Gait Abnormalities in Parkinson's Disease Are Associated with Extracellular Free-Water Characteristics in the Substantia Nigra

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Manuel Bange
  • Gabriel Gonzalez-Escamilla
  • Nadine Sandra Claudia Lang
  • Hao Ding
  • Angela Radetz
  • Damian Marc Herz
  • Wolfgang Immanuel Schoellhorn
  • Muthuraman Muthuraman
  • Sergiu Groppa
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000826217800016&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3233/JPD-223225
eISSN
1877-718X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 2Y9OW
  • PubMed Identifier: 35570500
ISSN
1877-7171
Ausgabe der Veröffentlichung
5
Zeitschrift
JOURNAL OF PARKINSONS DISEASE
Schlüsselwörter
  • Parkinson's disease
  • gait
  • substantia nigra
  • free-water
  • diffusion-weighted imaging
Paginierung
1575 - 1590
Datum der Veröffentlichung
2022
Status
Published
Titel
Gait Abnormalities in Parkinson's Disease Are Associated with Extracellular Free-Water Characteristics in the Substantia Nigra
Sub types
  • Article
Ausgabe der Zeitschrift
12

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:p>Background: Gait impairments are common in Parkinson’s disease (PD). The pathological mechanisms are complex and not thoroughly elucidated, thus quantitative and objective parameters that closely relate to gait characteristics are critically needed to improve the diagnostic assessments and monitor disease progression. The substantia nigra is a relay structure within basal ganglia brainstem loops that is centrally involved in gait modulation. Objective: We tested the hypothesis that quantitative gait biomechanics are related to the microstructural integrity of the substantia nigra and PD-relevant gait abnormalities are independent from bradykinesia-linked speed reductions. Methods: Thirty-eight PD patients and 33 age-matched control participants walked on a treadmill at fixed speeds. Gait parameters were fed into a principal component analysis to delineate relevant features. We applied the neurite orientation dispersion and density imaging (NODDI) model on diffusion-weighted MR-images to calculate the free-water content as an advanced marker of microstructural integrity of the substantia nigra and tested its associations with gait parameters. Results: Patients showed increased duration of stance phase, load response, pre-swing, and double support time, as well as reduced duration of single support and swing time. Gait rhythmic alterations associated positively with the free-water content in the right substantia nigra in PD, indicating that patients with more severe neurodegeneration extend the duration of stance phase, load response, and pre-swing. Conclusion: The results provide evidence that gait alterations are not merely a byproduct of bradykinesia-related reduced walking speed. The data-supported association between free-water and the rhythmic component highlights the potential of substantia nigra microstructure imaging as a measure of gait-dysfunction and disease-progression.</jats:p>
Autoren
  • Manuel Bange
  • Gabriel Gonzalez-Escamilla
  • Nadine Sandra Claudia Lang
  • Hao Ding
  • Angela Radetz
  • Damian Marc Herz
  • Wolfgang Immanuel Schöllhorn
  • Muthuraman Muthuraman
  • Sergiu Groppa
DOI
10.3233/jpd-223225
eISSN
1877-718X
ISSN
1877-7171
Ausgabe der Veröffentlichung
5
Zeitschrift
Journal of Parkinson's Disease
Paginierung
1575 - 1590
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
IOS Press
Herausgeber URL
http://dx.doi.org/10.3233/jpd-223225
Datum der Datenerfassung
2022
Titel
Gait Abnormalities in Parkinson’s Disease Are Associated with Extracellular Free-Water Characteristics in the Substantia Nigra
Ausgabe der Zeitschrift
12

