Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Publikationstyp:

Zeitschriftenaufsatz

Metadaten:

Autoren

Richard Karlsson Linner
Pietro Biroli
Edward Kong
Fleur W Meddens
Robbee Wedow
Mark Alan Fontana
Mael Lebreton
Stephen P Tino
Abdel Abdellaoui
Anke R Hammerschlag
Michel G Nivard
Aysu Okbay
Cornelius A Rietveld
Pascal N Timshel
Maciej Trzaskowski
Ronald de Vlaming
Christian L Zund
Yanchun Bao
Laura Buzdugan
Ann H Caplin
Chia-Yen Chen
Peter Eibich
Pierre Fontanillas
Juan R Gonzalez
Peter K Joshi
Ville Karhunen
Aaron Kleinman
Remy Z Levin
Christina M Lill
Gerardus A Meddens
Gerard Muntane
Sandra Sanchez-Roige
Frank J van Rooij
Erdogan Taskesen
Yang Wu
Futao Zhang
Michelle Agee
Babak Alipanahi
Robert K Bell
Katarzyna Bryc
Sarah L Elson
Nicholas A Furlotte
Karen E Huber
Nadia K Litterman
Jennifer C McCreight
Matthew H McIntyre
Joanna L Mountain
Carrie AM Northover
Steven J Pitts
J Fah Sathirapongsasuti
Olga V Sazonova
Janie F Shelton
Suyash Shringarpure
Chao Tian
Joyce Y Tung
Vladimir Vacic
Catherine H Wilson
Mawusse Agbessi
Habibul Ahsan
Isabel Alves
Anand Andiappan
Philip Awadalla
Alexis Battle
Frank Beutner
Marc Jan Bonder
Dorret I Boomsma
Mark Christiansen
Annique Claringbould
Patrick Deelen
Tonu Esko
Marie-Julie Fave
Lude Franke
Timothy Frayling
Sina A Gharib
Gregory Gibson
Bastiaan Heijmans
Gibran Hemani
Rick Jansen
Mika Kahonen
Anette Kalnapenkis
Silva Kasela
Johannes Kettunen
Yungil Kim
Holger Kirsten
Peter Kovacs
Knut Krohn
Jaanika Kronberg-Guzman
Viktorija Kukushkina
Zoltan Kutalik
Bernett Lee
Terho Lehtimaki
Markus Loeffler
Urko M Marigorta
Andres Metspalu
Lili Milani
Grant W Montgomery
Martina Mueller-Nurasyid
Matthias Nauck
Brenda Penninx
Markus Perola
Natalia Pervjakova
Brandon Pierce
Joseph Powell
Holger Prokisch
Bruce M Psaty
Olli Raitakari
Susan Ring
Samuli Ripatti
Olaf Rotzchke
Sina Rueger
Ashis Saha
Markus Scholz
Katharina Schramm
Ilkka Seppala
Michael Stumvoll
Patrick Sullivan
Peter-Bramt Hoen
Alexander Teumer
Joachim Thiery
Lin Tong
Anke Tonjes
Jenny van Dongen
Joyce van Meurs
Joost Verlouw
Peter M Visscher
Uwe Voelker
Urmo Vosa
Harm-Jan Westra
Hanieh Yaghootkar
Jian Yang
Biao Zeng
James J Lee
Tune H Pers
Patrick Turley
Guo-Bo Chen
Valur Emilsson
Sven Oskarsson
Joseph K Pickrell
Kevin Thom
Pascal Timshel
Tarunveer S Ahluwalia
