Behavioral treatment for migraine prophylaxis in adults: Moderator analysis of a randomized controlled trial

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Timo Klan
  • Charly Gaul
  • Eva Liesering-Latta
  • Michael Witthoeft
  • Severin Hennemann
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:001021696900009&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1177/03331024231178237
eISSN
1468-2982
Externe Identifier
  • Clarivate Analytics Document Solution ID: L2OF6
  • PubMed Identifier: 37291853
ISSN
0333-1024
Ausgabe der Veröffentlichung
6
Zeitschrift
CEPHALALGIA
Schlüsselwörter
  • Migraine
  • prophylaxis
  • randomized controlled trial
  • behavioral treatment
  • moderators
  • therapeutic indication
Artikelnummer
ARTN 03331024231178237
Datum der Veröffentlichung
2023
Status
Published
Titel
Behavioral treatment for migraine prophylaxis in adults: Moderator analysis of a randomized controlled trial
Sub types
  • Article
Ausgabe der Zeitschrift
43

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:sec><jats:title>Background</jats:title><jats:p> While growing evidence suggests the efficacy of various behavioral approaches to the preventive treatment of migraine, it remains largely unclear which behavioral interventions are indicated for which type of patient. This exploratory study aimed to identify moderators for the outcome between migraine-specific cognitive-behavioral therapy and relaxation training. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> In this secondary analysis of an open-label randomized controlled trial, the data of N  =  77 adults (completer sample) with migraine (mean age = 47.4, SD = 12.2, 88% female), who were allocated to either migraine-specific cognitive-behavioral therapy or relaxation training, was examined. Outcome was the frequency of headache days at the 12-month follow-up. We analyzed baseline demographic or clinical characteristics and headache-specific variables (disability, emotional distress, trigger sensitivity and avoidance, pain acceptance, self-efficacy) as candidate moderators. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Higher headache-related disability (assessed via the Headache Impact Test, HIT-6, B = –0.41 [95% CI: –0.85 to –0.10], p = .047), higher anxiety (assessed via the subscale Anxiety of the Depression, Anxiety and Stress scales, DASS-A, B = –0.66 [95% CI: –1.27 to –0.02], p = .056), and the presence of a comorbid mental disorder ( B = –4.98, [95% CI: –9.42 to –0.29], p = .053), moderated the outcome in favor of migraine-specific cognitive-behavioral therapy. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Our findings contribute to an individualized treatment selection and suggest that preference for complex behavioral treatment (migraine-specific cognitive-behavioral therapy) should be given to patients with high headache-related disability, increased anxiety, or a comorbid mental disorder. Study Registration: Original study registered in the German Clinical Trials Register ( https://drks.de/search/de ; DRKS-ID: DRKS00011111). </jats:p></jats:sec>
Autoren
  • Timo Klan
  • Charly Gaul
  • Eva Liesering-Latta
  • Michael Witthöft
  • Severin Hennemann
DOI
10.1177/03331024231178237
eISSN
1468-2982
ISSN
0333-1024
Ausgabe der Veröffentlichung
6
Zeitschrift
Cephalalgia
Sprache
en
Online publication date
2023
Paginierung
033310242311782 - 033310242311782
Datum der Veröffentlichung
2023
Status
Published
Herausgeber
SAGE Publications
Herausgeber URL
http://dx.doi.org/10.1177/03331024231178237
Datum der Datenerfassung
2023
Titel
Behavioral treatment for migraine prophylaxis in adults: Moderator analysis of a randomized controlled trial
Ausgabe der Zeitschrift
43

