Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females

Abstract

Evidence suggests an increasing apnea–hypopnea index (AHI) with aging. However, the effect of aging on sleep-related metrics, especially AHI, has been less frequently investigated within different gender-specific subpopulations by taking prominent confounding factors, e.g., obstructive sleep apnea (OSA)-related comorbidities and body mass index (BMI) into account. Therefore, we retrospectively analyzed 186 first-time polysomnographic (PSG) recordings and medical files of all patients presented to a tertiary university sleep center during a 1-year period. Six groups were formed based on age (over vs. under 55 years) and gender: PSG-related parameters (AHI, apnea-index, and hypopnea-index) were significantly higher in the older mixed-gender cohort (p = 0.0001, p = 0.0011, and p = 0.0015, respectively), and the older female cohort (p = 0.0005, p = 0.0027, and p = 0.001, respectively). Within the older male cohort, the AHI and apnea-index were significantly higher (p = 0.0067, and p = 0.0135, respectively). Inter-group comparison of the BMI showed no significant difference in any subpopulation. Within the older male cohort there were significantly more patients with arterial hypertension, diabetes mellitus, cardiovascular diseases, and chronic mental health disorders (p < 0.0001, p = 0.001, p = 0.0181, and p = 0.0454, respectively). Contrarily, within the female subpopulation there were no significant differences for the aforementioned comorbidities. In conclusion, all investigated sleep PSG-parameters increased among the older subpopulations. We suggest that Osa severity may increase with age due to the increasing accumulation of comorbidities in males, but not in females.

Autoren

Christopher Seifen
Johannes Pordzik
Katharina Bahr
Lisa Große-Brüggemann
Katharina Ludwig
Berit Hackenberg
Christoph Matthias
Perikles Simon
Haralampos Gouveris

DOI

10.3390/jpm13010079

eISSN

2075-4426

Ausgabe der Veröffentlichung

1

Zeitschrift

Journal of Personalized Medicine

Sprache

en

Online publication date

2022

Paginierung

79 - 79

Status

Published online

Herausgeber

MDPI AG

Herausgeber URL

http://dx.doi.org/10.3390/jpm13010079

Datum der Datenerfassung

2022

Titel

Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females

Ausgabe der Zeitschrift

13

Datenquelle: Crossref

Abstract

Evidence suggests an increasing apnea−hypopnea index (AHI) with aging. However, the effect of aging on sleep-related metrics, especially AHI, has been less frequently investigated within different gender-specific subpopulations by taking prominent confounding factors, e.g., obstructive sleep apnea (OSA)-related comorbidities and body mass index (BMI) into account. Therefore, we retrospectively analyzed 186 first-time polysomnographic (PSG) recordings and medical files of all patients presented to a tertiary university sleep center during a 1-year period. Six groups were formed based on age (over vs. under 55 years) and gender: PSG-related parameters (AHI, apnea-index, and hypopnea-index) were significantly higher in the older mixed-gender cohort (p = 0.0001, p = 0.0011, and p = 0.0015, respectively), and the older female cohort (p = 0.0005, p = 0.0027, and p = 0.001, respectively). Within the older male cohort, the AHI and apnea-index were significantly higher (p = 0.0067, and p = 0.0135, respectively). Inter-group comparison of the BMI showed no significant difference in any subpopulation. Within the older male cohort there were significantly more patients with arterial hypertension, diabetes mellitus, cardiovascular diseases, and chronic mental health disorders (p < 0.0001, p = 0.001, p = 0.0181, and p = 0.0454, respectively). Contrarily, within the female subpopulation there were no significant differences for the aforementioned comorbidities. In conclusion, all investigated sleep PSG-parameters increased among the older subpopulations. We suggest that Osa severity may increase with age due to the increasing accumulation of comorbidities in males, but not in females.

Addresses

Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany.

Autoren

Christopher Seifen
Johannes Pordzik
Katharina Bahr
Lisa Große-Brüggemann
Katharina Ludwig
Berit Hackenberg
Christoph Matthias
Perikles Simon
Haralampos Gouveris

DOI

10.3390/jpm13010079

eISSN

2075-4426

Externe Identifier

PubMed Identifier: 36675741
PubMed Central ID: PMC9865863

Open access

true

ISSN

2075-4426

Ausgabe der Veröffentlichung

1

Zeitschrift

Journal of personalized medicine

Sprache

eng

Medium

Electronic

Online publication date

2022

Open access status

Open Access

Paginierung

79

Datum der Veröffentlichung

2022

Status

Published

Publisher licence

CC BY

Datum der Datenerfassung

2023

Titel

Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females.

Sub types

research-article
Journal Article

Ausgabe der Zeitschrift

13

Files

https://www.mdpi.com/2075-4426/13/1/79/pdf?version=1672305473 https://europepmc.org/articles/PMC9865863?pdf=render

Datenquelle: Europe PubMed Central

Abstract

Evidence suggests an increasing apnea−hypopnea index (AHI) with aging. However, the effect of aging on sleep-related metrics, especially AHI, has been less frequently investigated within different gender-specific subpopulations by taking prominent confounding factors, e.g., obstructive sleep apnea (OSA)-related comorbidities and body mass index (BMI) into account. Therefore, we retrospectively analyzed 186 first-time polysomnographic (PSG) recordings and medical files of all patients presented to a tertiary university sleep center during a 1-year period. Six groups were formed based on age (over vs. under 55 years) and gender: PSG-related parameters (AHI, apnea-index, and hypopnea-index) were significantly higher in the older mixed-gender cohort (p = 0.0001, p = 0.0011, and p = 0.0015, respectively), and the older female cohort (p = 0.0005, p = 0.0027, and p = 0.001, respectively). Within the older male cohort, the AHI and apnea-index were significantly higher (p = 0.0067, and p = 0.0135, respectively). Inter-group comparison of the BMI showed no significant difference in any subpopulation. Within the older male cohort there were significantly more patients with arterial hypertension, diabetes mellitus, cardiovascular diseases, and chronic mental health disorders (p < 0.0001, p = 0.001, p = 0.0181, and p = 0.0454, respectively). Contrarily, within the female subpopulation there were no significant differences for the aforementioned comorbidities. In conclusion, all investigated sleep PSG-parameters increased among the older subpopulations. We suggest that Osa severity may increase with age due to the increasing accumulation of comorbidities in males, but not in females.

Date of acceptance

2022

Autoren

Christopher Seifen
Johannes Pordzik
Katharina Bahr
Lisa Große-Brüggemann
Katharina Ludwig
Berit Hackenberg
Christoph Matthias
Perikles Simon
Haralampos Gouveris

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/36675741

DOI

10.3390/jpm13010079

Externe Identifier

PubMed Central ID: PMC9865863

ISSN

2075-4426

Ausgabe der Veröffentlichung

1

Zeitschrift

J Pers Med

Schlüsselwörter

age
apnea index
apnea–hypopnea index
hypopnea index
obstructive sleep apnea
obstructive sleep apnea and age

Sprache

eng

Country

Switzerland

PII

jpm13010079

Datum der Veröffentlichung

2022

Status

Published online

Titel

Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females.

Sub types

Journal Article

Ausgabe der Zeitschrift

13

Datenquelle: PubMed

Accumulating Comorbidities May Promote Increasing Severity of Obstructive Sleep Apnea with Aging in Males but Not in Females

Files

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