Visual acuity, amblyopia, and vision-related quality of life in preterm adults with and without ROP: results from the Gutenberg prematurity eye study

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Objectives</jats:title> <jats:p>This study investigated the effects of prematurity and ROP on visual acuity and VRQoL in adults (18–52 years).</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>The Gutenberg Prematurity Eye Study is a retrospective cohort study with a prospective ophthalmologic examination. Preterm and full-term participants at an age from 18 to 52 years were included. Distant corrected visual acuity (DCVA) and VRQoL were assessed in participants (892 eyes of 450 individuals aged 28.6 ± 8.6 years, 251 females) grouped into full-term controls (gestational age [GA] at birth ≥37 weeks), preterm participants without ROP and GA 33–36 weeks (group 2), GA 29–32 weeks (group 3), GA ≤ 28 weeks (group 4), non-treated ROP (group 5) and treated ROP (group 6). Main outcome measures were distant corrected visual acuity (DCVA), VRQoL and prevalence of amblyopia.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>The DCVA of the better eye correlated (<jats:italic>p</jats:italic> &lt; 0.001) with GA, birth weight, ROP, ROP treatment, and perinatal adverse events and was poorer in both ROP groups. Visual acuity of &lt;20/200 in the better eye was observed in two participants (4.2%) in the ROP group and one person (6.7%) in the treated ROP group. The prevalence of amblyopia increased in the ROP groups. Compared to full-term controls, visual functioning VRQoL scores were lower in preterm individuals independent of ROP while socioemotional VRQoL scores were only lower in the treated ROP group.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Participants with postnatal ROP and its treatment showed decreased visual acuity and VRQol in adulthood, with amblyopia occurring more frequently in more preterm participants with ROP.</jats:p> </jats:sec>
Autoren
  • Achim Fieß
  • Katrin Greven
  • Eva Mildenberger
  • Michael S Urschitz
  • Heike M Elflein
  • Fred Zepp
  • Bernhard Stoffelns
  • Norbert Pfeiffer
  • Alexander K Schuster
DOI
10.1038/s41433-022-02207-y
eISSN
1476-5454
ISSN
0950-222X
Ausgabe der Veröffentlichung
9
Zeitschrift
Eye
Sprache
en
Online publication date
2022
Paginierung
1794 - 1801
Datum der Veröffentlichung
2023
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1038/s41433-022-02207-y
Datum der Datenerfassung
2023
Titel
Visual acuity, amblyopia, and vision-related quality of life in preterm adults with and without ROP: results from the Gutenberg prematurity eye study
Ausgabe der Zeitschrift
37

Datenquelle: Crossref

Andere Metadatenquellen:
Author's licence
CC-BY
Autoren
  • Achim Fieß
  • Katrin Greven
  • Eva Mildenberger
  • Michael S Urschitz
  • Heike M Elflein
  • Fred Zepp
  • Bernhard Stoffelns
  • Norbert Pfeiffer
  • Alexander K Schuster
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-H
Resource version
Published version
DOI
10.1038/s41433-022-02207-y
Funding acknowledgements
  • Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577
File(s) embargoed
false
Open access
true
ISSN
1476-5454
Zeitschrift
Eye
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Datum der Veröffentlichung
2022
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/8390
Herausgeber
Nature Publishing Group
Datum der Datenerfassung
2023
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Zugang
Public
Titel
Visual acuity, amblyopia, and vision-related quality of life in preterm adults with and without ROP : results from the Gutenberg prematurity eye study
Ausgabe der Zeitschrift
Version of Record (VoR)

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visual_acuity_amblyopia_and_v-20221121132944431.pdf

Datenquelle: OPENSCIENCE.UB

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