Reverse cardiac remodeling in patients undergoing combination therapy of transcatheter mitral valve repair

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Abstract
<jats:sec><jats:title>Aims</jats:title><jats:p>For patients with severe mitral valve regurgitation (MR), different kinds of transcatheter mitral valve repair (TMVr) exist, targeting the leaflets, annulus, and chordae. The concomitant combination (COMBO) therapy of TMVrs is rarely used as treatment, and there are very few publications about this therapeutic strategy. We evaluated the effect of COMBO-TMVr on the cardiac left chambers and clinical data, including survival.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We included 35 patients at high risk who underwent concomitant sequential transcatheter mitral valve edge-to-edge repair (M-TEER) and another TMVr for severe MR in our hospital between March 2015 and April 2018. Of these, 13 had adequate follow-up transthoracic echocardiography (TTE) up to around 1 year after the procedure.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Survival for all patients was 83% at 1 year, 71% at 2 years, and 63% at 3 years, respectively. In the 13 patients with adequate TTE follow-up, M-TEER plus either Cardioband (<jats:italic>n</jats:italic> = 4), Carillon Mitral Contour System (<jats:italic>n</jats:italic> = 7), or Neochord (<jats:italic>n</jats:italic> = 2) were used, respectively. Ten patients had secondary, and three patients primary MR. After 1 year, changes [median (Q1, Q3)] of left ventricular (LV) end-systolic diameter of −9.9 cm (−11.1, 0.4), LV end-diastolic diameter of −3.3 cm (−8.5, 0.0), LV end-systolic volume (LVESV) of −17.4 mL (−32.6, −0.4), LV end-diastolic volume (LVEDV) of −13.5 mL (−15.9, −3.2), LV mass of −19.5 g (−24.2, −7.6), and left atrial volume (LAV) index (LAVi) of −16.4 mL (−23.3, −11.3) were observed. A significant reduction was also seen in the change ratios of LVESV, LVEDV, LV mass, and LAVi, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>We found that COMBO therapy of TMVr seems feasible and may support reverse remodeling of left cardiac chambers during 1 year after the procedure in a cohort of patients at high risk.</jats:p></jats:sec>
Autoren
  • Hiroaki Yokoyama
  • Tobias Friedrich Ruf
  • Martin Geyer
  • Alexander R Tamm
  • Jaqueline Grace Da Rocha E Silva
  • Theresa Ann Maria Gößler
  • Julia Zirbs
  • Ben Schwidtal
  • Thomas Münzel
  • Ralph Stephan von Bardeleben
DOI
10.3389/fcvm.2023.1029103
eISSN
2297-055X
Zeitschrift
Frontiers in Cardiovascular Medicine
Online publication date
2023
Status
Published online
Herausgeber
Frontiers Media SA
Herausgeber URL
http://dx.doi.org/10.3389/fcvm.2023.1029103
Datum der Datenerfassung
2023
Titel
Reverse cardiac remodeling in patients undergoing combination therapy of transcatheter mitral valve repair
Ausgabe der Zeitschrift
10

Datenquelle: Crossref

Andere Metadatenquellen:
Author's licence
CC-BY
Autoren
  • Hiroaki Yokoyama
  • Tobias Friedrich Ruf
  • Martin Geyer
  • Alexander R Tamm
  • Jaqueline Grace da Rocha e Silva
  • Theresa Ann Maria Gößler
  • Julia Zirbs
  • Ben Schwidtal
  • Thomas Münzel
  • Ralph Stephan von Bardeleben
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-G
Resource version
Published version
DOI
10.3389/fcvm.2023.1029103
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft (DFG)|491381577|Open-Access-Publikationskosten 2022–2024 Universität Mainz - Universitätsmedizin
File(s) embargoed
false
Open access
true
ISSN
2297-055X
Zeitschrift
Frontiers in cardiovascular medicine
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
1029103
Datum der Veröffentlichung
2023
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/9133
Herausgeber
Frontiers Media
Datum der Datenerfassung
2023
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Zugang
Public
Titel
Reverse cardiac remodeling in patients undergoing combination therapy of transcatheter mitral valve repair
Ausgabe der Zeitschrift
10

Files

reverse_cardiac_remodeling_in-20230523151351689.pdf

Datenquelle: OPENSCIENCE.UB

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