfrum

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/27832488

DOI

10.1007/978-3-319-41523-9_8

Schlüsselwörter

ADGR
Adhesion GPCR
Adhesion complexes
Affinity proteomics
Brain-specific angiogenesis inhibitor
GPR98
Latrophillin
Protein networks
Signaling pathways
VLGR1
Animals
Binding Sites
Cell Adhesion
Cell Membrane
Humans
Models, Molecular
Protein Binding
Protein Interaction Domains and Motifs
Protein Interaction Mapping
Protein Interaction Maps
Proteomics
Receptors, G-Protein-Coupled
Signal Transduction
Structure-Activity Relationship

Paginierung

147 - 178

Datum der Veröffentlichung

2016

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2017

Titel

Adhesion GPCR-Related Protein Networks.

Ausgabe der Zeitschrift

234

Datenquelle: PubMed

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