The Development of Vaccines from Synthetic Tumor-Associated Mucin Glycopeptides and their Glycosylation-Dependent Immune Response

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Natascha Stergiou
  • Moritz Urschbach
  • Adele Gabba
  • Edgar Schmitt
  • Horst Kunz
  • Pol Besenius
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000721424500001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/tcr.202100182
eISSN
1528-0691
Externe Identifier
  • Clarivate Analytics Document Solution ID: XC9KR
  • PubMed Identifier: 34812564
ISSN
1527-8999
Ausgabe der Veröffentlichung
11
Zeitschrift
CHEMICAL RECORD
Schlüsselwörter
  • Immunotherapy
  • anti-tumor vaccines
  • glycoconjugate
  • subunit vaccines
  • glycopeptide antigens
Paginierung
3313 - 3331
Datum der Veröffentlichung
2021
Status
Published
Titel
The Development of Vaccines from Synthetic Tumor-Associated Mucin Glycopeptides and their Glycosylation-Dependent Immune Response
Sub types
  • Review
Ausgabe der Zeitschrift
21

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:title>Abstract</jats:title><jats:p>Tumor‐associated carbohydrate antigens are overexpressed as altered‐self in most common epithelial cancers. Their glycosylation patterns differ from those of healthy cells, functioning as an ID for cancer cells. Scientists have been developing anti‐cancer vaccines based on mucin glycopeptides, yet the interplay of delivery system, adjuvant and tumor associated MUC epitopes in the induced immune response is not well understood. The current state of the art suggests that the identity, abundancy and location of the glycans on the MUC backbone are all key parameters in the cellular and humoral response. This review shares lessons learned by us in over two decades of research in glycopeptide vaccines. By bridging synthetic chemistry and immunology, we discuss efforts in designing synthetic MUC1/4/16 vaccines and focus on the role of glycosylation patterns. We provide a brief introduction into the mechanisms of the immune system and aim to promote the development of cancer subunit vaccines.</jats:p>
Autoren
  • Natascha Stergiou
  • Moritz Urschbach
  • Adele Gabba
  • Edgar Schmitt
  • Horst Kunz
  • Pol Besenius
DOI
10.1002/tcr.202100182
eISSN
1528-0691
ISSN
1527-8999
Ausgabe der Veröffentlichung
11
Zeitschrift
The Chemical Record
Sprache
en
Online publication date
2021
Paginierung
3313 - 3331
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/tcr.202100182
Datum der Datenerfassung
2023
Titel
The Development of Vaccines from Synthetic Tumor‐Associated Mucin Glycopeptides and their Glycosylation‐Dependent Immune Response
Ausgabe der Zeitschrift
21

Datenquelle: Crossref

Abstract
Tumor-associated carbohydrate antigens are overexpressed as altered-self in most common epithelial cancers. Their glycosylation patterns differ from those of healthy cells, functioning as an ID for cancer cells. Scientists have been developing anti-cancer vaccines based on mucin glycopeptides, yet the interplay of delivery system, adjuvant and tumor associated MUC epitopes in the induced immune response is not well understood. The current state of the art suggests that the identity, abundancy and location of the glycans on the MUC backbone are all key parameters in the cellular and humoral response. This review shares lessons learned by us in over two decades of research in glycopeptide vaccines. By bridging synthetic chemistry and immunology, we discuss efforts in designing synthetic MUC1/4/16 vaccines and focus on the role of glycosylation patterns. We provide a brief introduction into the mechanisms of the immune system and aim to promote the development of cancer subunit vaccines.
Addresses
  • Radionuclide Center, Radiology and Nuclear medicine Amsterdam UMC, VU University, De Boelelaan 1085c, 1081 HV, Amsterdam, the Netherlands.
Autoren
  • Natascha Stergiou
  • Moritz Urschbach
  • Adele Gabba
  • Edgar Schmitt
  • Horst Kunz
  • Pol Besenius
DOI
10.1002/tcr.202100182
eISSN
1528-0691
Externe Identifier
  • PubMed Identifier: 34812564
Funding acknowledgements
  • European Research Council:
  • Deutsche Forschungsgemeinschaft (DFG): CRC 1066
  • European Union's Horizon 2020 research and innovation programme: ERC CoG SUPRAVACC - 819856
Open access
false
ISSN
1527-8999
Ausgabe der Veröffentlichung
11
Zeitschrift
Chemical record (New York, N.Y.)
Schlüsselwörter
  • Humans
  • Neoplasms
  • Glycopeptides
  • Mucins
  • Vaccines, Synthetic
  • Cancer Vaccines
  • Immunity
  • Glycosylation
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
3313 - 3331
Datum der Veröffentlichung
2021
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2021
Titel
The Development of Vaccines from Synthetic Tumor-Associated Mucin Glycopeptides and their Glycosylation-Dependent Immune Response.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
21

