RNA nucleotide methylation: 2021 update

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Yuri Motorin
  • Mark Helm
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000730464200001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/wrna.1691
eISSN
1757-7012
Externe Identifier
  • Clarivate Analytics Document Solution ID: YG3CW
  • PubMed Identifier: 34913259
ISSN
1757-7004
Ausgabe der Veröffentlichung
1
Zeitschrift
WILEY INTERDISCIPLINARY REVIEWS-RNA
Schlüsselwörter
  • epitranscriptomics
  • methylation
  • RNA modification
Artikelnummer
ARTN e1691
Datum der Veröffentlichung
2022
Status
Published
Titel
RNA nucleotide methylation: 2021 update
Sub types
  • Article
Ausgabe der Zeitschrift
13

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:title>Abstract</jats:title><jats:p>Among RNA modifications, transfer of methylgroups from the typical cofactor <jats:italic>S</jats:italic>‐adenosyl‐<jats:sc>l</jats:sc>‐methionine by methyltransferases (MTases) to RNA is by far the most common reaction. Since our last review about a decade ago, the field has witnessed the re‐emergence of mRNA methylation as an important mechanism in gene regulation. Attention has then spread to many other RNA species; all being included into the newly coined concept of the “epitranscriptome.” The focus moved from prokaryotes and single cell eukaryotes as model organisms to higher eukaryotes, in particular to mammals. The perception of the field has dramatically changed over the past decade. A previous lack of phenotypes in knockouts in single cell organisms has been replaced by the apparition of MTases in numerous disease models and clinical investigations. Major driving forces of the field include methylation mapping techniques, as well as the characterization of the various MTases, termed “writers.” The latter term has spilled over from DNA modification in the neighboring epigenetics field, along with the designations “readers,” applied to mediators of biological effects upon specific binding to a methylated RNA. Furthermore “eraser” enzymes effect the newly discovered oxidative removal of methylgroups. A sense of reversibility and dynamics has replaced the older perception of RNA modification as a concrete‐cast, irreversible part of RNA maturation. A related concept concerns incompletely methylated residues, which, through permutation of each site, lead to inhomogeneous populations of numerous modivariants. This review recapitulates the major developments of the past decade outlined above, and attempts a prediction of upcoming trends.</jats:p><jats:p>This article is categorized under:<jats:list list-type="simple"> <jats:list-item><jats:p>RNA Processing &gt; RNA Editing and Modification</jats:p></jats:list-item> </jats:list></jats:p>
Autoren
  • Yuri Motorin
  • Mark Helm
DOI
10.1002/wrna.1691
eISSN
1757-7012
ISSN
1757-7004
Ausgabe der Veröffentlichung
1
Zeitschrift
WIREs RNA
Sprache
en
Online publication date
2021
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/wrna.1691
Datum der Datenerfassung
2023
Titel
<scp>RNA</scp> nucleotide methylation: 2021 update
Ausgabe der Zeitschrift
13