Datenquelle: Crossref

Abstract
<h4>Background</h4>Gait impairments are common in Parkinson's disease (PD). The pathological mechanisms are complex and not thoroughly elucidated, thus quantitative and objective parameters that closely relate to gait characteristics are critically needed to improve the diagnostic assessments and monitor disease progression. The substantia nigra is a relay structure within basal ganglia brainstem loops that is centrally involved in gait modulation.<h4>Objective</h4>We tested the hypothesis that quantitative gait biomechanics are related to the microstructural integrity of the substantia nigra and PD-relevant gait abnormalities are independent from bradykinesia-linked speed reductions.<h4>Methods</h4>Thirty-eight PD patients and 33 age-matched control participants walked on a treadmill at fixed speeds. Gait parameters were fed into a principal component analysis to delineate relevant features. We applied the neurite orientation dispersion and density imaging (NODDI) model on diffusion-weighted MR-images to calculate the free-water content as an advanced marker of microstructural integrity of the substantia nigra and tested its associations with gait parameters.<h4>Results</h4>Patients showed increased duration of stance phase, load response, pre-swing, and double support time, as well as reduced duration of single support and swing time. Gait rhythmic alterations associated positively with the free-water content in the right substantia nigra in PD, indicating that patients with more severe neurodegeneration extend the duration of stance phase, load response, and pre-swing.<h4>Conclusion</h4>The results provide evidence that gait alterations are not merely a byproduct of bradykinesia-related reduced walking speed. The data-supported association between free-water and the rhythmic component highlights the potential of substantia nigra microstructure imaging as a measure of gait-dysfunction and disease-progression.
Addresses
  • Section of Movement Disorders and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Autoren
  • Manuel Bange
  • Gabriel Gonzalez-Escamilla
  • Nadine Sandra Claudia Lang
  • Hao Ding
  • Angela Radetz
  • Damian Marc Herz
  • Wolfgang Immanuel Schöllhorn
  • Muthuraman Muthuraman
  • Sergiu Groppa
DOI
10.3233/jpd-223225
eISSN
1877-718X
Externe Identifier
  • PubMed Identifier: 35570500
Open access
false
ISSN
1877-7171
Ausgabe der Veröffentlichung
5
Zeitschrift
Journal of Parkinson's disease
Schlüsselwörter
  • Substantia Nigra
  • Humans
  • Parkinson Disease
  • Hypokinesia
  • Disease Progression
  • Water
  • Gait
Sprache
eng
Medium
Print
Paginierung
1575 - 1590
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2022
Titel
Gait Abnormalities in Parkinson's Disease Are Associated with Extracellular Free-Water Characteristics in the Substantia Nigra.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
12

Datenquelle: Europe PubMed Central

Abstract
BACKGROUND: Gait impairments are common in Parkinson's disease (PD). The pathological mechanisms are complex and not thoroughly elucidated, thus quantitative and objective parameters that closely relate to gait characteristics are critically needed to improve the diagnostic assessments and monitor disease progression. The substantia nigra is a relay structure within basal ganglia brainstem loops that is centrally involved in gait modulation. OBJECTIVE: We tested the hypothesis that quantitative gait biomechanics are related to the microstructural integrity of the substantia nigra and PD-relevant gait abnormalities are independent from bradykinesia-linked speed reductions. METHODS: Thirty-eight PD patients and 33 age-matched control participants walked on a treadmill at fixed speeds. Gait parameters were fed into a principal component analysis to delineate relevant features. We applied the neurite orientation dispersion and density imaging (NODDI) model on diffusion-weighted MR-images to calculate the free-water content as an advanced marker of microstructural integrity of the substantia nigra and tested its associations with gait parameters. RESULTS: Patients showed increased duration of stance phase, load response, pre-swing, and double support time, as well as reduced duration of single support and swing time. Gait rhythmic alterations associated positively with the free-water content in the right substantia nigra in PD, indicating that patients with more severe neurodegeneration extend the duration of stance phase, load response, and pre-swing. CONCLUSION: The results provide evidence that gait alterations are not merely a byproduct of bradykinesia-related reduced walking speed. The data-supported association between free-water and the rhythmic component highlights the potential of substantia nigra microstructure imaging as a measure of gait-dysfunction and disease-progression.
Autoren
  • Manuel Bange
  • Gabriel Gonzalez-Escamilla
  • Nadine Sandra Claudia Lang
  • Hao Ding
  • Angela Radetz
  • Damian Marc Herz
  • Wolfgang Immanuel Schöllhorn
  • Muthuraman Muthuraman
  • Sergiu Groppa
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/35570500
DOI
10.3233/JPD-223225
eISSN
1877-718X
Ausgabe der Veröffentlichung
5
Zeitschrift
J Parkinsons Dis
Schlüsselwörter
  • Parkinson’s disease
  • diffusion-weighted imaging
  • free-water
  • gait
  • substantia nigra
  • Disease Progression
  • Gait
  • Humans
  • Hypokinesia
  • Parkinson Disease
  • Substantia Nigra
  • Water
Sprache
eng
Country
Netherlands
Paginierung
1575 - 1590
PII
JPD223225
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Gait Abnormalities in Parkinson's Disease Are Associated with Extracellular Free-Water Characteristics in the Substantia Nigra.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
12

Datenquelle: PubMed

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