Gradual discontinuation of hormone therapy does not prevent the reappearance of climacteric symptoms: a randomized prospective study

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Ronit Haimov-Kochman
  • Edyah Barak-Glantz
  • Revital Arbel
  • Miriam Leefsma
  • Amnon Brzezinski
  • Ariel Milwidsky
  • Drorith Hochner-Celnikier
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000238116100007&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1097/01.gme.0000186663.36211.c0
eISSN
1530-0374
Externe Identifier
  • Clarivate Analytics Document Solution ID: 050VD
  • PubMed Identifier: 16735933
ISSN
1072-3714
Ausgabe der Veröffentlichung
3
Zeitschrift
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
Schlüsselwörter
  • discontinuation
  • Greene scale
  • hormone therapy
  • menopause
  • vasomotor symptoms
Paginierung
370 - 376
Datum der Veröffentlichung
2006
Status
Published
Titel
Gradual discontinuation of hormone therapy does not prevent the reappearance of climacteric symptoms: a randomized prospective study
Sub types
  • Article
Ausgabe der Zeitschrift
13

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • &NA;
DOI
10.1097/01.gme.0000186663.36211.c0
ISSN
1559-047X
Ausgabe der Veröffentlichung
5
Zeitschrift
Journal of Burn Care & Research
Sprache
en
Paginierung
774 - 774
Datum der Veröffentlichung
2007
Status
Published
Herausgeber
Oxford University Press (OUP)
Herausgeber URL
http://dx.doi.org/10.1097/01.gme.0000186663.36211.c0
Datum der Datenerfassung
2018
Titel
ERRATUM
Ausgabe der Zeitschrift
28

Datenquelle: Crossref

Abstract
<h4>Objective</h4>To investigate the recurrence and severity of climacteric symptoms after two methods of discontinuation of prolonged hormone therapy.<h4>Design</h4>Postmenopausal women treated with hormone therapy for more than 3 years and opting to discontinue therapy were randomly assigned to two treatment groups. Hormone therapy was discontinued either abruptly (group 1) or gradually (group 2). Symptoms in both groups were monitored with the Greene climacteric scale at 1, 3, 6, 9, and 12 months.<h4>Results</h4>Ninety-one women aged 48 to 73 years (mean age 56.8 +/- 4.2 years) participated in the study. The mean therapy duration was 8.8 +/- 3.8 years. No differences were noted between the two groups regarding age at menopause, body mass index, reasons to start therapy, hormone therapy duration, type of regimen, and reasons cited for hormone treatment discontinuation. After cessation of therapy, a similar percentage of patients in each group resumed hormone therapy. Climacteric syndromes, specifically vasomotor dysfunction, were more severe in group 1 than in group 2 during the first 3 months after hormone therapy withdrawal. However, by 6 months vasomotor symptoms were worse in group 2. By 9 to 12 months, no difference was noted between groups. No differences were observed in the percentage of weight gain, vaginal bleeding, and atrophy after discontinuation of therapy by either method.<h4>Conclusions</h4>Our specific regimen of gradual discontinuation of hormone therapy merely postponed, and neither prevented nor minimized, the reappearance of vasomotor symptoms, mood deterioration, and sexual dysfunction, and the resulting discomfort.
Addresses
  • Department of Obstetrics and Gynecology, Hadassah Medical Center, Hebrew University Hospital, Mount Scopus, Jerusalem, Israel. kochman@hadassah.org.il
Autoren
  • Ronit Haimov-Kochman
  • Edyah Barak-Glantz
  • Revital Arbel
  • Miriam Leefsma
  • Amnon Brzezinski
  • Ariel Milwidsky
  • Drorith Hochner-Celnikier
DOI
10.1097/01.gme.0000186663.36211.c0
eISSN
1530-0374
Externe Identifier
  • PubMed Identifier: 16735933
Open access
false
ISSN
1072-3714
Ausgabe der Veröffentlichung
3
Zeitschrift
Menopause (New York, N.Y.)
Schlüsselwörter
  • Humans
  • Recurrence
  • Hot Flashes
  • Estrogens
  • Progestins
  • Treatment Outcome
  • Estrogen Replacement Therapy
  • Drug Administration Schedule
  • Severity of Illness Index
  • Prospective Studies
  • Treatment Refusal
  • Menopause
  • Aged
  • Middle Aged
  • Female
Sprache
eng
Medium
Print
Paginierung
370 - 376
Datum der Veröffentlichung
2006
Status
Published
Datum der Datenerfassung
2006
Titel
Gradual discontinuation of hormone therapy does not prevent the reappearance of climacteric symptoms: a randomized prospective study.
Sub types
  • Randomized Controlled Trial
  • Journal Article
Ausgabe der Zeitschrift
13

Datenquelle: Europe PubMed Central

Abstract
OBJECTIVE: To investigate the recurrence and severity of climacteric symptoms after two methods of discontinuation of prolonged hormone therapy. DESIGN: Postmenopausal women treated with hormone therapy for more than 3 years and opting to discontinue therapy were randomly assigned to two treatment groups. Hormone therapy was discontinued either abruptly (group 1) or gradually (group 2). Symptoms in both groups were monitored with the Greene climacteric scale at 1, 3, 6, 9, and 12 months. RESULTS: Ninety-one women aged 48 to 73 years (mean age 56.8 +/- 4.2 years) participated in the study. The mean therapy duration was 8.8 +/- 3.8 years. No differences were noted between the two groups regarding age at menopause, body mass index, reasons to start therapy, hormone therapy duration, type of regimen, and reasons cited for hormone treatment discontinuation. After cessation of therapy, a similar percentage of patients in each group resumed hormone therapy. Climacteric syndromes, specifically vasomotor dysfunction, were more severe in group 1 than in group 2 during the first 3 months after hormone therapy withdrawal. However, by 6 months vasomotor symptoms were worse in group 2. By 9 to 12 months, no difference was noted between groups. No differences were observed in the percentage of weight gain, vaginal bleeding, and atrophy after discontinuation of therapy by either method. CONCLUSIONS: Our specific regimen of gradual discontinuation of hormone therapy merely postponed, and neither prevented nor minimized, the reappearance of vasomotor symptoms, mood deterioration, and sexual dysfunction, and the resulting discomfort.
Autoren
  • Ronit Haimov-Kochman
  • Edyah Barak-Glantz
  • Revital Arbel
  • Miriam Leefsma
  • Amnon Brzezinski
  • Ariel Milwidsky
  • Drorith Hochner-Celnikier
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/16735933
DOI
10.1097/01.gme.0000186663.36211.c0
ISSN
1072-3714
Ausgabe der Veröffentlichung
3
Zeitschrift
Menopause
Schlüsselwörter
  • Aged
  • Drug Administration Schedule
  • Estrogen Replacement Therapy
  • Estrogens
  • Female
  • Hot Flashes
  • Humans
  • Menopause
  • Middle Aged
  • Progestins
  • Prospective Studies
  • Recurrence
  • Severity of Illness Index
  • Treatment Outcome
  • Treatment Refusal
Sprache
eng
Country
United States
Paginierung
370 - 376
Datum der Veröffentlichung
2006
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2006
Titel
Gradual discontinuation of hormone therapy does not prevent the reappearance of climacteric symptoms: a randomized prospective study.
Sub types
  • Journal Article
  • Randomized Controlled Trial
Ausgabe der Zeitschrift
13

Datenquelle: PubMed

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