Jonas Bacelis
Clemens Baumbach
Gyda Bjornsdottir
Johannes H Brandsma
Maria Pina Concas
Jaime Derringer
Nicholas A Furlotte
Tessel E Galesloot
Giorgia Girotto
Richa Gupta
Leanne M Hall
Sarah E Harris
Edith Hofer
Momoko Horikoshi
Jennifer E Huffman
Kadri Kaasik
Ioanna P Kalafati
Augustine Kong
Jari Lahti
Sven J van der Lee
Christiaan de Leeuw
Penelope A Lind
Karl-Oskar Lindgren
Tian Liu
Massimo Mangino
Jonathan Marten
Evelin Mihailov
Michael B Miller
Peter J van der Most
Christopher Oldmeadow
Antony Payton
Natalia Pervjakova
Wouter J Peyrot
Yong Qian
Olli Raitakari
Rico Rueedi
Erika Salvi
Boerge Schmidt
Katharina E Schraut
Jianxin Shi
Albert V Smith
Raymond A Poot
Beate St Pourcain
Alexander Teumer
Gudmar Thorleifsson
Niek Verweij
Dragana Vuckovic
Juergen Wellmann
Harm-Jan Westra
Jingyun Yang
Wei Zhao
Zhihong Zhu
Behrooz Z Alizadeh
Najaf Amin
Andrew Bakshi
Sebastian E Baumeister
Ginevra Biino
Klaus Bonnelykke
Patricia A Boyle
Harry Campbell
Francesco P Cappuccio
Gail Davies
Jan-Emmanuel De Neve
Panos Deloukas
Ilja Demuth
Jun Ding
Peter Eibich
Lewin Eisele
Niina Eklund
David M Evans
Jessica D Faul
Mary F Feitosa
Andreas J Forstner
Ilaria Gandin
Bjarni Gunnarsson
Bjarni V Halldorsson
Tamara B Harris
Andrew C Heath
Lynne J Hocking
Elizabeth G Holliday
Georg Homuth
Michael A Horan
Jouke-Jan Hottenga
Philip L de Jager
Astanand Jugessur
Marika A Kaakinen
Mika Kahonen
Stavroula Kanoni
Liisa Keltigangas-Jarvinen
Lambertus ALM Kiemeney
Ivana Kolcic
Seppo Koskinen
Aldi T Kraja
Martin Kroh
Zoltan Kutalik
Antti Latvala
Lenore J Launer
Mael P Lebreton
Douglas F Levinson
Paul Lichtenstein
Peter Lichtner
David CM Liewald
Anu Loukola
Pamela A Madden
Reedik Magi
Tomi Maki-Opas
Riccardo E Marioni
Pedro Marques-Vidal
George McMahon
Christa Meisinger
Thomas Meitinger
Yusplitri Milaneschi
Lili Milani
Grant W Montgomery
Ronny Myhre
Christopher P Nelson
Dale R Nyholt
William ER Ollier
Aarno Palotie
Lavinia Paternoster
Nancy L Pedersen
Katja E Petrovic
David J Porteous
Katri Raikkonen
Susan M Ring
Antonietta Robino
Olga Rostapshova
Igor Rudan
Aldo Rustichini
Veikko Salomaa
Alan R Sanders
Antti-Pekka Sarin
Helena Schmidt
Rodney J Scott
Blair H Smith
Jennifer A Smith
Jan A Staessen
Elisabeth Steinhagen-Thiessen
Konstantin Strauch
Antonio Terracciano
Martin D Tobin
Sheila Ulivi
