Tryptophan catabolites and depression in the general population: results from the Gutenberg Health Study

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Abstract
<jats:title>Abstract</jats:title><jats:p>Previous studies reported significantly altered tryptophan catabolite concentrations in major depression. Thus, tryptophan catabolites were considered as potential biomarkers of depression and their modulators as potential targets for psychopharmacotherapy. However, the results were based mainly on studies with small sample sizes limiting their generalizability. Against this background, we investigated the relationship of peripheral tryptophan catabolites with depression in a population-based sample with <jats:italic>n</jats:italic> = 3,389 participants (with fasting status ≥ 8 h and C-reactive protein &lt; 10 mg/L). <jats:italic>N</jats:italic> = 248 had clinically significant depression according to a PHQ-9 score of ≥ 10, <jats:italic>n</jats:italic> = 1,101 subjects had mild depressive symptoms with PHQ-9 scores between 5 and 9, and n = 2,040 had no depression. After multivariable adjustment, clinically significant depression was associated with lower kynurenine and kynurenic acid. Spearman correlation coefficients of the tryptophan catabolites with the severity of depression were very small (rho ≤ 0.080, <jats:italic>p</jats:italic> ≤ 0.015). None of the tryptophan catabolites could diagnostically separate depressed from not depressed persons. Concerning linear associations, kynurenine and kynurenic acid were associated only with the severity and the cognitive dimension of depression but not its somatic dimension. Tryptophan catabolites were not associated with persistence or recurrence of depression at the 5 year follow-up. The results replicated the association between kynurenine and kynurenic acid with depression. However, the associations were small raising doubts about their clinical utility. Findings underline the complexity of the relationships between depression and tryptophan catabolites. The search for subgroups of depression with a potentially higher impact of depression might be warranted.</jats:p>
Autoren
  • Matthias Michal
  • Andreas Schulz
  • Philipp S Wild
  • Thomas Koeck
  • Thomas Münzel
  • Alexander K Schuster
  • Konstantin Strauch
  • Karl Lackner
  • Sigurd D Süssmuth
  • Heiko G Niessen
  • Andreas Borta
  • Kelly A Allers
  • Daniela Zahn
  • Manfred E Beutel
DOI
10.1186/s12888-023-04520-6
eISSN
1471-244X
Ausgabe der Veröffentlichung
1
Zeitschrift
BMC Psychiatry
Sprache
en
Artikelnummer
27
Online publication date
2023
Status
Published online
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1186/s12888-023-04520-6
Datum der Datenerfassung
2023
Titel
Tryptophan catabolites and depression in the general population: results from the Gutenberg Health Study
Ausgabe der Zeitschrift
23

Datenquelle: Crossref

Andere Metadatenquellen:
Author's licence
CC-BY
Autoren
  • Matthias Michal
  • Andreas Schulz
  • Philipp S Wild
  • Thomas Koeck
  • Thomas Münzel
  • Alexander K Schuster
  • Konstantin Strauch
  • Karl Lackner
  • Sigurd D Süssmuth
  • Heiko G Niessen
  • Andreas Borta
  • Kelly A Allers
  • Daniela Zahn
  • Manfred E Beutel
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-G
Resource version
Published version
DOI
10.1186/s12888-023-04520-6
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft (DFG)|491381577|Open-Access-Publikationskosten 2022–2024 Universität Mainz - Universitätsmedizin
File(s) embargoed
false
Open access
true
ISSN
1471-244X
Zeitschrift
BMC psychiatry
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
27
Datum der Veröffentlichung
2023
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/9461
Herausgeber
BioMed Central
Datum der Datenerfassung
2023
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Zugang
Public
Titel
Tryptophan catabolites and depression in the general population : results from the Gutenberg Health Study
Ausgabe der Zeitschrift
23

Files

tryptophan_catabolites_and_de-20230818130311332.pdf

Datenquelle: OPENSCIENCE.UB

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