Targeted Repolarization of Tumor-Associated Macrophages via Imidazoquinoline-Linked Nanobodies
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Evangelia Bolli
- Maximilian Scherger
- Sana M Arnouk
- Ana Rita Pombo Antunes
- David Strassburger
- Moritz Urschbach
- Judith Stickdorn
- Karen De Vlaminck
- Kiavash Movahedi
- Hans Joachim Rader
- Sophie Hernot
- Pol Besenius
- Jo A Van Ginderachter
- Lutz Nuhn
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000626161500001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1002/advs.202004574
- eISSN
- 2198-3844
- Externe Identifier
- Clarivate Analytics Document Solution ID: SE1IO
- PubMed Identifier: 34026453
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- ADVANCED SCIENCE
- Schlüsselwörter
- cancer immunotherapy
- drug delivery
- M2 macrophages
- nanobodies
- repolarization
- TLR 7
- 8 agonist
- tumor associated macrophages
- Artikelnummer
- ARTN 2004574
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Targeted Repolarization of Tumor-Associated Macrophages via Imidazoquinoline-Linked Nanobodies
- Sub types
- Article
- Ausgabe der Zeitschrift
- 8
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Tumor‐associated macrophages (TAMs) promote the immune suppressive microenvironment inside tumors and are, therefore, considered as a promising target for the next generation of cancer immunotherapies. To repolarize their phenotype into a tumoricidal state, the Toll‐like receptor 7/8 agonist imidazoquinoline IMDQ is site‐specifically and quantitatively coupled to single chain antibody fragments, so‐called nanobodies, targeting the macrophage mannose receptor (MMR) on TAMs. Intravenous injection of these conjugates result in a tumor‐ and cell‐specific delivery of IMDQ into MMR<jats:sup>high</jats:sup> TAMs, causing a significant decline in tumor growth. This is accompanied by a repolarization of TAMs towards a pro‐inflammatory phenotype and an increase in anti‐tumor T cell responses. Therefore, the therapeutic benefit of such nanobody‐drug conjugates may pave the road towards effective macrophage re‐educating cancer immunotherapies.</jats:p>
- Autoren
- Evangelia Bolli
- Maximilian Scherger
- Sana M Arnouk
- Ana Rita Pombo Antunes
- David Straßburger
- Moritz Urschbach
- Judith Stickdorn
- Karen De Vlaminck
- Kiavash Movahedi
- Hans Joachim Räder
- Sophie Hernot
- Pol Besenius
- Jo A Van Ginderachter
- Lutz Nuhn
- DOI
- 10.1002/advs.202004574
- eISSN
- 2198-3844
- ISSN
- 2198-3844
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Advanced Science
- Sprache
- en
- Online publication date
- 2021
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1002/advs.202004574
- Datum der Datenerfassung
- 2023
- Titel
- Targeted Repolarization of Tumor‐Associated Macrophages via Imidazoquinoline‐Linked Nanobodies
- Ausgabe der Zeitschrift
- 8
Datenquelle: Crossref
- Abstract
- Tumor-associated macrophages (TAMs) promote the immune suppressive microenvironment inside tumors and are, therefore, considered as a promising target for the next generation of cancer immunotherapies. To repolarize their phenotype into a tumoricidal state, the Toll-like receptor 7/8 agonist imidazoquinoline IMDQ is site-specifically and quantitatively coupled to single chain antibody fragments, so-called nanobodies, targeting the macrophage mannose receptor (MMR) on TAMs. Intravenous injection of these conjugates result in a tumor- and cell-specific delivery of IMDQ into MMR<sup>high</sup> TAMs, causing a significant decline in tumor growth. This is accompanied by a repolarization of TAMs towards a pro-inflammatory phenotype and an increase in anti-tumor T cell responses. Therefore, the therapeutic benefit of such nanobody-drug conjugates may pave the road towards effective macrophage re-educating cancer immunotherapies.
- Addresses
- Lab of Cellular and Molecular Immunology Vrije Universiteit Brussel Pleinlaan 2 Brussels 1050 Belgium.