Simona Vaccargiu
Lydia Quaye
Cristina Venturini
Anna AE Vinkhuyzen
Uwe Voelker
Henry Voelzke
Judith M Vonk
Diego Vozzi
Johannes Waage
Erin B Ware
Gonneke Willemsen
John R Attia
David A Bennett
Klaus Berger
Lars Bertram
Hans Bisgaard
Dorret I Boomsma
Ingrid B Borecki
Ute Bultmann
Christopher F Chabris
Francesco Cucca
Daniele Cusi
J Deary
George V Dedoussis
Cornelia M van Duijn
Johan G Eriksson
Barbara Franke
Lude Franke
Paolo Gasparini
Pablo V Gejman
Christian Gieger
Hans-Joergen Grabe
Jacob Gratten
Vilmundur Gudnason
Pim van der Harst
Caroline Hayward
David A Hinds
Wolfgang Hoffmann
Elina Hypponen
William G Iacono
Bo Jacobsson
Marjo-Riitta Jarvelin
Karl-Heinz Jockel
Jaakko Kaprio
Sharon LR Kardia
Terho Lehtimaki
Steven F Lehrer
Patrik KE Magnusson
Nicholas G Martin
Matt McGue
Andres Metspalu
Neil Pendleton
Brenda Penninx
Markus Perola
Nicola Pirastu
Mario Pirastu
Ozren Polasek
Danielle Posthuma
Christine Power
Michael A Province
Nilesh J Samani
David Schlessinger
Reinhold Schmidt
Thorkild IA Sorensen
Tim D Spector
Kari Stefansson
Unnur Thorsteinsdottir
A Roy Thurik
Nicholas J Timpson
Henning Tiemeier
Joyce Y Tung
Andre G Uitterlinden
Veronique Vitart
Peter Vollenweider
David R Weir
James F Wilson
Alan F Wright
Dalton C Conley
Robert F Krueger
George Davey Smith
David I Laibson
Sarah E Medland
Jian Yang
Magnus Johannesson
Peter M Visscher
Tonu Esko
Philipp D Koellinger
David Cesarini
Daniel J Benjamin
Adam Auton
Jason D Boardman
David W Clark
Andrew Conlin
Conor C Dolan
Urs Fischbacher
Patrick JF Groenen
Kathleen Mullan Harris
Gregor Hasler
Albert Hofman
Mohammad A Ikram
Sonia Jain
Robert Karlsson
Ronald C Kessler
Maarten Kooyman
James MacKillop
Minna Mannikko
Carlos Morcillo-Suarez
Matthew B McQueen
Klaus M Schmidt
Melissa C Smart
Matthias Sutter
A Roy Thurik
Andre G Uitterlinden
Jon White
Harriet de Wit
Jian Yang
Lars Bertram
Dorret I Boomsma
Tonu Esko
Ernst Fehr
David A Hinds
Magnus Johannesson
Meena Kumari
David Laibson
Patrik KE Magnusson
Michelle N Meyer
Arcadi Navarro
Abraham A Palmer
Tune H Pers
Danielle Posthuma
Daniel Schunk
Murray B Stein
Rauli Svento
Henning Tiemeier
Paul RHJ Timmers
Patrick Turley
Robert J Ursano
Gert G Wagner
James F Wilson
Jacob Gratten
James J Lee
David Cesarini
Daniel J Benjamin
Philipp D Koellinger
Jonathan P Beauchamp