Datenquelle: Crossref

Abstract
Among RNA modifications, transfer of methylgroups from the typical cofactor S-adenosyl-l-methionine by methyltransferases (MTases) to RNA is by far the most common reaction. Since our last review about a decade ago, the field has witnessed the re-emergence of mRNA methylation as an important mechanism in gene regulation. Attention has then spread to many other RNA species; all being included into the newly coined concept of the "epitranscriptome." The focus moved from prokaryotes and single cell eukaryotes as model organisms to higher eukaryotes, in particular to mammals. The perception of the field has dramatically changed over the past decade. A previous lack of phenotypes in knockouts in single cell organisms has been replaced by the apparition of MTases in numerous disease models and clinical investigations. Major driving forces of the field include methylation mapping techniques, as well as the characterization of the various MTases, termed "writers." The latter term has spilled over from DNA modification in the neighboring epigenetics field, along with the designations "readers," applied to mediators of biological effects upon specific binding to a methylated RNA. Furthermore "eraser" enzymes effect the newly discovered oxidative removal of methylgroups. A sense of reversibility and dynamics has replaced the older perception of RNA modification as a concrete-cast, irreversible part of RNA maturation. A related concept concerns incompletely methylated residues, which, through permutation of each site, lead to inhomogeneous populations of numerous modivariants. This review recapitulates the major developments of the past decade outlined above, and attempts a prediction of upcoming trends. This article is categorized under: RNA Processing > RNA Editing and Modification.
Addresses
  • Université de Lorraine, CNRS, INSERM, UMS2008/US40 IBSLor, EpiRNA-Seq Core Facility, Nancy, France.
Autoren
  • Yuri Motorin
  • Mark Helm
DOI
10.1002/wrna.1691
eISSN
1757-7012
Externe Identifier
  • PubMed Identifier: 34913259
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft: TRR 319 TP C03
  • Deutsche Forschungsgemeinschaft: HE3397/17‐1
  • Deutsche Forschungsgemeinschaft: HE3397/18‐2
  • Deutsche Forschungsgemeinschaft: SPP1784
  • Deutsche Forschungsgemeinschaft: TRR 319 TP A05
  • Bundesministerium für Bildung und Forschung: 01EA1903
  • Bundesministerium für Bildung und Forschung: 01ED1804
  • Deutsche Forschungsgemeinschaft: HE3397/21‐1
  • Deutsche Forschungsgemeinschaft: HE3397/13‐2
  • Deutsche Forschungsgemeinschaft: TRR 319 TP C01
  • Deutsche Forschungsgemeinschaft: HE3397/14‐2
  • Agence Nationale de la Recherche:
Open access
false
ISSN
1757-7004
Ausgabe der Veröffentlichung
1
Zeitschrift
Wiley interdisciplinary reviews. RNA
Schlüsselwörter
  • Animals
  • Methyltransferases
  • Nucleotides
  • RNA
  • Epigenesis, Genetic
  • Methylation
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
e1691
Datum der Veröffentlichung
2022
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2021
Titel
RNA nucleotide methylation: 2021 update.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
13

Datenquelle: Europe PubMed Central

Abstract
Among RNA modifications, transfer of methylgroups from the typical cofactor S-adenosyl-l-methionine by methyltransferases (MTases) to RNA is by far the most common reaction. Since our last review about a decade ago, the field has witnessed the re-emergence of mRNA methylation as an important mechanism in gene regulation. Attention has then spread to many other RNA species; all being included into the newly coined concept of the "epitranscriptome." The focus moved from prokaryotes and single cell eukaryotes as model organisms to higher eukaryotes, in particular to mammals. The perception of the field has dramatically changed over the past decade. A previous lack of phenotypes in knockouts in single cell organisms has been replaced by the apparition of MTases in numerous disease models and clinical investigations. Major driving forces of the field include methylation mapping techniques, as well as the characterization of the various MTases, termed "writers." The latter term has spilled over from DNA modification in the neighboring epigenetics field, along with the designations "readers," applied to mediators of biological effects upon specific binding to a methylated RNA. Furthermore "eraser" enzymes effect the newly discovered oxidative removal of methylgroups. A sense of reversibility and dynamics has replaced the older perception of RNA modification as a concrete-cast, irreversible part of RNA maturation. A related concept concerns incompletely methylated residues, which, through permutation of each site, lead to inhomogeneous populations of numerous modivariants. This review recapitulates the major developments of the past decade outlined above, and attempts a prediction of upcoming trends. This article is categorized under: RNA Processing > RNA Editing and Modification.
Date of acceptance
2021
Autoren
  • Yuri Motorin
  • Mark Helm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34913259
DOI
10.1002/wrna.1691
eISSN
1757-7012
Ausgabe der Veröffentlichung
1
Zeitschrift
Wiley Interdiscip Rev RNA
Schlüsselwörter
  • RNA modification
  • epitranscriptomics
  • methylation
  • Animals
  • Epigenesis, Genetic
  • Methylation
  • Methyltransferases
  • Nucleotides
  • RNA
Sprache
eng
Country
United States
Paginierung
e1691
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
RNA nucleotide methylation: 2021 update.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
13

Datenquelle: PubMed

Author's licence
CC-BY
Autoren
  • Yuri Motorin
  • Mark Helm
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1002/wrna.1691
File(s) embargoed
false
Open access
true
ISSN
1757-7012
Ausgabe der Veröffentlichung
1
Zeitschrift
Wiley interdisciplinary reviews : RNA
Schlüsselwörter
  • 540 Chemie
  • 540 Chemistry and allied sciences
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
e1691
Datum der Veröffentlichung
2022
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/8050
Herausgeber
Wiley-Blackwell
Datum der Datenerfassung
2022
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Zugang
Public
Titel
RNA nucleotide methylation: 2021 update
Ausgabe der Zeitschrift
13

Files

rna_nucleotide_methylation__2-20221014165041422.pdf

Datenquelle: OPENSCIENCE.UB

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