Supramolecular Stability of Benzene-1,3,5-tricarboxamide Supramolecular Polymers in Biological Media: Beyond the Stability-Responsiveness Trade-off
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Silvia Pujals
- Lorenzo Albertazzi
- Edgar Fuentes
- Yeray Gabaldon
- Mario Collado
- Shikha Dhiman
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000885515500001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1021/jacs.2c08528
- eISSN
- 1520-5126
- Externe Identifier
- Clarivate Analytics Document Solution ID: 6H5YU
- PubMed Identifier: 36368016
- ISSN
- 0002-7863
- Zeitschrift
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Supramolecular Stability of Benzene-1,3,5-tricarboxamide Supramolecular Polymers in Biological Media: Beyond the Stability-Responsiveness Trade-off
- Sub types
- Article
- Early Access
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Edgar Fuentes
- Yeray Gabaldón
- Mario Collado
- Shikha Dhiman
- José Augusto Berrocal
- Silvia Pujals
- Lorenzo Albertazzi
- DOI
- 10.1021/jacs.2c08528
- eISSN
- 1520-5126
- ISSN
- 0002-7863
- Ausgabe der Veröffentlichung
- 46
- Zeitschrift
- Journal of the American Chemical Society
- Sprache
- en
- Online publication date
- 2022
- Paginierung
- 21196 - 21205
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Herausgeber
- American Chemical Society (ACS)
- Herausgeber URL
- http://dx.doi.org/10.1021/jacs.2c08528
- Datum der Datenerfassung
- 2023
- Titel
- Supramolecular Stability of Benzene-1,3,5-tricarboxamide Supramolecular Polymers in Biological Media: Beyond the Stability–Responsiveness Trade-off
- Ausgabe der Zeitschrift
- 144
Datenquelle: Crossref
- Abstract
- Supramolecular assemblies have been gaining attention in recent years in the field of drug delivery because of their unique formulation possibilities and adaptive behavior. Their non-covalent nature allows for their self-assembly formulation and responsiveness to stimuli, an appealing feature to trigger a therapeutic action with spatiotemporal control. However, facing in vivo conditions is very challenging for non-covalent structures. Dilution and proteins in blood can have a direct impact on self-assembly, destabilizing the supramolecules and leading to a premature and uncontrolled cargo release. To rationalize this behavior, we designed three monomers exhibiting distinct hydrophobic cores that self-assemble into photo-responsive fibers. We estimated their stability-responsiveness trade-off in vitro, finding two well-separated regimes. These are low-robustness regime, in which the system equilibrates quickly and responds readily to stimuli, and high-robustness regime, in which the system equilibrates slowly and is quite insensitive to stimuli. We probed the performance of both regimes in a complex environment using Förster resonance energy transfer (FRET). Interestingly, the stability-responsiveness trade-off defines perfectly the extent of disassembly caused by dilution but not the one caused by protein interaction. This identifies a disconnection between intrinsic supramolecular robustness and supramolecular stability in the biological environment, strongly influenced by the disassembly pathway upon protein interaction. These findings shed light on the key features to address for supramolecular stability in the biological environment.
- Addresses
- Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.
- Autoren
- Edgar Fuentes
- Yeray Gabaldón
- Mario Collado
- Shikha Dhiman
- José Augusto Berrocal
- Silvia Pujals
- Lorenzo Albertazzi
- DOI
- 10.1021/jacs.2c08528
- eISSN
- 1520-5126
- Externe Identifier
- PubMed Identifier: 36368016
- PubMed Central ID: PMC9706554
- Funding acknowledgements
- Dutch Research Council (NWO): 723.014.006
- Generalitat de Catalunya:
- European Research Council: 757397
- ?la Caixa? Foundation: 100010434
- Ministerio de Econom?a y Competitividad: BES-2017-080188
- Open access
- true
- ISSN
- 0002-7863
- Ausgabe der Veröffentlichung
- 46
- Zeitschrift
- Journal of the American Chemical Society
- Schlüsselwörter
- Benzamides
- Benzene
- Polymers
- Hydrophobic and Hydrophilic Interactions
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2022
- Open access status
- Open Access
- Paginierung
- 21196 - 21205
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- Supramolecular Stability of Benzene-1,3,5-tricarboxamide Supramolecular Polymers in Biological Media: Beyond the Stability-Responsiveness Trade-off.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 144
Files
https://europepmc.org/articles/PMC9706554?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Supramolecular assemblies have been gaining attention in recent years in the field of drug delivery because of their unique formulation possibilities and adaptive behavior. Their non-covalent nature allows for their self-assembly formulation and responsiveness to stimuli, an appealing feature to trigger a therapeutic action with spatiotemporal control. However, facing in vivo conditions is very challenging for non-covalent structures. Dilution and proteins in blood can have a direct impact on self-assembly, destabilizing the supramolecules and leading to a premature and uncontrolled cargo release. To rationalize this behavior, we designed three monomers exhibiting distinct hydrophobic cores that self-assemble into photo-responsive fibers. We estimated their stability-responsiveness trade-off in vitro, finding two well-separated regimes. These are low-robustness regime, in which the system equilibrates quickly and responds readily to stimuli, and high-robustness regime, in which the system equilibrates slowly and is quite insensitive to stimuli. We probed the performance of both regimes in a complex environment using Förster resonance energy transfer (FRET). Interestingly, the stability-responsiveness trade-off defines perfectly the extent of disassembly caused by dilution but not the one caused by protein interaction. This identifies a disconnection between intrinsic supramolecular robustness and supramolecular stability in the biological environment, strongly influenced by the disassembly pathway upon protein interaction. These findings shed light on the key features to address for supramolecular stability in the biological environment.
- Autoren
- Edgar Fuentes
- Yeray Gabaldón
- Mario Collado
- Shikha Dhiman
- José Augusto Berrocal
- Silvia Pujals
- Lorenzo Albertazzi
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36368016
- DOI
- 10.1021/jacs.2c08528
- eISSN
- 1520-5126
- Externe Identifier
- PubMed Central ID: PMC9706554
- Ausgabe der Veröffentlichung
- 46
- Zeitschrift
- J Am Chem Soc
- Schlüsselwörter
- Benzene
- Benzamides
- Hydrophobic and Hydrophilic Interactions
- Polymers
- Sprache
- eng
- Country
- United States
- Paginierung
- 21196 - 21205
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Supramolecular Stability of Benzene-1,3,5-tricarboxamide Supramolecular Polymers in Biological Media: Beyond the Stability-Responsiveness Trade-off.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 144
Datenquelle: PubMed
- Beziehungen:
-