Datenquelle: Crossref

Abstract
<h4>Background</h4>While growing evidence suggests the efficacy of various behavioral approaches to the preventive treatment of migraine, it remains largely unclear which behavioral interventions are indicated for which type of patient. This exploratory study aimed to identify moderators for the outcome between migraine-specific cognitive-behavioral therapy and relaxation training.<h4>Methods</h4>In this secondary analysis of an open-label randomized controlled trial, the data of <i>N</i>  =  77 adults (completer sample) with migraine (mean age = 47.4, <i>SD</i> = 12.2, 88% female), who were allocated to either migraine-specific cognitive-behavioral therapy or relaxation training, was examined. Outcome was the frequency of headache days at the 12-month follow-up. We analyzed baseline demographic or clinical characteristics and headache-specific variables (disability, emotional distress, trigger sensitivity and avoidance, pain acceptance, self-efficacy) as candidate moderators.<h4>Results</h4>Higher headache-related disability (assessed via the Headache Impact Test, HIT-6, <i>B</i> = -0.41 [95% CI: -0.85 to -0.10], <i>p</i> = .047), higher anxiety (assessed via the subscale Anxiety of the Depression, Anxiety and Stress scales, DASS-A, <i>B</i> = -0.66 [95% CI: -1.27 to -0.02], <i>p</i> = .056), and the presence of a comorbid mental disorder (<i>B</i> = -4.98, [95% CI: -9.42 to -0.29], <i>p</i> = .053), moderated the outcome in favor of migraine-specific cognitive-behavioral therapy.<h4>Conclusion</h4>Our findings contribute to an individualized treatment selection and suggest that preference for complex behavioral treatment (migraine-specific cognitive-behavioral therapy) should be given to patients with high headache-related disability, increased anxiety, or a comorbid mental disorder.<b>Study Registration:</b> Original study registered in the German Clinical Trials Register (https://drks.de/search/de; DRKS-ID: DRKS00011111).
Addresses
  • Department of Psychology, Johannes Gutenberg University of Mainz, Mainz, Germany.
Autoren
  • Timo Klan
  • Charly Gaul
  • Eva Liesering-Latta
  • Michael Witthöft
  • Severin Hennemann
DOI
10.1177/03331024231178237
eISSN
1468-2982
Externe Identifier
  • PubMed Identifier: 37291853
Funding acknowledgements
  • The RCT was funded by the German Migraine and Headache Society (DMKG) and by internal funds (Department of Psychology, Johannes Gutenberg University of Mainz).:
Open access
false
ISSN
0333-1024
Ausgabe der Veröffentlichung
6
Zeitschrift
Cephalalgia : an international journal of headache
Schlüsselwörter
  • Humans
  • Pain
  • Headache
  • Treatment Outcome
  • Adult
  • Middle Aged
  • Female
  • Male
  • Migraine Disorders
  • Cognitive Behavioral Therapy
Sprache
eng
Medium
Print
Paginierung
3331024231178237
Datum der Veröffentlichung
2023
Status
Published
Publisher licence
CC BY-NC
Datum der Datenerfassung
2023
Titel
Behavioral treatment for migraine prophylaxis in adults: Moderator analysis of a randomized controlled trial.
Sub types
  • Randomized Controlled Trial
  • Journal Article
Ausgabe der Zeitschrift
43

Datenquelle: Europe PubMed Central

Abstract
BACKGROUND: While growing evidence suggests the efficacy of various behavioral approaches to the preventive treatment of migraine, it remains largely unclear which behavioral interventions are indicated for which type of patient. This exploratory study aimed to identify moderators for the outcome between migraine-specific cognitive-behavioral therapy and relaxation training. METHODS: In this secondary analysis of an open-label randomized controlled trial, the data of N  =  77 adults (completer sample) with migraine (mean age = 47.4, SD = 12.2, 88% female), who were allocated to either migraine-specific cognitive-behavioral therapy or relaxation training, was examined. Outcome was the frequency of headache days at the 12-month follow-up. We analyzed baseline demographic or clinical characteristics and headache-specific variables (disability, emotional distress, trigger sensitivity and avoidance, pain acceptance, self-efficacy) as candidate moderators. RESULTS: Higher headache-related disability (assessed via the Headache Impact Test, HIT-6, B = -0.41 [95% CI: -0.85 to -0.10], p = .047), higher anxiety (assessed via the subscale Anxiety of the Depression, Anxiety and Stress scales, DASS-A, B = -0.66 [95% CI: -1.27 to -0.02], p = .056), and the presence of a comorbid mental disorder (B = -4.98, [95% CI: -9.42 to -0.29], p = .053), moderated the outcome in favor of migraine-specific cognitive-behavioral therapy. CONCLUSION: Our findings contribute to an individualized treatment selection and suggest that preference for complex behavioral treatment (migraine-specific cognitive-behavioral therapy) should be given to patients with high headache-related disability, increased anxiety, or a comorbid mental disorder.Study Registration: Original study registered in the German Clinical Trials Register (https://drks.de/search/de; DRKS-ID: DRKS00011111).
Autoren
  • Timo Klan
  • Charly Gaul
  • Eva Liesering-Latta
  • Michael Witthöft
  • Severin Hennemann
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/37291853
DOI
10.1177/03331024231178237
eISSN
1468-2982
Ausgabe der Veröffentlichung
6
Zeitschrift
Cephalalgia
Schlüsselwörter
  • Migraine
  • behavioral treatment
  • moderators
  • prophylaxis
  • randomized controlled trial
  • therapeutic indication
  • Humans
  • Adult
  • Female
  • Middle Aged
  • Male
  • Treatment Outcome
  • Headache
  • Migraine Disorders
  • Cognitive Behavioral Therapy
  • Pain
Sprache
eng
Country
England
Paginierung
3331024231178237
Datum der Veröffentlichung
2023
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Titel
Behavioral treatment for migraine prophylaxis in adults: Moderator analysis of a randomized controlled trial.
Sub types
  • Randomized Controlled Trial
  • Journal Article
Ausgabe der Zeitschrift
43

Datenquelle: PubMed

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