Autoren-URL

https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000457314300011&DestLinkType=FullRecord&DestApp=WOS_CPL

DOI

10.1038/s41588-018-0309-3

eISSN

1546-1718

Externe Identifier

Clarivate Analytics Document Solution ID: HJ6PM
PubMed Identifier: 30643258

ISSN

1061-4036

Ausgabe der Veröffentlichung

Zeitschrift

NATURE GENETICS

Paginierung

245 - +

Datum der Veröffentlichung

2019

Status

Published

Titel

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Sub types

Article

Ausgabe der Zeitschrift

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:

Autoren

Richard Karlsson Linnér
Pietro Biroli
Edward Kong
S Fleur W Meddens
Robbee Wedow
Mark Alan Fontana
Maël Lebreton
Stephen P Tino
Abdel Abdellaoui
Anke R Hammerschlag
Michel G Nivard
Aysu Okbay
Cornelius A Rietveld
Pascal N Timshel
Maciej Trzaskowski
Ronald de Vlaming
Christian L Zünd
Yanchun Bao
Laura Buzdugan
Ann H Caplin
Chia-Yen Chen
Peter Eibich
Pierre Fontanillas
Juan R Gonzalez
Peter K Joshi
Ville Karhunen
Aaron Kleinman
Remy Z Levin
Christina M Lill
Gerardus A Meddens
Gerard Muntané
Sandra Sanchez-Roige
Frank J van Rooij
Erdogan Taskesen
Yang Wu
Futao Zhang
Adam Auton
Jason D Boardman
David W Clark
Andrew Conlin
Conor C Dolan
Urs Fischbacher
Patrick JF Groenen
Kathleen Mullan Harris
Gregor Hasler
Albert Hofman
Mohammad A Ikram
Sonia Jain
Robert Karlsson
Ronald C Kessler
Maarten Kooyman
James MacKillop
Minna Männikkö
Carlos Morcillo-Suarez
Matthew B McQueen
Klaus M Schmidt
Melissa C Smart
Matthias Sutter
A Roy Thurik
André G Uitterlinden
Jon White
Harriet de Wit
Jian Yang
Lars Bertram
Dorret I Boomsma
Tõnu Esko
Ernst Fehr
David A Hinds
Magnus Johannesson
Meena Kumari
David Laibson
Patrik KE Magnusson
Michelle N Meyer
Arcadi Navarro
Abraham A Palmer
Tune H Pers
Danielle Posthuma
Daniel Schunk
Murray B Stein
Rauli Svento
Henning Tiemeier
Paul RHJ Timmers
Patrick Turley
Robert J Ursano
Gert G Wagner
James F Wilson
Jacob Gratten
James J Lee
David Cesarini
Daniel J Benjamin
Philipp D Koellinger
Jonathan P Beauchamp

DOI

10.1038/s41588-018-0309-3

eISSN

1546-1718

ISSN

1061-4036

Ausgabe der Veröffentlichung

Zeitschrift

Nature Genetics

Sprache

Online publication date

2019

Paginierung

245 - 257

Datum der Veröffentlichung

2019

Status

Published

Herausgeber

Springer Science and Business Media LLC

Herausgeber URL

http://dx.doi.org/10.1038/s41588-018-0309-3

Datum der Datenerfassung

2023

Titel

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Ausgabe der Zeitschrift

Datenquelle: Crossref

Abstract

Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.

Addresses

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands. r.karlssonlinner@vu.nl.

Autoren

Richard Karlsson Linnér
Pietro Biroli
Edward Kong
S Fleur W Meddens
Robbee Wedow
Mark Alan Fontana
Maël Lebreton
Stephen P Tino
Abdel Abdellaoui
Anke R Hammerschlag
Michel G Nivard
Aysu Okbay
Cornelius A Rietveld
Pascal N Timshel
Maciej Trzaskowski
Ronald de Vlaming
Christian L Zünd
Yanchun Bao
Laura Buzdugan
Ann H Caplin
Chia-Yen Chen
Peter Eibich
Pierre Fontanillas
Juan R Gonzalez
Peter K Joshi
Ville Karhunen
Aaron Kleinman
Remy Z Levin
Christina M Lill
Gerardus A Meddens
Gerard Muntané
Sandra Sanchez-Roige
Frank J van Rooij
Erdogan Taskesen
Yang Wu
Futao Zhang
23and Me Research Team
eQTLgen Consortium
International Cannabis Consortium
Social Science Genetic Association Consortium
Adam Auton
Jason D Boardman
David W Clark
Andrew Conlin
Conor C Dolan
Urs Fischbacher
Patrick JF Groenen
Kathleen Mullan Harris
Gregor Hasler
Albert Hofman
Mohammad A Ikram
Sonia Jain
Robert Karlsson
Ronald C Kessler
Maarten Kooyman
James MacKillop
Minna Männikkö
Carlos Morcillo-Suarez
Matthew B McQueen
Klaus M Schmidt
Melissa C Smart
Matthias Sutter
A Roy Thurik
André G Uitterlinden
Jon White
Harriet de Wit
Jian Yang
Lars Bertram
Dorret I Boomsma
Tõnu Esko
Ernst Fehr
David A Hinds
Magnus Johannesson
Meena Kumari
David Laibson
Patrik KE Magnusson
Michelle N Meyer
Arcadi Navarro
Abraham A Palmer
Tune H Pers
Danielle Posthuma
Daniel Schunk
Murray B Stein
Rauli Svento
Henning Tiemeier
Paul RHJ Timmers
Patrick Turley
Robert J Ursano
Gert G Wagner
James F Wilson
Jacob Gratten
James J Lee
David Cesarini
Daniel J Benjamin
Philipp D Koellinger
Jonathan P Beauchamp