- Autoren
- Evangelia Bolli
- Maximilian Scherger
- Sana M Arnouk
- Ana Rita Pombo Antunes
- David Straßburger
- Moritz Urschbach
- Judith Stickdorn
- Karen De Vlaminck
- Kiavash Movahedi
- Hans Joachim Räder
- Sophie Hernot
- Pol Besenius
- Jo A Van Ginderachter
- Lutz Nuhn
- DOI
- 10.1002/advs.202004574
- eISSN
- 2198-3844
- Externe Identifier
- PubMed Identifier: 34026453
- PubMed Central ID: PMC8132149
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft: SFB1066
- Kom op tegen Kanker:
- Open access
- true
- ISSN
- 2198-3844
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Advanced science (Weinheim, Baden-Wurttemberg, Germany)
- Schlüsselwörter
- Animals
- Mice, Inbred C57BL
- Mice, Knockout
- Mice
- Lung Neoplasms
- Disease Models, Animal
- Imidazoles
- Quinolines
- Membrane Glycoproteins
- Toll-Like Receptor 7
- Toll-Like Receptor 6
- Tumor Microenvironment
- Single-Domain Antibodies
- Tumor-Associated Macrophages
- Mannose Receptor
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2021
- Open access status
- Open Access
- Paginierung
- 2004574
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2021
- Titel
- Targeted Repolarization of Tumor-Associated Macrophages via Imidazoquinoline-Linked Nanobodies.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 8
Files
https://biblio.vub.ac.be/vubirfiles/70534994/advs.202004574.pdf https://europepmc.org/articles/PMC8132149?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Tumor-associated macrophages (TAMs) promote the immune suppressive microenvironment inside tumors and are, therefore, considered as a promising target for the next generation of cancer immunotherapies. To repolarize their phenotype into a tumoricidal state, the Toll-like receptor 7/8 agonist imidazoquinoline IMDQ is site-specifically and quantitatively coupled to single chain antibody fragments, so-called nanobodies, targeting the macrophage mannose receptor (MMR) on TAMs. Intravenous injection of these conjugates result in a tumor- and cell-specific delivery of IMDQ into MMRhigh TAMs, causing a significant decline in tumor growth. This is accompanied by a repolarization of TAMs towards a pro-inflammatory phenotype and an increase in anti-tumor T cell responses. Therefore, the therapeutic benefit of such nanobody-drug conjugates may pave the road towards effective macrophage re-educating cancer immunotherapies.
- Autoren
- Evangelia Bolli
- Maximilian Scherger
- Sana M Arnouk
- Ana Rita Pombo Antunes
- David Straßburger
- Moritz Urschbach
- Judith Stickdorn
- Karen De Vlaminck
- Kiavash Movahedi
- Hans Joachim Räder
- Sophie Hernot
- Pol Besenius
- Jo A Van Ginderachter
- Lutz Nuhn
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/34026453
- DOI
- 10.1002/advs.202004574
- eISSN
- 2198-3844
- Externe Identifier
- PubMed Central ID: PMC8132149
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Adv Sci (Weinh)
- Schlüsselwörter
- M2 macrophages
- TLR 7/8 agonist
- cancer immunotherapy
- drug delivery
- nanobodies
- repolarization
- tumor associated macrophages
- Animals
- Disease Models, Animal
- Imidazoles
- Lung Neoplasms
- Mannose Receptor
- Membrane Glycoproteins
- Mice, Inbred C57BL
- Mice, Knockout
- Quinolines
- Single-Domain Antibodies
- Toll-Like Receptor 6
- Toll-Like Receptor 7
- Tumor Microenvironment
- Tumor-Associated Macrophages
- Mice
- Sprache
- eng
- Country
- Germany
- Paginierung
- 2004574
- PII
- ADVS2507
- Datum der Veröffentlichung
- 2021
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Targeted Repolarization of Tumor-Associated Macrophages via Imidazoquinoline-Linked Nanobodies.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 8
Datenquelle: PubMed
- Beziehungen:
-