No DDRama at chromosome ends: TRF2 takes centre stage
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Sascha Feuerhahn
- Liuh-yow Chen
- Brian Luke
- Antonio Porro
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000354143900006&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.tibs.2015.03.003
- eISSN
- 1362-4326
- Externe Identifier
- Clarivate Analytics Document Solution ID: CH6JW
- PubMed Identifier: 25845889
- ISSN
- 0968-0004
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- TRENDS IN BIOCHEMICAL SCIENCES
- Schlüsselwörter
- TRF2
- telomeres
- DNA damage response
- chromatin
- TERRA
- t-loops
- Paginierung
- 275 - 285
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Titel
- No DDRama at chromosome ends: TRF2 takes centre stage
- Sub types
- Review
- Ausgabe der Zeitschrift
- 40
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Sascha Feuerhahn
- Liuh-yow Chen
- Brian Luke
- Antonio Porro
- DOI
- 10.1016/j.tibs.2015.03.003
- ISSN
- 0968-0004
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Trends in Biochemical Sciences
- Sprache
- en
- Paginierung
- 275 - 285
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.tibs.2015.03.003
- Datum der Datenerfassung
- 2019
- Titel
- No DDRama at chromosome ends: TRF2 takes centre stage
- Ausgabe der Zeitschrift
- 40
Datenquelle: Crossref
- Abstract
- Telomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence fusion reactions, by limiting inappropriate double-strand break (DSB) repair and processing activities at eukaryotic chromosome ends. A telomere-specific protein complex, termed shelterin, has a crucial function in safeguarding and securing telomere integrity. Within this complex, TRF2 has emerged as the key player, dictating different states of telomere protection during the replicative lifespan of a cell. How TRF2 prevents activation of DSB repair activities at functional telomeres has now been extensively investigated. In this review we aim at exploring the complex and multi-faceted mechanisms underlying the TRF2-mediated protection of eukaryotic chromosome ends.
- Addresses
- Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland.
- Autoren
- Sascha Feuerhahn
- Liuh-yow Chen
- Brian Luke
- Antonio Porro
- DOI
- 10.1016/j.tibs.2015.03.003
- Externe Identifier
- PubMed Identifier: 25845889
- Open access
- false
- ISSN
- 0968-0004
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Trends in biochemical sciences
- Schlüsselwörter
- Chromosomes
- Chromatin
- Telomere
- Animals
- Humans
- DNA Damage
- Telomeric Repeat Binding Protein 2
- DNA Repair
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2015
- Paginierung
- 275 - 285
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum der Datenerfassung
- 2015
- Titel
- No DDRama at chromosome ends: TRF2 takes centre stage.
- Sub types
- Research Support, Non-U.S. Gov't
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 40
Datenquelle: Europe PubMed Central
- Abstract
- Telomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence fusion reactions, by limiting inappropriate double-strand break (DSB) repair and processing activities at eukaryotic chromosome ends. A telomere-specific protein complex, termed shelterin, has a crucial function in safeguarding and securing telomere integrity. Within this complex, TRF2 has emerged as the key player, dictating different states of telomere protection during the replicative lifespan of a cell. How TRF2 prevents activation of DSB repair activities at functional telomeres has now been extensively investigated. In this review we aim at exploring the complex and multi-faceted mechanisms underlying the TRF2-mediated protection of eukaryotic chromosome ends.
- Date of acceptance
- 2015
- Autoren
- Sascha Feuerhahn
- Liuh-yow Chen
- Brian Luke
- Antonio Porro
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/25845889
- DOI
- 10.1016/j.tibs.2015.03.003
- ISSN
- 0968-0004
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Trends Biochem Sci
- Schlüsselwörter
- DNA damage response
- TERRA
- TRF2
- chromatin
- t-loops
- telomeres
- Animals
- Chromatin
- Chromosomes
- DNA Damage
- DNA Repair
- Humans
- Telomere
- Telomeric Repeat Binding Protein 2
- Sprache
- eng
- Country
- England
- Paginierung
- 275 - 285
- PII
- S0968-0004(15)00041-9
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2015
- Titel
- No DDRama at chromosome ends: TRF2 takes centre stage.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
- Ausgabe der Zeitschrift
- 40
Datenquelle: PubMed
- Abstract
- Telomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence fusion reactions, by limiting inappropriate double-strand break (DSB) repair and processing activities at eukaryotic chromosome ends. A telomere-specific protein complex, termed shelterin, has a crucial function in safeguarding and securing telomere integrity. Within this complex, TRF2 has emerged as the key player, dictating different states of telomere protection during the replicative lifespan of a cell. How TRF2 prevents activation of DSB repair activities at functional telomeres has now been extensively investigated. In this review we aim at exploring the complex and multi-faceted mechanisms underlying the TRF2-mediated protection of eukaryotic chromosome ends.
- Autoren
- Sascha Feuerhahn
- Liuh-yow Chen
- Brian Luke
- Antonio Porro
- DOI
- 10.1016/j.tibs.2015.03.003
- ISSN
- 0968-0004
- Zeitschrift
- Trends in biochemical sciences
- Notes
- keywords: Animals;Chromatin/metabolism;Chromosomes/metabolism;DNA Damage/genetics/physiology;DNA Repair/genetics/physiology;Humans;Telomere/genetics/metabolism;Telomeric Repeat Binding Protein 2/genetics/metabolism
- Artikelnummer
- 5
- Paginierung
- 275 - 285
- Datum der Veröffentlichung
- 2015
- Datum der Datenerfassung
- 2023
- Titel
- No DDRama at chromosome ends: TRF2 takes centre stage
- Sub types
- article
- Ausgabe der Zeitschrift
- 40
Datenquelle: Manual
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