Heart rate variability: reference values and role for clinical profile and mortality in individuals with heart failure

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Zeitschriftenaufsatz
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Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Aims</jats:title> <jats:p>To establish reference values and clinically relevant determinants for measures of heart rate variability (HRV) and to assess their relevance for clinical outcome prediction in individuals with heart failure. </jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Data from the MyoVasc study (NCT04064450; <jats:italic>N</jats:italic> = 3289), a prospective cohort on chronic heart failure with a highly standardized, 5 h examination, and Holter ECG recording were investigated. HRV markers were selected using a systematic literature screen and a data-driven approach. Reference values were determined from a healthy subsample. Clinical determinants of HRV were investigated via multivariable linear regression analyses, while their relationship with mortality was investigated by multivariable Cox regression analyses.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Holter ECG recordings were available for analysis in 1001 study participants (mean age 64.5 ± 10.5 years; female sex 35.4%). While the most frequently reported HRV markers in literature were from time and frequency domains, the data-driven approach revealed predominantly non-linear HRV measures. Age, sex, dyslipidemia, family history of myocardial infarction or stroke, peripheral artery disease, and heart failure were strongly related to HRV in multivariable models. In a follow-up period of 6.5 years, acceleration capacity [HR<jats:sub>perSD</jats:sub> 1.53 (95% CI 1.21/1.93), <jats:italic>p</jats:italic> = 0.0004], deceleration capacity [HR<jats:sub>perSD</jats:sub>: 0.70 (95% CI 0.55/0.88), <jats:italic>p</jats:italic> = 0.002], and time lag [HR<jats:sub>perSD</jats:sub> 1.22 (95% CI 1.03/1.44), <jats:italic>p</jats:italic> = 0.018] were the strongest predictors of all-cause mortality in individuals with heart failure independently of cardiovascular risk factors, comorbidities, and medication.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>HRV markers are associated with the cardiovascular clinical profile and are strong and independent predictors of survival in heart failure. This underscores clinical relevance and interventional potential for individuals with heart failure.</jats:p> </jats:sec><jats:sec> <jats:title>ClinicalTrials.gov identifier</jats:title> <jats:p>NCT04064450.</jats:p> </jats:sec>
Autoren
  • Silav Zeid
  • Gregor Buch
  • David Velmeden
  • Jakob Söhne
  • Andreas Schulz
  • Alexander Schuch
  • Sven-Oliver Tröbs
  • Marc William Heidorn
  • Felix Müller
  • Konstantin Strauch
  • Katrin Coboeken
  • Karl J Lackner
  • Tommaso Gori
  • Thomas Münzel
  • Jürgen H Prochaska
  • Philipp S Wild
DOI
10.1007/s00392-023-02248-7
eISSN
1861-0692
ISSN
1861-0684
Zeitschrift
Clinical Research in Cardiology
Sprache
en
Online publication date
2023
Status
Published online
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/s00392-023-02248-7
Datum der Datenerfassung
2023
Titel
Heart rate variability: reference values and role for clinical profile and mortality in individuals with heart failure

Datenquelle: Crossref

Andere Metadatenquellen:
Author's licence
CC-BY
Autoren
  • Silav Zeid
  • Gregor Buch
  • David Velmeden
  • Jakob Söhne
  • Andreas Schulz
  • Alexander Schuch
  • Sven-Oliver Tröbs
  • Marc William Heidorn
  • Felix Müller
  • Konstantin Strauch
  • Katrin Coboeken
  • Karl J Lackner
  • Tommaso Gori
  • Thomas Münzel
  • Jürgen H Prochaska
  • Philipp S Wild
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-H
Resource version
Published version
DOI
10.1007/s00392-023-02248-7
File(s) embargoed
false
Open access
true
ISSN
1861-0692
Zeitschrift
Clinical research in cardiology
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Datum der Veröffentlichung
2023
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/9462
Herausgeber
Springer
Datum der Datenerfassung
2023
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Zugang
Public
Titel
Heart rate variability : reference values and role for clinical profile and mortality in individuals with heart failure
Ausgabe der Zeitschrift
Version of Record (VoR)

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Datenquelle: OPENSCIENCE.UB

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