Physiology of Mycobacteria
- Publikationstyp:
- Kapitel
- Metadaten:
-
- Autoren
- Gregory M Cook
- Michael Berney
- Susanne Gebhard
- Matthias Heinemann
- Robert A Cox
- Olga Danilchanka
- Michael Niederweis
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000301674400002&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/S0065-2911(09)05502-7
- ISBN-13
- 978-0-12-374790-7
- Paginierung
- 81 - 182
- Buchtitel
- ADVANCES IN MICROBIAL PHYSIOLOGY, VOL 55
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Titel
- Physiology of Mycobacteria
- Ausgabe der Zeitschrift
- 55
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Gregory M Cook
- Michael Berney
- Susanne Gebhard
- Matthias Heinemann
- Robert A Cox
- Olga Danilchanka
- Michael Niederweis
- DOI
- 10.1016/s0065-2911(09)05502-7
- ISBN-13
- 9780123747907
- Paginierung
- 81 - 319
- Buchtitel
- Advances in Microbial Physiology
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Herausgeber
- Elsevier
- Herausgeber URL
- http://dx.doi.org/10.1016/s0065-2911(09)05502-7
- Datum der Datenerfassung
- 2021
- Titel
- Physiology of Mycobacteria
Datenquelle: Crossref
- Abstract
- Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has achieved a spread in the human population that is unmatched by any other bacterial pathogen. The success of M. tuberculosis as a pathogen can be attributed to its extraordinary stealth and capacity to adapt to environmental changes throughout the course of infection. These changes include: nutrient deprivation, hypoxia, various exogenous stress conditions and, in the case of the pathogenic species, the intraphagosomal environment. Knowledge of the physiology of M. tuberculosis during this process has been limited by the slow growth of the bacterium in the laboratory and other technical problems such as cell aggregation. Advances in genomics and molecular methods to analyze the M. tuberculosis genome have revealed that adaptive changes are mediated by complex regulatory networks and signals, resulting in temporal gene expression coupled to metabolic and energetic changes. An important goal for bacterial physiologists will be to elucidate the physiology of M. tuberculosis during the transition between the diverse conditions encountered by M. tuberculosis. This review covers the growth of the mycobacterial cell and how environmental stimuli are sensed by this bacterium. Adaptation to different environments is described from the viewpoint of nutrient acquisition, energy generation, and regulation. To gain quantitative understanding of mycobacterial physiology will require a systems biology approach and recent efforts in this area are discussed.
- Addresses
- Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
- Autoren
- Gregory M Cook
- Michael Berney
- Susanne Gebhard
- Matthias Heinemann
- Robert A Cox
- Olga Danilchanka
- Michael Niederweis
- DOI
- 10.1016/s0065-2911(09)05502-7
- Funding Acknowledgements
- NIAID NIH HHS: R01 AI063432
- NIAID NIH HHS: AI063432
- Open access
- false
- Schlüsselwörter
- Humans
- Mycobacterium tuberculosis
- Signal Transduction
- Gene Expression Regulation, Bacterial
- Energy Metabolism
- Stress, Physiological
- Bacterial Physiological Phenomena
- Medium
- Paginierung
- 81 - 319
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Datum der Datenerfassung
- 2009
- Titel
- Physiology of mycobacteria.
- Ausgabe der Zeitschrift
- 55
Files
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19573696/pdf/?tool=EBI https://europepmc.org/articles/PMC3728839?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has achieved a spread in the human population that is unmatched by any other bacterial pathogen. The success of M. tuberculosis as a pathogen can be attributed to its extraordinary stealth and capacity to adapt to environmental changes throughout the course of infection. These changes include: nutrient deprivation, hypoxia, various exogenous stress conditions and, in the case of the pathogenic species, the intraphagosomal environment. Knowledge of the physiology of M. tuberculosis during this process has been limited by the slow growth of the bacterium in the laboratory and other technical problems such as cell aggregation. Advances in genomics and molecular methods to analyze the M. tuberculosis genome have revealed that adaptive changes are mediated by complex regulatory networks and signals, resulting in temporal gene expression coupled to metabolic and energetic changes. An important goal for bacterial physiologists will be to elucidate the physiology of M. tuberculosis during the transition between the diverse conditions encountered by M. tuberculosis. This review covers the growth of the mycobacterial cell and how environmental stimuli are sensed by this bacterium. Adaptation to different environments is described from the viewpoint of nutrient acquisition, energy generation, and regulation. To gain quantitative understanding of mycobacterial physiology will require a systems biology approach and recent efforts in this area are discussed.
- Autoren
- Gregory M Cook
- Michael Berney
- Susanne Gebhard
- Matthias Heinemann
- Robert A Cox
- Olga Danilchanka
- Michael Niederweis
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/19573696
- DOI
- 10.1016/S0065-2911(09)05502-7
- Funding Acknowledgements
- NIAID NIH HHS: R01 AI063432
- NIAID NIH HHS: AI063432
- Schlüsselwörter
- Bacterial Physiological Phenomena
- Energy Metabolism
- Gene Expression Regulation, Bacterial
- Humans
- Mycobacterium tuberculosis
- Signal Transduction
- Stress, Physiological
- Paginierung
- 81 - 319
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2009
- Titel
- Physiology of mycobacteria.
- Ausgabe der Zeitschrift
- 55
Datenquelle: PubMed
- Beziehungen:
- Eigentum von