Regulation of immediate early gene expression by exercise: Short cuts for the adaptation of immune function

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Perikles Simon
  • Elvira Fehrenbach
  • Andreas M Niess
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000242978800008&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: 118YG
  • PubMed Identifier: 17201076
ISSN
1077-5552
Zeitschrift
EXERCISE IMMUNOLOGY REVIEW
Schlüsselwörter
  • immediate early genes
  • posttranscriptional regulation
  • cytokines
  • ncRNA
  • cisNAT
Paginierung
112 - 131
Datum der Veröffentlichung
2006
Status
Published
Titel
Regulation of immediate early gene expression by exercise: Short cuts for the adaptation of immune function
Sub types
  • Review
Ausgabe der Zeitschrift
12

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
Onset of physical activity induces a wide variety of rapid biophysical and biochemical responses that act on cells and lead to a wide range of phenotypic adaptations. Here we elucidate the role of immediate early gene (IEG) expression as a first line of transcriptional response that mediates protein neosynthesis and leads to adaptation of immune function. New posttranscriptional mechanisms have been described that speed up transcriptional responses. These include RNA-RNA interactions such as those exploited by miRNAs and stimulus-dependent cytoplasmic polyadenylation. We describe these shortcuts that modulate expression and discuss the challenges of accurately measuring them using various transcriptomic screening and quantification approaches. Although there is high complexity of the upstream as well as the downstream pathways that lead to IEG expression, IEG expression itself may only show a limited number of response patterns. Focusing transcriptomic approaches in exercise immunology at the IEG-level may facilitate the discovery of exercise-specific transcriptional signatures.
Addresses
  • Department of Sports Medicine, Medical Clinic, University of Tübingen, Germany. perikles@uni-tuebingen.de
Autoren
  • Perikles Simon
  • Elvira Fehrenbach
  • Andreas M Niess
eISSN
2959-9555
Externe Identifier
  • PubMed Identifier: 17201076
Open access
false
ISSN
1077-5552
Zeitschrift
Exercise immunology review
Schlüsselwörter
  • Leukocytes
  • Humans
  • Immediate-Early Proteins
  • Exercise
  • Adaptation, Physiological
  • Immunity
  • Transcription, Genetic
  • Gene Expression Regulation
  • Genes, Immediate-Early
  • Models, Biological
Sprache
eng
Medium
Print
Paginierung
112 - 131
Datum der Veröffentlichung
2006
Status
Published
Datum der Datenerfassung
2007
Titel
Regulation of immediate early gene expression by exercise: short cuts for the adaptation of immune function.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
12

Datenquelle: Europe PubMed Central

Abstract
Onset of physical activity induces a wide variety of rapid biophysical and biochemical responses that act on cells and lead to a wide range of phenotypic adaptations. Here we elucidate the role of immediate early gene (IEG) expression as a first line of transcriptional response that mediates protein neosynthesis and leads to adaptation of immune function. New posttranscriptional mechanisms have been described that speed up transcriptional responses. These include RNA-RNA interactions such as those exploited by miRNAs and stimulus-dependent cytoplasmic polyadenylation. We describe these shortcuts that modulate expression and discuss the challenges of accurately measuring them using various transcriptomic screening and quantification approaches. Although there is high complexity of the upstream as well as the downstream pathways that lead to IEG expression, IEG expression itself may only show a limited number of response patterns. Focusing transcriptomic approaches in exercise immunology at the IEG-level may facilitate the discovery of exercise-specific transcriptional signatures.
Autoren
  • Perikles Simon
  • Elvira Fehrenbach
  • Andreas M Niess
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/17201076
ISSN
1077-5552
Zeitschrift
Exerc Immunol Rev
Schlüsselwörter
  • Adaptation, Physiological
  • Exercise
  • Gene Expression Regulation
  • Genes, Immediate-Early
  • Humans
  • Immediate-Early Proteins
  • Immunity
  • Leukocytes
  • Models, Biological
  • Transcription, Genetic
Sprache
eng
Country
Germany
Paginierung
112 - 131
Datum der Veröffentlichung
2006
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2007
Titel
Regulation of immediate early gene expression by exercise: short cuts for the adaptation of immune function.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
12

Datenquelle: PubMed

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