Obstructive Sleep Apnea Disrupts Glycemic Control in Obese Individuals
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Christopher Seifen
- Johannes Pordzik
- Katharina Ludwig
- Katharina Bahr
- Cornelia Schupp
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000910867400001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/medicina58111602
- eISSN
- 1648-9144
- Externe Identifier
- Clarivate Analytics Document Solution ID: 7S6MC
- PubMed Identifier: 36363559
- ISSN
- 1010-660X
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- MEDICINA-LITHUANIA
- Schlüsselwörter
- obstructive sleep apnea
- apnea-hypopnea index
- body mass index
- obesity and obstructive sleep apnea
- HbA1c
- CRP
- Artikelnummer
- ARTN 1602
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Obstructive Sleep Apnea Disrupts Glycemic Control in Obese Individuals
- Sub types
- Article
- Ausgabe der Zeitschrift
- 58
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>The link between obstructive sleep apnea (OSA) and obesity, and their common comorbidities such as diabetes mellitus (DM) or cardiovascular diseases, is not fully understood. The aim of this study was to investigate the possible association of OSA severity in obese individuals with polysomnography-based sleep parameters, as well as C-reactive protein (CRP) and glycated hemoglobin (HbA1c) serum levels. Polysomnographic recordings and blood samples were retrospectively compared between a group of 23 adult obese individuals with mild OSA (apnea–hypopnea index (AHI) = 7.5 (5.5–12.5)/h, age = 42.57 ± 11.44 years, 16 male, 7 female, body mass index (BMI) = 37.35 ± 3.88 kg/m2) and an age-, sex-, and BMI-matched group of individuals with moderate or severe OSA (AHI 41.5 (25.7–71.8)/h, age = 43.43 ± 11.96 years, 16 male, 7 female, BMI = 37.87 ± 4.74 kg/m2). All respiratory sleep-associated parameters were significantly higher in individuals with moderate and severe OSA compared to those with mild OSA. CRP levels did not differ between the two OSA severity groups. However, serum levels of HbA1c were significantly higher in the moderate/severe OSA group. Therefore, OSA severity may have a significant impact on glycemic control in obese individuals. Additionally, OSA severity did not appear to be further associated with systemic inflammation in obese individuals. Obese individuals may benefit not only from lifestyle modification, but also from OSA screening and treatment, particularly to prevent DM-associated disorders and conditions.</jats:p>
- Autoren
- Christopher Seifen
- Johannes Pordzik
- Katharina Ludwig
- Katharina Bahr
- Cornelia Schupp
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- DOI
- 10.3390/medicina58111602
- eISSN
- 1648-9144
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- Medicina
- Sprache
- en
- Online publication date
- 2022
- Paginierung
- 1602 - 1602
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/medicina58111602
- Datum der Datenerfassung
- 2023
- Titel
- Obstructive Sleep Apnea Disrupts Glycemic Control in Obese Individuals
- Ausgabe der Zeitschrift
- 58
Datenquelle: Crossref
- Abstract
- The link between obstructive sleep apnea (OSA) and obesity, and their common comorbidities such as diabetes mellitus (DM) or cardiovascular diseases, is not fully understood. The aim of this study was to investigate the possible association of OSA severity in obese individuals with polysomnography-based sleep parameters, as well as C-reactive protein (CRP) and glycated hemoglobin (HbA1c) serum levels. Polysomnographic recordings and blood samples were retrospectively compared between a group of 23 adult obese individuals with mild OSA (apnea-hypopnea index (AHI) = 7.5 (5.5-12.5)/h, age = 42.57 ± 11.44 years, 16 male, 7 female, body mass index (BMI) = 37.35 ± 3.88 kg/m²) and an age-, sex-, and BMI-matched group of individuals with moderate or severe OSA (AHI 41.5 (25.7-71.8)/h, age = 43.43 ± 11.96 years, 16 male, 7 female, BMI = 37.87 ± 4.74 kg/m²). All respiratory sleep-associated parameters were significantly higher in individuals with moderate and severe OSA compared to those with mild OSA. CRP levels did not differ between the two OSA severity groups. However, serum levels of HbA1c were significantly higher in the moderate/severe OSA group. Therefore, OSA severity may have a significant impact on glycemic control in obese individuals. Additionally, OSA severity did not appear to be further associated with systemic inflammation in obese individuals. Obese individuals may benefit not only from lifestyle modification, but also from OSA screening and treatment, particularly to prevent DM-associated disorders and conditions.
