Membranous expression and prognostic implications of epidermal growth factor receptor protein in human renal cell cancer

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • AS Merseburger
  • J Hennenlotter
  • P Simon
  • S Kruck
  • E Koch
  • M Horstmann
  • U Kuehs
  • R Küfer
  • A Stenzl
  • MA Kuczyk
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000230097400009&DestLinkType=FullRecord&DestApp=WOS_CPL
eISSN
1791-7530
Externe Identifier
  • Clarivate Analytics Document Solution ID: 939UH
  • PubMed Identifier: 16158924
ISSN
0250-7005
Ausgabe der Veröffentlichung
3B
Zeitschrift
ANTICANCER RESEARCH
Schlüsselwörter
  • renal cell cancer
  • EGFR
  • clinical prognosis
  • tissue microarray
  • survival
Paginierung
1901 - 1907
Datum der Veröffentlichung
2005
Status
Published
Titel
Membranous expression and prognostic implications of epidermal growth factor receptor protein in human renal cell cancer
Sub types
  • Article
Ausgabe der Zeitschrift
25

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<h4>Background</h4>It has been indicated that altered expression of the epidermal growth factor receptor (EGFR) promotes the invasive and metastatic potential of a variety of human malignancies. Therefore, the aim of the present study was to determine EGFR expression in clear cell renal cell carcinomas (RCC) to evaluate its prognostic relevance for the clinical course of the disease.<h4>Materials and methods</h4>EGFR protein expression, detected by immunohistochemistry and tissue microarray analysis (TMA), was investigated in a cohort of 149 randomly selected patients subjected to tumor nephrectomy for RCC.<h4>Results</h4>The tumor cells preferably exhibited a homogeneous membrane-bound reactivity for EGFR; EGFR overexpression was detected in 70 (47%) of the primary tumor specimens, but in only 12 (9%) of the benign tissue samples (p<0.0001; Fisher's t-test). Tumor-associated EGFR staining was stratified into three groups: I: low staining score (n=75, 50%); II: intense expression (n=56, 38%); and III: strong overexpression (n = 18, 12%). Strong reactivity for EGFR was identified as predicting the patients' survival both during uni- and multivariate analysis (p=0.03). Interestingly, the overall survival of the intense expression group surpassed even the low expression group (p=0.023).<h4>Conclusion</h4>The observation that primary RCC specimens exhibit EGFR at higher levels when compared with benign renal parenchyma indicates its role in tumor development and progression. The availability of more refined prognostic factors would assist decision making in terms of the value of more aggressive treatment options for prognostically defined subgroups of patients. Additionally, if overexpression of EGFR identifies RCC with a more aggressive biological behavior, the latter receptor might serve as a novel target for a more effective therapeutical approach to RCC.
Addresses
  • Department of Urology, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.
Autoren
  • Axel S Merseburger
  • Jörg Hennenlotter
  • Perikles Simon
  • Stephan Kruck
  • Eva Koch
  • Marcus Horstmann
  • Ursula Kuehs
  • Rainer Küfer
  • Arnulf Stenzl
  • Markus A Kuczyk
eISSN
1791-7530
Externe Identifier
  • PubMed Identifier: 16158924
Open access
false
ISSN
0250-7005
Ausgabe der Veröffentlichung
3B
Zeitschrift
Anticancer research
Schlüsselwörter
  • Cell Membrane
  • Humans
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Neoplasm Staging
  • Prognosis
  • Immunohistochemistry
  • Survival Rate
  • Proportional Hazards Models
  • Cohort Studies
  • Middle Aged
  • Female
  • Male
  • ErbB Receptors
Sprache
eng
Medium
Print
Paginierung
1901 - 1907
Datum der Veröffentlichung
2005
Status
Published
Datum der Datenerfassung
2005
Titel
Membranous expression and prognostic implications of epidermal growth factor receptor protein in human renal cell cancer.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
25

Datenquelle: Europe PubMed Central

Abstract
BACKGROUND: It has been indicated that altered expression of the epidermal growth factor receptor (EGFR) promotes the invasive and metastatic potential of a variety of human malignancies. Therefore, the aim of the present study was to determine EGFR expression in clear cell renal cell carcinomas (RCC) to evaluate its prognostic relevance for the clinical course of the disease. MATERIALS AND METHODS: EGFR protein expression, detected by immunohistochemistry and tissue microarray analysis (TMA), was investigated in a cohort of 149 randomly selected patients subjected to tumor nephrectomy for RCC. RESULTS: The tumor cells preferably exhibited a homogeneous membrane-bound reactivity for EGFR; EGFR overexpression was detected in 70 (47%) of the primary tumor specimens, but in only 12 (9%) of the benign tissue samples (p<0.0001; Fisher's t-test). Tumor-associated EGFR staining was stratified into three groups: I: low staining score (n=75, 50%); II: intense expression (n=56, 38%); and III: strong overexpression (n = 18, 12%). Strong reactivity for EGFR was identified as predicting the patients' survival both during uni- and multivariate analysis (p=0.03). Interestingly, the overall survival of the intense expression group surpassed even the low expression group (p=0.023). CONCLUSION: The observation that primary RCC specimens exhibit EGFR at higher levels when compared with benign renal parenchyma indicates its role in tumor development and progression. The availability of more refined prognostic factors would assist decision making in terms of the value of more aggressive treatment options for prognostically defined subgroups of patients. Additionally, if overexpression of EGFR identifies RCC with a more aggressive biological behavior, the latter receptor might serve as a novel target for a more effective therapeutical approach to RCC.
Autoren
  • Axel S Merseburger
  • Jörg Hennenlotter
  • Perikles Simon
  • Stephan Kruck
  • Eva Koch
  • Marcus Horstmann
  • Ursula Kuehs
  • Rainer Küfer
  • Arnulf Stenzl
  • Markus A Kuczyk
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/16158924
ISSN
0250-7005
Ausgabe der Veröffentlichung
3B
Zeitschrift
Anticancer Res
Schlüsselwörter
  • Carcinoma, Renal Cell
  • Cell Membrane
  • Cohort Studies
  • ErbB Receptors
  • Female
  • Humans
  • Immunohistochemistry
  • Kidney Neoplasms
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • Proportional Hazards Models
  • Survival Rate
Sprache
eng
Country
Greece
Paginierung
1901 - 1907
Datum der Veröffentlichung
2005
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2005
Titel
Membranous expression and prognostic implications of epidermal growth factor receptor protein in human renal cell cancer.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
25

Datenquelle: PubMed

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