Confinement-Induced Fractionation and Liquid-Liquid Phase Separation of Polymer Mixtures
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Arash Nikoubashman
- Miho Yanagisawa
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000930060000001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/polym15030511
- eISSN
- 2073-4360
- Externe Identifier
- Clarivate Analytics Document Solution ID: 8U6LA
- PubMed Identifier: 36771812
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- POLYMERS
- Schlüsselwörter
- phase separation
- polymer mixture
- droplet
- protocell
- confinement
- molecular simulation
- PEG
- Dextran
- Artikelnummer
- ARTN 511
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Titel
- Confinement-Induced Fractionation and Liquid-Liquid Phase Separation of Polymer Mixtures
- Sub types
- Article
- Ausgabe der Zeitschrift
- 15
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>The formation of (bio)molecular condensates via liquid–liquid phase separation in cells has received increasing attention, as these aggregates play important functional and regulatory roles within biological systems. However, the majority of studies focused on the behavior of pure systems in bulk solutions, thus neglecting confinement effects and the interplay between the numerous molecules present in cells. To better understand the physical mechanisms driving condensation in cellular environments, we perform molecular simulations of binary polymer mixtures in spherical droplets, considering both monodisperse and polydisperse molecular weight distributions for the longer polymer species. We find that confinement induces a spatial separation of the polymers by length, with the longer ones moving to the droplet center. This partitioning causes a distinct increase in the local polymer concentration near the droplet center, which is more pronounced in polydisperse systems. Consequently, the confined systems exhibit liquid–liquid phase separation at average polymer concentrations where bulk systems are still in the one-phase regime.</jats:p>
- Autoren
- Arash Nikoubashman
- Miho Yanagisawa
- DOI
- 10.3390/polym15030511
- eISSN
- 2073-4360
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Polymers
- Sprache
- en
- Online publication date
- 2023
- Paginierung
- 511 - 511
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/polym15030511
- Datum der Datenerfassung
- 2023
- Titel
- Confinement-Induced Fractionation and Liquid–Liquid Phase Separation of Polymer Mixtures
- Ausgabe der Zeitschrift
- 15
Datenquelle: Crossref
- Abstract
- The formation of (bio)molecular condensates via liquid-liquid phase separation in cells has received increasing attention, as these aggregates play important functional and regulatory roles within biological systems. However, the majority of studies focused on the behavior of pure systems in bulk solutions, thus neglecting confinement effects and the interplay between the numerous molecules present in cells. To better understand the physical mechanisms driving condensation in cellular environments, we perform molecular simulations of binary polymer mixtures in spherical droplets, considering both monodisperse and polydisperse molecular weight distributions for the longer polymer species. We find that confinement induces a spatial separation of the polymers by length, with the longer ones moving to the droplet center. This partitioning causes a distinct increase in the local polymer concentration near the droplet center, which is more pronounced in polydisperse systems. Consequently, the confined systems exhibit liquid-liquid phase separation at average polymer concentrations where bulk systems are still in the one-phase regime.
- Addresses
- Institute of Physics, Johannes Gutenberg University Mainz, Staudingerweg 7, 55128 Mainz, Germany.
- Autoren
- Arash Nikoubashman
- Miho Yanagisawa
- DOI
- 10.3390/polym15030511
- eISSN
- 2073-4360
- Externe Identifier
- PubMed Identifier: 36771812
- PubMed Central ID: PMC9921168
- Funding acknowledgements
- Japan Society for the Promotion of Science: 22H01188
- Deutsche Forschungsgemeinschaft: 470113688
- Japan Science and Technology Agency: JPMJFR213Y
- Open access
- true
- ISSN
- 2073-4360
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Polymers
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2023
- Open access status
- Open Access
- Paginierung
- 511
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2023
- Titel
- Confinement-Induced Fractionation and Liquid-Liquid Phase Separation of Polymer Mixtures.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 15
Files
https://www.mdpi.com/2073-4360/15/3/511/pdf?version=1675152161 https://europepmc.org/articles/PMC9921168?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- The formation of (bio)molecular condensates via liquid-liquid phase separation in cells has received increasing attention, as these aggregates play important functional and regulatory roles within biological systems. However, the majority of studies focused on the behavior of pure systems in bulk solutions, thus neglecting confinement effects and the interplay between the numerous molecules present in cells. To better understand the physical mechanisms driving condensation in cellular environments, we perform molecular simulations of binary polymer mixtures in spherical droplets, considering both monodisperse and polydisperse molecular weight distributions for the longer polymer species. We find that confinement induces a spatial separation of the polymers by length, with the longer ones moving to the droplet center. This partitioning causes a distinct increase in the local polymer concentration near the droplet center, which is more pronounced in polydisperse systems. Consequently, the confined systems exhibit liquid-liquid phase separation at average polymer concentrations where bulk systems are still in the one-phase regime.
- Date of acceptance
- 2023
- Autoren
- Arash Nikoubashman
- Miho Yanagisawa
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36771812
- DOI
- 10.3390/polym15030511
- eISSN
- 2073-4360
- Externe Identifier
- PubMed Central ID: PMC9921168
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft: 470113688
- Japan Society for the Promotion of Science: 22H01188
- Japan Science and Technology Agency: JPMJFR213Y
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Polymers (Basel)
- Schlüsselwörter
- Dextran
- PEG
- confinement
- droplet
- molecular simulation
- phase separation
- polymer mixture
- protocell
- Sprache
- eng
- Country
- Switzerland
- PII
- polym15030511
- Datum der Veröffentlichung
- 2023
- Status
- Published online
- Titel
- Confinement-Induced Fractionation and Liquid-Liquid Phase Separation of Polymer Mixtures.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 15
Datenquelle: PubMed
- Beziehungen:
-