DOI

10.1038/s41588-018-0309-3

eISSN

1546-1718

Externe Identifier

PubMed Identifier: 30643258
PubMed Central ID: PMC6713272

Funding acknowledgements

Economic and Social Research Council: ES/N00812X/1
Medical Research Council: MC_UU_00007/10
National Institute for Health Research (NIHR): NIHR-RP-R3-12-013
Lundbeck Foundation: R190-2014-3904
Wellcome Trust: 213422/Z/18/Z
National Institute for Health Research (NIHR): NF-SI-0514-10027
NICHD NIH HHS: P01 HD031921
NNF Center for Basic Metabolic Research: Pers Group
Wellcome Trust: 208806/Z/17/Z
Medical Research Council: G0600237
Medical Research Council: MR/N01104X/1
Medical Research Council: MR/N01104X/2
Biotechnology and Biological Sciences Research Council: BB/F019394/1
Medical Research Council: G1001799
Medical Research Council: MR/K026992/1
Novo Nordisk Fonden: NNF16OC0021496
NIA NIH HHS: R01 AG017917
Economic and Social Research Council: ES/M008592/1
Medical Research Council: G0700704B
National Institute for Health Research (NIHR): NF-SI-0507-10228
NICHD NIH HHS: P2C HD066613
NIA NIH HHS: P30 AG012810
NIA NIH HHS: R01 AG015819
Economic and Social Research Council: ES/S008349/1
Medical Research Council: G0901461
Medical Research Council: MC_UU_12013/4
NIA NIH HHS: P01 AG005842
NIA NIH HHS: R01 AG033678
Medical Research Council: 1805084
Medical Research Council: 1811434
Biotechnology and Biological Sciences Research Council: BB/F022441/1
Medical Research Council: G0100594
NIA NIH HHS: T32 AG000186
Cancer Research UK: 10119
NIA NIH HHS: P30 AG010161
NIA NIH HHS: R01 AG042568
NICHD NIH HHS: R03 HD097630
NIA NIH HHS: R56 AG042568

Open access

false

ISSN

1061-4036

Ausgabe der Veröffentlichung

Zeitschrift

Nature genetics

Schlüsselwörter

23and Me Research Team
eQTLgen Consortium
International Cannabis Consortium
Social Science Genetic Association Consortium
Humans
Genetic Predisposition to Disease
Case-Control Studies
Behavior
Genetics, Behavioral
Genotype
Polymorphism, Single Nucleotide
Female
Male
Genome-Wide Association Study
Genetic Loci

