Low genetic variation is associated with low mutation rate in the giant duckweed
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Shuqing Xu
- Jessica Stapley
- Saskia Gablenz
- Justin Boyer
- Klaus J Appenroth
- K Sowjanya Sree
- Jonathan Gershenzon
- Alex Widmer
- Meret Huber
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000461757000001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1038/s41467-019-09235-5
- Externe Identifier
- Clarivate Analytics Document Solution ID: HP5XN
- PubMed Identifier: 30886148
- ISSN
- 2041-1723
- Zeitschrift
- NATURE COMMUNICATIONS
- Artikelnummer
- ARTN 1243
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Titel
- Low genetic variation is associated with low mutation rate in the giant duckweed
- Sub types
- Article
- Ausgabe der Zeitschrift
- 10
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Mutation rate and effective population size (<jats:italic>N</jats:italic><jats:sub>e</jats:sub>) jointly determine intraspecific genetic diversity, but the role of mutation rate is often ignored. Here we investigate genetic diversity, spontaneous mutation rate and<jats:italic>N</jats:italic><jats:sub>e</jats:sub>in the giant duckweed (<jats:italic>Spirodela polyrhiza</jats:italic>). Despite its large census population size, whole-genome sequencing of 68 globally sampled individuals reveals extremely low intraspecific genetic diversity. Assessed under natural conditions, the genome-wide spontaneous mutation rate is at least seven times lower than estimates made for other multicellular eukaryotes, whereas<jats:italic>N</jats:italic><jats:sub>e</jats:sub>is large. These results demonstrate that low genetic diversity can be associated with large-<jats:italic>N</jats:italic><jats:sub>e</jats:sub>species, where selection can reduce mutation rates to very low levels. This study also highlights that accurate estimates of mutation rate can help to explain seemingly unexpected patterns of genome-wide variation.</jats:p>
- Autoren
- Shuqing Xu
- Jessica Stapley
- Saskia Gablenz
- Justin Boyer
- Klaus J Appenroth
- K Sowjanya Sree
- Jonathan Gershenzon
- Alex Widmer
- Meret Huber
- DOI
- 10.1038/s41467-019-09235-5
- eISSN
- 2041-1723
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Nature Communications
- Sprache
- en
- Artikelnummer
- 1243
- Online publication date
- 2019
- Status
- Published online
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/s41467-019-09235-5
- Datum der Datenerfassung
- 2023
- Titel
- Low genetic variation is associated with low mutation rate in the giant duckweed
- Ausgabe der Zeitschrift
- 10
Datenquelle: Crossref
- Abstract
- Mutation rate and effective population size (N<sub>e</sub>) jointly determine intraspecific genetic diversity, but the role of mutation rate is often ignored. Here we investigate genetic diversity, spontaneous mutation rate and N<sub>e</sub> in the giant duckweed (Spirodela polyrhiza). Despite its large census population size, whole-genome sequencing of 68 globally sampled individuals reveals extremely low intraspecific genetic diversity. Assessed under natural conditions, the genome-wide spontaneous mutation rate is at least seven times lower than estimates made for other multicellular eukaryotes, whereas N<sub>e</sub> is large. These results demonstrate that low genetic diversity can be associated with large-N<sub>e</sub> species, where selection can reduce mutation rates to very low levels. This study also highlights that accurate estimates of mutation rate can help to explain seemingly unexpected patterns of genome-wide variation.
- Addresses
- Institute for Evolution and Biodiversity, University of Münster, Hüfferstrasse 1, 48149, Münster, Germany. shuqing.xu@uni-muenster.de.
- Autoren
- Shuqing Xu
- Jessica Stapley
- Saskia Gablenz
- Justin Boyer
- Klaus J Appenroth
- K Sowjanya Sree
- Jonathan Gershenzon
- Alex Widmer
- Meret Huber
- DOI
- 10.1038/s41467-019-09235-5
- eISSN
- 2041-1723
- Externe Identifier
- PubMed Identifier: 30886148
- PubMed Central ID: PMC6423293
- Open access
- true
- ISSN
- 2041-1723
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Nature communications
- Schlüsselwörter
- Araceae
- DNA Mutational Analysis
- Genome, Plant
- Africa
- Americas
- Asia
- Europe
- Genetic Variation
- Phylogeography
- Mutation Rate
- Plant Dispersal
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2019
- Open access status
- Open Access
- Paginierung
- 1243
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2019
- Titel
- Low genetic variation is associated with low mutation rate in the giant duckweed.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 10
Files
https://www.nature.com/articles/s41467-019-09235-5.pdf https://europepmc.org/articles/PMC6423293?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Mutation rate and effective population size (Ne) jointly determine intraspecific genetic diversity, but the role of mutation rate is often ignored. Here we investigate genetic diversity, spontaneous mutation rate and Ne in the giant duckweed (Spirodela polyrhiza). Despite its large census population size, whole-genome sequencing of 68 globally sampled individuals reveals extremely low intraspecific genetic diversity. Assessed under natural conditions, the genome-wide spontaneous mutation rate is at least seven times lower than estimates made for other multicellular eukaryotes, whereas Ne is large. These results demonstrate that low genetic diversity can be associated with large-Ne species, where selection can reduce mutation rates to very low levels. This study also highlights that accurate estimates of mutation rate can help to explain seemingly unexpected patterns of genome-wide variation.
- Date of acceptance
- 2019
- Autoren
- Shuqing Xu
- Jessica Stapley
- Saskia Gablenz
- Justin Boyer
- Klaus J Appenroth
- K Sowjanya Sree
- Jonathan Gershenzon
- Alex Widmer
- Meret Huber
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/30886148
- DOI
- 10.1038/s41467-019-09235-5
- eISSN
- 2041-1723
- Externe Identifier
- PubMed Central ID: PMC6423293
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Nat Commun
- Schlüsselwörter
- Africa
- Americas
- Araceae
- Asia
- DNA Mutational Analysis
- Europe
- Genetic Variation
- Genome, Plant
- Mutation Rate
- Phylogeography
- Plant Dispersal
- Sprache
- eng
- Country
- England
- Paginierung
- 1243
- PII
- 10.1038/s41467-019-09235-5
- Datum der Veröffentlichung
- 2019
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2019
- Titel
- Low genetic variation is associated with low mutation rate in the giant duckweed.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 10
Datenquelle: PubMed
- Beziehungen:
- Eigentum von