Central Apneic Event Prevalence in REM and NREM Sleep in OSA Patients: A Retrospective, Exploratory Study
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Katharina Ludwig
- Sebastian Malatantis-Ewert
- Tilman Huppertz
- Katharina Bahr-Hamm
- Christopher Seifen
- Johannes Pordzik
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000938388200001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/biology12020298
- eISSN
- 2079-7737
- Externe Identifier
- Clarivate Analytics Document Solution ID: 9G8HX
- PubMed Identifier: 36829574
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- BIOLOGY-BASEL
- Schlüsselwörter
- central sleep apnea
- sleep stages
- polysomnography
- chemosensitivity
- obstructive sleep apnea
- REM sleep
- Artikelnummer
- ARTN 298
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Titel
- Central Apneic Event Prevalence in REM and NREM Sleep in OSA Patients: A Retrospective, Exploratory Study
- Sub types
- Article
- Ausgabe der Zeitschrift
- 12
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>Patients with sleep-disordered breathing show a combination of different respiratory events (central, obstructive, mixed), with one type being predominant. We observed a reduced prevalence of central apneic events (CAEs) during REM sleep compared to NREM sleep in patients with predominant obstructive sleep apnea (OSA). The aim of this retrospective, exploratory study was to describe this finding and to suggest pathophysiological explanations. The polysomnography (PSG) data of 141 OSA patients were assessed for the prevalence of CAEs during REM and NREM sleep. On the basis of the apnea–hypopnea index (AHI), patients were divided into three OSA severity groups (mild: AHI < 15/h; moderate: AHI = 15–30/h; severe: AHI > 30/h). We compared the frequency of CAEs adjusted for the relative length of REM and NREM sleep time, and a significantly increased frequency of CAEs in NREM was found only in severely affected OSA patients. Given that the emergence of CAEs is strongly associated with the chemosensitivity of the brainstem nuclei regulating breathing mechanics in humans, a sleep-stage-dependent chemosensitivity is proposed. REM-sleep-associated neuronal circuits in humans may act protectively against the emergence of CAEs, possibly by reducing chemosensitivity. On the contrary, a significant increase in the chemosensitivity of the brainstem nuclei during NREM sleep is suggested.</jats:p>
- Autoren
- Katharina Ludwig
- Sebastian Malatantis-Ewert
- Tilman Huppertz
- Katharina Bahr-Hamm
- Christopher Seifen
- Johannes Pordzik
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- DOI
- 10.3390/biology12020298
- eISSN
- 2079-7737
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Biology
- Sprache
- en
- Online publication date
- 2023
- Paginierung
- 298 - 298
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/biology12020298
- Datum der Datenerfassung
- 2023
- Titel
- Central Apneic Event Prevalence in REM and NREM Sleep in OSA Patients: A Retrospective, Exploratory Study
- Ausgabe der Zeitschrift
- 12
Datenquelle: Crossref
- Abstract
- Patients with sleep-disordered breathing show a combination of different respiratory events (central, obstructive, mixed), with one type being predominant. We observed a reduced prevalence of central apneic events (CAEs) during REM sleep compared to NREM sleep in patients with predominant obstructive sleep apnea (OSA). The aim of this retrospective, exploratory study was to describe this finding and to suggest pathophysiological explanations. The polysomnography (PSG) data of 141 OSA patients were assessed for the prevalence of CAEs during REM and NREM sleep. On the basis of the apnea-hypopnea index (AHI), patients were divided into three OSA severity groups (mild: AHI < 15/h; moderate: AHI = 15-30/h; severe: AHI > 30/h). We compared the frequency of CAEs adjusted for the relative length of REM and NREM sleep time, and a significantly increased frequency of CAEs in NREM was found only in severely affected OSA patients. Given that the emergence of CAEs is strongly associated with the chemosensitivity of the brainstem nuclei regulating breathing mechanics in humans, a sleep-stage-dependent chemosensitivity is proposed. REM-sleep-associated neuronal circuits in humans may act protectively against the emergence of CAEs, possibly by reducing chemosensitivity. On the contrary, a significant increase in the chemosensitivity of the brainstem nuclei during NREM sleep is suggested.
- Addresses
- Sleep Medicine Center, Department of Otorhinolaryngology, University Medical Center, Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
- Autoren
- Katharina Ludwig
- Sebastian Malatantis-Ewert
- Tilman Huppertz
- Katharina Bahr-Hamm
- Christopher Seifen
- Johannes Pordzik
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- DOI
- 10.3390/biology12020298
- eISSN
- 2079-7737
- Externe Identifier
- PubMed Identifier: 36829574
- PubMed Central ID: PMC9953334
- Open access
- true
- ISSN
- 2079-7737
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Biology
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2023
- Open access status
- Open Access
- Paginierung
- 298
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2023
- Titel
- Central Apneic Event Prevalence in REM and NREM Sleep in OSA Patients: A Retrospective, Exploratory Study.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 12
Files
https://www.mdpi.com/2079-7737/12/2/298/pdf?version=1676441651 https://europepmc.org/articles/PMC9953334?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Patients with sleep-disordered breathing show a combination of different respiratory events (central, obstructive, mixed), with one type being predominant. We observed a reduced prevalence of central apneic events (CAEs) during REM sleep compared to NREM sleep in patients with predominant obstructive sleep apnea (OSA). The aim of this retrospective, exploratory study was to describe this finding and to suggest pathophysiological explanations. The polysomnography (PSG) data of 141 OSA patients were assessed for the prevalence of CAEs during REM and NREM sleep. On the basis of the apnea-hypopnea index (AHI), patients were divided into three OSA severity groups (mild: AHI < 15/h; moderate: AHI = 15-30/h; severe: AHI > 30/h). We compared the frequency of CAEs adjusted for the relative length of REM and NREM sleep time, and a significantly increased frequency of CAEs in NREM was found only in severely affected OSA patients. Given that the emergence of CAEs is strongly associated with the chemosensitivity of the brainstem nuclei regulating breathing mechanics in humans, a sleep-stage-dependent chemosensitivity is proposed. REM-sleep-associated neuronal circuits in humans may act protectively against the emergence of CAEs, possibly by reducing chemosensitivity. On the contrary, a significant increase in the chemosensitivity of the brainstem nuclei during NREM sleep is suggested.
- Date of acceptance
- 2023
- Autoren
- Katharina Ludwig
- Sebastian Malatantis-Ewert
- Tilman Huppertz
- Katharina Bahr-Hamm
- Christopher Seifen
- Johannes Pordzik
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36829574
- DOI
- 10.3390/biology12020298
- Externe Identifier
- PubMed Central ID: PMC9953334
- ISSN
- 2079-7737
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Biology (Basel)
- Schlüsselwörter
- REM sleep
- central sleep apnea
- chemosensitivity
- obstructive sleep apnea
- polysomnography
- sleep stages
- Sprache
- eng
- Country
- Switzerland
- PII
- biology12020298
- Datum der Veröffentlichung
- 2023
- Status
- Published online
- Titel
- Central Apneic Event Prevalence in REM and NREM Sleep in OSA Patients: A Retrospective, Exploratory Study.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 12
Datenquelle: PubMed
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- Eigentum von