Sprache

eng

Medium

Print-Electronic

Online publication date

2019

Paginierung

245 - 257

Datum der Veröffentlichung

2019

Status

Published

Datum der Datenerfassung

2019

Titel

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

Sub types

Meta-Analysis
Research Support, Non-U.S. Gov't
research-article
Journal Article

Ausgabe der Zeitschrift

Files

https://europepmc.org/articles/PMC6713272?pdf=render

Datenquelle: Europe PubMed Central

Abstract

Date of acceptance

2018

Autoren

Richard Karlsson Linnér
Pietro Biroli
Edward Kong
S Fleur W Meddens
Robbee Wedow
Mark Alan Fontana
Maël Lebreton
Stephen P Tino
Abdel Abdellaoui
Anke R Hammerschlag
Michel G Nivard
Aysu Okbay
Cornelius A Rietveld
Pascal N Timshel
Maciej Trzaskowski
Ronald de Vlaming
Christian L Zünd
Yanchun Bao
Laura Buzdugan
Ann H Caplin
Chia-Yen Chen
Peter Eibich
Pierre Fontanillas
Juan R Gonzalez
Peter K Joshi
Ville Karhunen
Aaron Kleinman
Remy Z Levin
Christina M Lill
Gerardus A Meddens
Gerard Muntané
Sandra Sanchez-Roige
Frank J van Rooij
Erdogan Taskesen
Yang Wu
Futao Zhang
23and Me Research Team
eQTLgen Consortium
International Cannabis Consortium
Social Science Genetic Association Consortium
Adam Auton
Jason D Boardman
David W Clark
Andrew Conlin
Conor C Dolan
Urs Fischbacher
Patrick JF Groenen
Kathleen Mullan Harris
Gregor Hasler
Albert Hofman
Mohammad A Ikram
Sonia Jain
Robert Karlsson
Ronald C Kessler
Maarten Kooyman
James MacKillop
Minna Männikkö
Carlos Morcillo-Suarez
Matthew B McQueen
Klaus M Schmidt
Melissa C Smart
Matthias Sutter
A Roy Thurik
André G Uitterlinden
Jon White
Harriet de Wit
Jian Yang
Lars Bertram
Dorret I Boomsma
Tõnu Esko
Ernst Fehr
David A Hinds
Magnus Johannesson
Meena Kumari
David Laibson
Patrik KE Magnusson
Michelle N Meyer
Arcadi Navarro
Abraham A Palmer
Tune H Pers
Danielle Posthuma
Daniel Schunk
Murray B Stein
Rauli Svento
Henning Tiemeier
Paul RHJ Timmers
Patrick Turley
Robert J Ursano
Gert G Wagner
James F Wilson
Jacob Gratten
James J Lee
David Cesarini
Daniel J Benjamin
Philipp D Koellinger
Jonathan P Beauchamp

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/30643258

DOI

10.1038/s41588-018-0309-3

eISSN

1546-1718

Externe Identifier

NIH Manuscript Submission ID: NIHMS1046638
PubMed Central ID: PMC6713272

Funding acknowledgements

NICHD NIH HHS: P01 HD031921
Biotechnology and Biological Sciences Research Council: BB/F022441/1
Medical Research Council: MR/N01104X/2
NIA NIH HHS: R56 AG042568
NIA NIH HHS: R01 AG033678
NICHD NIH HHS: R03 HD097630
NIA NIH HHS: P30 AG010161
Medical Research Council: G0600237
Medical Research Council: G0901461
Wellcome Trust: 208806/Z/17/Z
Medical Research Council: MR/K026992/1
Medical Research Council: G1001799
NIA NIH HHS: R01 AG017917
Medical Research Council: MC_UU_00007/10
Medical Research Council: G0100594
NICHD NIH HHS: P2C HD066613
Medical Research Council: MC_UU_12013/4
NIA NIH HHS: P01 AG005842
NIA NIH HHS: P30 AG012810
NIA NIH HHS: R01 AG042568
NIA NIH HHS: T32 AG000186
Biotechnology and Biological Sciences Research Council: BB/F019394/1
NIA NIH HHS: R01 AG015819
Cancer Research UK: 10119

Ausgabe der Veröffentlichung

Zeitschrift

Nat Genet

Schlüsselwörter

Behavior
Case-Control Studies
Female
Genetic Loci
Genetic Predisposition to Disease
Genetics, Behavioral
Genome-Wide Association Study
Genotype
Humans
Male
Polymorphism, Single Nucleotide

Sprache

eng

Country

United States

Paginierung

245 - 257

PII

10.1038/s41588-018-0309-3

Datum der Veröffentlichung

2019

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2019

Titel

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

Sub types

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

Datenquelle: PubMed

Abstract

Humans vary substantially in their willingness to take risks. In a combined sample of over one million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. We identified 611 approximately independent genetic loci associated with at least one of our phenotypes, including 124 with general risk tolerance. We report evidence of substantial shared genetic influences across general risk tolerance and risky behaviors: 72 of the 124 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is moderately to strongly genetically correlated with a range of risky behaviors. Bioinformatics analyses imply that genes near general-risk-tolerance-associated SNPs are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We find no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.

