Evolutionary Study of Protein Short Tandem Repeats in Protein Families
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Pablo Mier
- Miguel A Andrade-Navarro
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:001038046200001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/biom13071116
- eISSN
- 2218-273X
- Externe Identifier
- Clarivate Analytics Document Solution ID: N6JH3
- PubMed Identifier: 37509152
- Ausgabe der Veröffentlichung
- 7
- Zeitschrift
- BIOMOLECULES
- Schlüsselwörter
- low complexity regions
- repeats
- protein sequence analysis
- Artikelnummer
- ARTN 1116
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Titel
- Evolutionary Study of Protein Short Tandem Repeats in Protein Families
- Sub types
- Article
- Ausgabe der Zeitschrift
- 13
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>Tandem repeats in proteins are patterns of residues repeated directly adjacent to each other. The evolution of these repeats can be assessed by using groups of homologous sequences, which can help pointing to events of unit duplication or deletion. High pressure in a protein family for variation of a given type of repeat might point to their function. Here, we propose the analysis of protein families to calculate protein short tandem repeats (pSTRs) in each protein sequence and assess their variability within the family in terms of number of units. To facilitate this analysis, we developed the pSTR tool, a method to analyze the evolution of protein short tandem repeats in a given protein family by pairwise comparisons between evolutionarily related protein sequences. We evaluated pSTR unit number variation in protein families of 12 complete metazoan proteomes. We hypothesize that families with more dynamic ensembles of repeats could reflect particular roles of these repeats in processes that require more adaptability.</jats:p>
- Autoren
- Pablo Mier
- Miguel A Andrade-Navarro
- DOI
- 10.3390/biom13071116
- eISSN
- 2218-273X
- Ausgabe der Veröffentlichung
- 7
- Zeitschrift
- Biomolecules
- Sprache
- en
- Online publication date
- 2023
- Paginierung
- 1116 - 1116
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/biom13071116
- Datum der Datenerfassung
- 2023
- Titel
- Evolutionary Study of Protein Short Tandem Repeats in Protein Families
- Ausgabe der Zeitschrift
- 13
Datenquelle: Crossref
- Abstract
- Tandem repeats in proteins are patterns of residues repeated directly adjacent to each other. The evolution of these repeats can be assessed by using groups of homologous sequences, which can help pointing to events of unit duplication or deletion. High pressure in a protein family for variation of a given type of repeat might point to their function. Here, we propose the analysis of protein families to calculate protein short tandem repeats (pSTRs) in each protein sequence and assess their variability within the family in terms of number of units. To facilitate this analysis, we developed the pSTR tool, a method to analyze the evolution of protein short tandem repeats in a given protein family by pairwise comparisons between evolutionarily related protein sequences. We evaluated pSTR unit number variation in protein families of 12 complete metazoan proteomes. We hypothesize that families with more dynamic ensembles of repeats could reflect particular roles of these repeats in processes that require more adaptability.
- Addresses
- Faculty of Biology, Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
- Autoren
- Pablo Mier
- Miguel A Andrade-Navarro
- DOI
- 10.3390/biom13071116
- eISSN
- 2218-273X
- Externe Identifier
- PubMed Identifier: 37509152
- PubMed Central ID: PMC10377733
- Open access
- true
- ISSN
- 2218-273X
- Ausgabe der Veröffentlichung
- 7
- Zeitschrift
- Biomolecules
- Schlüsselwörter
- Animals
- Proteome
- Evolution, Molecular
- Amino Acid Sequence
- Microsatellite Repeats
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2023
- Open access status
- Open Access
- Paginierung
- 1116
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2023
- Titel
- Evolutionary Study of Protein Short Tandem Repeats in Protein Families.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 13
Files
https://europepmc.org/articles/PMC10377733?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Tandem repeats in proteins are patterns of residues repeated directly adjacent to each other. The evolution of these repeats can be assessed by using groups of homologous sequences, which can help pointing to events of unit duplication or deletion. High pressure in a protein family for variation of a given type of repeat might point to their function. Here, we propose the analysis of protein families to calculate protein short tandem repeats (pSTRs) in each protein sequence and assess their variability within the family in terms of number of units. To facilitate this analysis, we developed the pSTR tool, a method to analyze the evolution of protein short tandem repeats in a given protein family by pairwise comparisons between evolutionarily related protein sequences. We evaluated pSTR unit number variation in protein families of 12 complete metazoan proteomes. We hypothesize that families with more dynamic ensembles of repeats could reflect particular roles of these repeats in processes that require more adaptability.
- Date of acceptance
- 2023
- Autoren
- Pablo Mier
- Miguel A Andrade-Navarro
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/37509152
- DOI
- 10.3390/biom13071116
- eISSN
- 2218-273X
- Externe Identifier
- PubMed Central ID: PMC10377733
- Ausgabe der Veröffentlichung
- 7
- Zeitschrift
- Biomolecules
- Schlüsselwörter
- low complexity regions
- protein sequence analysis
- repeats
- Animals
- Amino Acid Sequence
- Proteome
- Microsatellite Repeats
- Evolution, Molecular
- Sprache
- eng
- Country
- Switzerland
- PII
- biom13071116
- Datum der Veröffentlichung
- 2023
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2023
- Titel
- Evolutionary Study of Protein Short Tandem Repeats in Protein Families.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 13
Datenquelle: PubMed
- Beziehungen:
- Eigentum von