- Addresses
- Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany.
- Autoren
- Christopher Seifen
- Johannes Pordzik
- Katharina Ludwig
- Katharina Bahr
- Cornelia Schupp
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- DOI
- 10.3390/medicina58111602
- eISSN
- 1648-9144
- Externe Identifier
- PubMed Identifier: 36363559
- PubMed Central ID: PMC9692310
- Open access
- true
- ISSN
- 1010-660X
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- Medicina (Kaunas, Lithuania)
- Schlüsselwörter
- Humans
- Sleep Apnea, Obstructive
- Obesity
- Body Mass Index
- Retrospective Studies
- Adult
- Middle Aged
- Female
- Male
- Glycemic Control
- Glycated Hemoglobin
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2022
- Open access status
- Open Access
- Paginierung
- 1602
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- Obstructive Sleep Apnea Disrupts Glycemic Control in Obese Individuals.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 58
Files
https://www.mdpi.com/1648-9144/58/11/1602/pdf?version=1668496029 https://europepmc.org/articles/PMC9692310?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- The link between obstructive sleep apnea (OSA) and obesity, and their common comorbidities such as diabetes mellitus (DM) or cardiovascular diseases, is not fully understood. The aim of this study was to investigate the possible association of OSA severity in obese individuals with polysomnography-based sleep parameters, as well as C-reactive protein (CRP) and glycated hemoglobin (HbA1c) serum levels. Polysomnographic recordings and blood samples were retrospectively compared between a group of 23 adult obese individuals with mild OSA (apnea-hypopnea index (AHI) = 7.5 (5.5-12.5)/h, age = 42.57 ± 11.44 years, 16 male, 7 female, body mass index (BMI) = 37.35 ± 3.88 kg/m²) and an age-, sex-, and BMI-matched group of individuals with moderate or severe OSA (AHI 41.5 (25.7-71.8)/h, age = 43.43 ± 11.96 years, 16 male, 7 female, BMI = 37.87 ± 4.74 kg/m²). All respiratory sleep-associated parameters were significantly higher in individuals with moderate and severe OSA compared to those with mild OSA. CRP levels did not differ between the two OSA severity groups. However, serum levels of HbA1c were significantly higher in the moderate/severe OSA group. Therefore, OSA severity may have a significant impact on glycemic control in obese individuals. Additionally, OSA severity did not appear to be further associated with systemic inflammation in obese individuals. Obese individuals may benefit not only from lifestyle modification, but also from OSA screening and treatment, particularly to prevent DM-associated disorders and conditions.
- Date of acceptance
- 2022
- Autoren
- Christopher Seifen
- Johannes Pordzik
- Katharina Ludwig
- Katharina Bahr
- Cornelia Schupp
- Christoph Matthias
- Perikles Simon
- Haralampos Gouveris
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36363559
- DOI
- 10.3390/medicina58111602
- eISSN
- 1648-9144
- Externe Identifier
- PubMed Central ID: PMC9692310
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- Medicina (Kaunas)
- Schlüsselwörter
- CRP
- HbA1c
- apnea–hypopnea index
- body mass index
- obesity and obstructive sleep apnea
- obstructive sleep apnea
- Adult
- Male
- Female
- Humans
- Middle Aged
- Glycated Hemoglobin
- Glycemic Control
- Retrospective Studies
- Sleep Apnea, Obstructive
- Obesity
- Body Mass Index
- Sprache
- eng
- Country
- Switzerland
- PII
- medicina58111602
- Datum der Veröffentlichung
- 2022
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Obstructive Sleep Apnea Disrupts Glycemic Control in Obese Individuals.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 58
Datenquelle: PubMed
- Beziehungen:
- Eigentum von