Addresses

University Amsterdam
University of Zurich
Harvard University
University of Colorado, Boulder
Center for the Advancement of Value in Musculoskeletal Care, Hospital for Special Surgery
University of Amsterdam
Vrije Universiteit Amsterdam
Erasmus University
University of Copenhagen
University of Toronto
University of Queensland
University of Essex
ETH Zurich
Stuyvesant High School
Massachusetts General Hospital
University of Oxford
23andMe
Barcelona Institute for Global Health
University of Edinburgh
University of Oulu,
University of California San Diego
University of Lübeck
Team Loyalty BV
Universitat Pompeu Fabra
eQTLgen Consortium
International Cannabis Consortium
Psychiatric Genomics Consortium
Social Science Genetic Association Consortium
University of Colorado Boulder
Oulu Business School
University of Konstanz
University of North Carolina at Chapel Hill
University of Bern
Erasmus Medical Center
Karolinska Institutet
Harvard Medical School
SURFsara
McMaster University
University of Oulu
University of Munich
University of Cologne
University College London
University of Chicago
University of Tartu
Stockholm School of Economics
Geisinger Health System
Johannes Gutenberg University
University Health Science
Max Planck Institute for Human Development
University of Minnesota Twin Cities
New York University
University of Southern California

Autoren

Richard Karlsson Linnér
Pietro Biroli
Edward Kong
S Fleur W Meddens
Robee Wedow
Mark Alan Fontana
Maël Lebreton
Abdel Abdellaoui
Anke R Hammerschlag
Michel G Nivard
Aysu Okbay
Cornelius A Rietveld
Pascal N Timshel
Stephen P Tino
Maciej Trzaskowski
Ronald de Vlaming
Christian L Zünd
Yanchun Bao
Laura Buzdugan
Ann H Caplin
Chia-Yen Chen
Peter Eibich
Pierre Fontanillas
Juan R Gonzalez
Peter K Joshi
Ville Karhunen
Aaron Kleinman
Remy Z Levin
Christina M Lill
Gerardus A Meddens
Gerard Muntané
Sandra Sanchez-Roige
Frank J van Rooji
Erdogan Taskesen
Yang Wu
Futao Zhang
23andMe Research Team
eQTLgen Consortium
International Cannabis Consortium
Psychiatric Genomics Consortium
Social Science Genetic Association Consortium
Adam Auton
Jason D Boardman
David W Clark
Andrew Conlin
Conor C Dolan
Urs Fischbacher
Patrick JF Groenen
Kathleen Mullan Harris
Gregor Hasler
Albert Hofman
Mohammad A Ikram
Sonia Jain
Robert Karlsson
Ronald C Kessler
Maarten Kooyman
James MacKillop
Minna Männikkö
Carlos Morcillo-Suarez
Matthew B McQueen
Klaus M Schmidt
Melissa C Smart
Matthias Sutter
A Roy Thurik
Andre G Uitterlinden
Jon White
Harriet de Wit
Jian Yang
Lars Bertram
Dorret Boomsma
Tõnu Esko
Ernst Fehr
David A Hinds
Magnus Johannesson
Meena Kumari
David Laibson
Patrik KE Magnusson
Michelle N Meyer
Arcadi Navarro
Abraham A Palmer
Tune H Pers
Danielle Posthuma
Daniel Schunk
Murray B Stein
Rauli Svento
Henning Tiemeier
Paul RHJ Timmers
Patrick Turley
Robert J Ursano
Gert G Wagner
James F Wilson
Jacob Gratten
James J Lee
David Cesarini
Daniel Benjamin
Philipp Koellinger
Jonathan Beauchamp

Schlüsselwörter

D81
I14
GWAS
genome-wide association studies
risk taking
risk tolerance

Notes

HI,ECI

Artikelnummer

2018-087

Titel

Genome-wide association analyses of risk tolerance and risky behaviors in over one million individuals identify hundreds of loci and shared genetic influences

Datenquelle: RePEc

Beziehungen:

Eigentum von

Public and Behavioral Economics

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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