Serum Ferritin Levels in Severe Obstructive Sleep Apnea
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Christopher Seifen
- Johannes Pordzik
- Tilman Huppertz
- Berit Hackenberg
- Cornelia Schupp
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000955741400001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/diagnostics13061154
- eISSN
- 2075-4418
- Externe Identifier
- Clarivate Analytics Document Solution ID: A5TK7
- PubMed Identifier: 36980461
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- DIAGNOSTICS
- Schlüsselwörter
- obstructive sleep apnea
- OSA
- serum ferritin
- ferritin
- iron metabolism
- inflammation
- CRP
- obesity
- BMI
- Artikelnummer
- ARTN 1154
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Titel
- Serum Ferritin Levels in Severe Obstructive Sleep Apnea
- Sub types
- Article
- Ausgabe der Zeitschrift
- 13
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>Obstructive sleep apnea (OSA) has been associated with various acute and chronic inflammatory diseases, as has serum ferritin, an intracellular iron storage protein. Little is known about the relationship between severity of OSA and serum ferritin levels in otherwise healthy subjects. In this study, all polysomnographic recordings, serum levels of ferritin, C-reactive protein (CRP), and hemoglobin, as well as patient files from 90 consecutive, otherwise healthy individuals with suspected OSA who presented to a tertiary sleep medical center were retrospectively analyzed. For comparison, three groups were formed based on apnea–hypopnea index (AHI; none or mild OSA: <15/h vs. moderate OSA: 15–30/h vs. severe OSA: >30/h). Serum ferritin levels were significantly positively correlated with AHI (r = 0.3240, p = 0.0020). A clear trend of higher serum ferritin levels was found when patients with severe OSA were compared to those without or with mild OSA. Serum CRP and serum hemoglobin levels did not differ significantly among OSA severity groups. Age and body–mass index (BMI) tended to be higher with increasing OSA severity. The BMI was significant higher in patients with severe OSA compared to those without or with mild (p < 0.001). Therefore, serum ferritin levels may provide a biochemical surrogate marker for OSA severity.</jats:p>
- Autoren
- Christopher Seifen
- Johannes Pordzik
- Tilman Huppertz
- Berit Hackenberg
- Cornelia Schupp
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- DOI
- 10.3390/diagnostics13061154
- eISSN
- 2075-4418
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- Diagnostics
- Sprache
- en
- Online publication date
- 2023
- Paginierung
- 1154 - 1154
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/diagnostics13061154
- Datum der Datenerfassung
- 2023
- Titel
- Serum Ferritin Levels in Severe Obstructive Sleep Apnea
- Ausgabe der Zeitschrift
- 13
Datenquelle: Crossref
- Abstract
- Obstructive sleep apnea (OSA) has been associated with various acute and chronic inflammatory diseases, as has serum ferritin, an intracellular iron storage protein. Little is known about the relationship between severity of OSA and serum ferritin levels in otherwise healthy subjects. In this study, all polysomnographic recordings, serum levels of ferritin, C-reactive protein (CRP), and hemoglobin, as well as patient files from 90 consecutive, otherwise healthy individuals with suspected OSA who presented to a tertiary sleep medical center were retrospectively analyzed. For comparison, three groups were formed based on apnea-hypopnea index (AHI; none or mild OSA: <15/h vs. moderate OSA: 15-30/h vs. severe OSA: >30/h). Serum ferritin levels were significantly positively correlated with AHI (r = 0.3240, <i>p</i> = 0.0020). A clear trend of higher serum ferritin levels was found when patients with severe OSA were compared to those without or with mild OSA. Serum CRP and serum hemoglobin levels did not differ significantly among OSA severity groups. Age and body-mass index (BMI) tended to be higher with increasing OSA severity. The BMI was significant higher in patients with severe OSA compared to those without or with mild (<i>p</i> < 0.001). Therefore, serum ferritin levels may provide a biochemical surrogate marker for OSA severity.
- Addresses
- Sleep Medicine Center, Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany.
- Autoren
- Christopher Seifen
- Johannes Pordzik
- Tilman Huppertz
- Berit Hackenberg
- Cornelia Schupp
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- DOI
- 10.3390/diagnostics13061154
- eISSN
- 2075-4418
- Externe Identifier
- PubMed Identifier: 36980461
- PubMed Central ID: PMC10047524
- Open access
- true
- ISSN
- 2075-4418
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- Diagnostics (Basel, Switzerland)
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2023
- Open access status
- Open Access
- Paginierung
- 1154
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2023
- Titel
- Serum Ferritin Levels in Severe Obstructive Sleep Apnea.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 13
Files
https://www.mdpi.com/2075-4418/13/6/1154/pdf?version=1679049117 https://europepmc.org/articles/PMC10047524?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Obstructive sleep apnea (OSA) has been associated with various acute and chronic inflammatory diseases, as has serum ferritin, an intracellular iron storage protein. Little is known about the relationship between severity of OSA and serum ferritin levels in otherwise healthy subjects. In this study, all polysomnographic recordings, serum levels of ferritin, C-reactive protein (CRP), and hemoglobin, as well as patient files from 90 consecutive, otherwise healthy individuals with suspected OSA who presented to a tertiary sleep medical center were retrospectively analyzed. For comparison, three groups were formed based on apnea-hypopnea index (AHI; none or mild OSA: <15/h vs. moderate OSA: 15-30/h vs. severe OSA: >30/h). Serum ferritin levels were significantly positively correlated with AHI (r = 0.3240, p = 0.0020). A clear trend of higher serum ferritin levels was found when patients with severe OSA were compared to those without or with mild OSA. Serum CRP and serum hemoglobin levels did not differ significantly among OSA severity groups. Age and body-mass index (BMI) tended to be higher with increasing OSA severity. The BMI was significant higher in patients with severe OSA compared to those without or with mild (p < 0.001). Therefore, serum ferritin levels may provide a biochemical surrogate marker for OSA severity.
- Date of acceptance
- 2023
- Autoren
- Christopher Seifen
- Johannes Pordzik
- Tilman Huppertz
- Berit Hackenberg
- Cornelia Schupp
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36980461
- DOI
- 10.3390/diagnostics13061154
- Externe Identifier
- PubMed Central ID: PMC10047524
- ISSN
- 2075-4418
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- Diagnostics (Basel)
- Schlüsselwörter
- BMI
- CRP
- OSA
- ferritin
- inflammation
- iron metabolism
- obesity
- obstructive sleep apnea
- serum ferritin
- Sprache
- eng
- Country
- Switzerland
- PII
- diagnostics13061154
- Datum der Veröffentlichung
- 2023
- Status
- Published online
- Titel
- Serum Ferritin Levels in Severe Obstructive Sleep Apnea.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 13
Datenquelle: PubMed
- Beziehungen:
- Eigentum von