Datenquelle: Europe PubMed Central

Abstract
Tumor-associated carbohydrate antigens are overexpressed as altered-self in most common epithelial cancers. Their glycosylation patterns differ from those of healthy cells, functioning as an ID for cancer cells. Scientists have been developing anti-cancer vaccines based on mucin glycopeptides, yet the interplay of delivery system, adjuvant and tumor associated MUC epitopes in the induced immune response is not well understood. The current state of the art suggests that the identity, abundancy and location of the glycans on the MUC backbone are all key parameters in the cellular and humoral response. This review shares lessons learned by us in over two decades of research in glycopeptide vaccines. By bridging synthetic chemistry and immunology, we discuss efforts in designing synthetic MUC1/4/16 vaccines and focus on the role of glycosylation patterns. We provide a brief introduction into the mechanisms of the immune system and aim to promote the development of cancer subunit vaccines.
Date of acceptance
2021
Autoren
  • Natascha Stergiou
  • Moritz Urschbach
  • Adele Gabba
  • Edgar Schmitt
  • Horst Kunz
  • Pol Besenius
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34812564
DOI
10.1002/tcr.202100182
eISSN
1528-0691
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft (DFG): CRC 1066
  • European Research Council (ERC):
  • European Union's Horizon 2020 research and innovation programme: ERC CoG SUPRAVACC - 819856
Ausgabe der Veröffentlichung
11
Zeitschrift
Chem Rec
Schlüsselwörter
  • Immunotherapy
  • anti-tumor vaccines
  • glycoconjugate
  • glycopeptide antigens
  • subunit vaccines
  • Cancer Vaccines
  • Glycopeptides
  • Glycosylation
  • Humans
  • Immunity
  • Mucins
  • Neoplasms
  • Vaccines, Synthetic
Sprache
eng
Country
United States
Paginierung
3313 - 3331
Datum der Veröffentlichung
2021
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
The Development of Vaccines from Synthetic Tumor-Associated Mucin Glycopeptides and their Glycosylation-Dependent Immune Response.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
21

Datenquelle: PubMed

Author's licence
CC-BY
Autoren
  • Natascha Stergiou
  • Moritz Urschbach
  • Adele Gabba
  • Edgar Schmitt
  • Horst Kunz
  • Pol Besenius
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1002/tcr.202100182
File(s) embargoed
false
Open access
true
ISSN
1528-0691
Ausgabe der Veröffentlichung
11
Zeitschrift
The chemical record
Schlüsselwörter
  • 540 Chemie
  • 540 Chemistry and allied sciences
Sprache
eng
Open access status
Open Access
Paginierung
3313 - 3331
Datum der Veröffentlichung
2021
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/8040
Herausgeber
Wiley
Datum der Datenerfassung
2022
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Zugang
Public
Titel
The development of vaccines from synthetic tumor-associated mucin glycopeptides and their glycosylation-dependent immune response
Ausgabe der Zeitschrift
21

Files

the_development_of_vaccines_f-20221014155758630.pdf

Datenquelle: OPENSCIENCE.UB

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